{ "categories": [ { "name": "common", "description": "Common drugs are those which are well known and widely used among the drug community. This doesn't necessarily mean they are safe, but it usually comes with a longer relative history of use in humans with which to establish a safety profile.", "color": 4278876927 }, { "name": "psychedelic", "description": "Psychedelics are drugs which alter the perception, causing a number of mental effects which manifest in many forms including altered states of consciousness, visual or tactile effects.", "url": "https://psychonautwiki.org/wiki/Psychedelics", "color": 4287564543 }, { "name": "stimulant", "description": "Stimulants excite the nervous system and increase physiological function.", "url": "https://psychonautwiki.org/wiki/Stimulants", "color": 4278246860 }, { "name": "entactogen", "description": "Entactogens (also known as empathogens) are a class of psychoactive substances that produce distinctive emotional and social effects similar to those of MDMA.", "url": "https://psychonautwiki.org/wiki/Entactogens", "color": 4294904442 }, { "name": "depressant", "description": "Depressants are drugs which reduce arousal and stimulation in the user, characterised by a depressing of mental and physical functions.", "url": "https://psychonautwiki.org/wiki/Depressant", "color": 4294606340 }, { "name": "opioid", "description": "Opioids are pain-killing depressants which may also cause euphoria.", "url": "https://psychonautwiki.org/wiki/Opioids", "color": 4294955889 }, { "name": "habit-forming", "description": "These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.", "color": 4291698538 }, { "name": "research-chemical", "description": "Research chemicals are drugs with relatively little history of human use, and thus particular care should be taken if choosing to ingest them.", "url": "https://psychonautwiki.org/wiki/Research_chemicals", "color": 4286350333 }, { "name": "tentative", "description": "Tentative means that there is not much reliable information about it. This is often because the drug is very new. Information listed under these drugs should not be entirely trusted.", "color": 4287054400 }, { "name": "dissociative", "description": "Dissociatives are mostly NMDA receptor antagonists, these substances are hallucinogenic but different than psychedelics. As per the name, these substances create a distance between the user and reality.", "url": "https://psychonautwiki.org/wiki/Dissociatives", "color": 4294928359 }, { "name": "benzodiazepine", "description": "Benzodiazepines are generally hypnotic or anxiolytic depressant drugs.", "url": "https://psychonautwiki.org/wiki/Benzodiazepines", "color": 4291603072 }, { "name": "cannabinoid", "description": "A cannabinoid is one of a class of diverse chemical compounds that act on cannabinoid receptors on cells that alter neurotransmitter functioning in the brain.", "url": "https://psychonautwiki.org/wiki/Cannabinoid", "color": 4282175310 }, { "name": "nootropic", "description": "Nootropics (also referred to as smart drugs, neuro enhancers, and cognitive enhancers) are substances that purportedly improve cognitive functions such as memory, motivation, attention, and concentration, in healthy individuals.", "url": "https://psychonautwiki.org/wiki/Nootropic", "color": 4282309616 }, { "name": "deliriant", "description": "Deliriants are considered to be true hallucinogens, because the visuals they produce are hard or impossible to tell apart from reality; they are also known for negative physical effects.", "url": "https://psychonautwiki.org/wiki/Deliriant", "color": 4278452378 }, { "name": "barbiturate", "description": "Barbiturates (also known as barbs and barbies) are a class of psychoactive substances that act as depressants of the central nervous system. They produce a variety of sedative-hypnotic effects including sedation, anxiety suppression, muscle relaxation, and seizure suppression when administered.", "url": "https://psychonautwiki.org/wiki/Barbiturates", "color": 4279550862 }, { "name": "eugeroic", "description": "Eugeroics, also known as wakefulness-promoting agents and wakefulness-promoting drugs, are a class of psychoactive substances that promote wakefulness and alertness. The best-known member of this class is modafinil.", "url": "https://psychonautwiki.org/wiki/Eugeroics", "color": 4283267071 }, { "name": "hallucinogen", "description": "Hallucinogens are a class of psychoactive substances that produce powerful alterations in perception, mood, and various cognitive processes. Hallucinogens can be classified into psychedelics, dissociatives and deliriants", "url": "https://psychonautwiki.org/wiki/Hallucinogens", "color": 4294554120 }, { "name": "oneirogen", "description": "Oneirogen describes a wide array of psychoactive plants and chemicals ranging from normal dream enhancers to intense dissociative or deliriant drugs.", "url": "https://psychonautwiki.org/wiki/Oneirogen", "color": 4290969561 }, { "name": "antipsychotic", "description": "Antipsychotics (also known as neuroleptics or major tranquilizers) are a class of psychiatric medication primarily used to manage psychosis (including delusions, hallucinations, or disordered thought), particularly in schizophrenia and bipolar disorder.", "url": "https://psychonautwiki.org/wiki/Antipsychotic", "color": 4293455940 }, { "name": "antidepressant", "description": "Antidepressants are a class of psychoactive substances that are prescribed to treat psychiatric disorders, most commonly major depressive disorder and some forms of anxiety disorders.", "url": "https://psychonautwiki.org/wiki/Antidepressants", "color": 4294954702 }, { "name": "hypnotic", "description": "Hypnotics, or soporifics, are a class of drugs which promote and induce sleep. They are the opposite of eugeroics which promote wakefulness. They are commonly distributed in the form of pharmaceutical drugs prescribed to treat insomnia.", "url": "https://psychonautwiki.org/wiki/Hypnotic", "color": 4293455940 } ], "substances": [ { "name": "1,3-dimethylbutylamine", "commonNames": [], "url": "https://psychonautwiki.org/wiki/1,3-dimethylbutylamine", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant" ], "roas": [ { "name": "oral", "dose": { "units": "mg" } } ] }, { "name": "1,4-Butanediol", "commonNames": [ "1,4-Butanediol", "1,4-B", "BD", "BDO", "One Comma Four", "One Four Bee", "Butylene Glycol", "One Four B-D-O" ], "url": "https://psychonautwiki.org/wiki/1,4-Butanediol", "isApproved": true, "tolerance": { "full": "within several weeks of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [], "addictionPotential": "moderately physically and psychologically addictive", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "depressant", "habit-forming" ], "summary": "1,4-BD is a clear liquid with intoxicating effects. It is a pro-drug for GHB, and has similar though reportedly inferior effects. It also carries the potential for more health risks than GHB, such as liver damage and neurotoxicity.", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mL", "lightMin": 0.5, "commonMin": 1, "strongMin": 2.5, "heavyMin": 4 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1.5, "max": 2, "units": "hours" }, "total": { "min": 3, "max": 5, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "1cP-AL-LAD", "commonNames": [ "1cP-AL-LAD" ], "url": "https://psychonautwiki.org/wiki/1cP-AL-LAD", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown", "extremely low toxicity" ], "categories": [ "psychedelic" ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 20, "commonMin": 100, "strongMin": 225, "heavyMin": 350 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2.5, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 7, "max": 10, "units": "hours" }, "afterglow": { "min": 2, "max": 18, "units": "hours" } } } ] }, { "name": "1cP-LSD", "commonNames": [ "1cP-LSD" ], "url": "https://psychonautwiki.org/wiki/1cP-LSD", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "non-addictive with a low abuse potential", "toxicities": [], "categories": [ "psychedelic" ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 15, "commonMin": 75, "strongMin": 150, "heavyMin": 300 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 45, "max": 120, "units": "minutes" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 3, "max": 5, "units": "hours" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "1cP-MiPLA", "commonNames": [ "1cP-MiPLA" ], "url": "https://psychonautwiki.org/wiki/1cP-MiPLA", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown", "extremely low toxicity" ], "categories": [ "psychedelic" ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 50, "commonMin": 150, "strongMin": 200, "heavyMin": 300 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "1P-ETH-LAD", "commonNames": [ "1P-ETH-LAD", "1-Propionyl-6-ethyl-6-nor-lysergic acid diethyamide" ], "url": "https://psychonautwiki.org/wiki/1P-ETH-LAD", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "tentative", "research-chemical" ], "summary": "A new psychedelic lysergamide which is suspected to be a prodrug of ETH-LAD, which could explain why the doses are very similar. Or it could be active on its own. Scientific studies would need to be written to understand, yet there are none.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 25, "commonMin": 60, "strongMin": 100, "heavyMin": 200 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 6, "max": 12, "units": "hours" } } } ] }, { "name": "1P-LSD", "commonNames": [ "1P-LSD" ], "url": "https://psychonautwiki.org/wiki/1P-LSD", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "non-addictive with a low abuse potential", "toxicities": [ "extremely low toxicity relative to dose" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "An LSD analogue which appears to be slightly more potent with a shorter duration. Its effects are reported to be extremely similar to LSD, and thus far seems to be similarly safe. Released in late 2014, It has quickly become a highly popular research chemical due to its implicit legality, similarity to LSD and wide availability on the Internet.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 15, "commonMin": 75, "strongMin": 150, "heavyMin": 300 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 45, "max": 120, "units": "minutes" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 3, "max": 5, "units": "hours" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "1V-LSD", "commonNames": [ "1V-LSD" ], "url": "https://psychonautwiki.org/wiki/1V-LSD", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "non-addictive with a low abuse potential", "toxicities": [ "extremely low toxicity relative to dose" ], "categories": [ "psychedelic" ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 15, "commonMin": 75, "strongMin": 150, "heavyMin": 300 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 45, "max": 120, "units": "minutes" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 3, "max": 5, "units": "hours" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "2-Aminoindane", "commonNames": [ "2-AI" ], "url": "https://psychonautwiki.org/wiki/2-Aminoindane", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "Stimulants", "MDMA", "Cocaine" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 10, "strongMin": 20, "heavyMin": 40 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "total": { "min": 1, "max": 2, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "2-FA", "commonNames": [ "2-FA" ], "url": "https://psychonautwiki.org/wiki/2-FA", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 10 days", "halfToleranceInHours": 120, "zeroToleranceInHours": 132 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "research-chemical", "habit-forming" ], "summary": "Stimulant drug of the amphetamine family. Reported as having effects similar to those of Dextroamphetamine, but with a milder euphoria and a comparatively smoother comedown. Has a shorter duration and less empathogenic effect-profile as compared with 4-FA. Thought to produce less neurotoxic metabolites compared to amphetamine.", "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 30, "strongMin": 50, "heavyMin": 60 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "2-FEA", "commonNames": [ "2-FEA" ], "url": "https://psychonautwiki.org/wiki/2-FEA", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "tentative", "research-chemical" ], "summary": "Stimulant closely related to 2-FMA. Presumably slightly less potent than the prior. Toxicology and the likes are pretty much completely unknown. Tread with caution.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "Stimulants", "MDMA", "Cocaine" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 15, "commonMin": 30, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "comeup": { "min": 5, "max": 10, "units": "minutes" }, "peak": { "min": 30, "max": 60, "units": "minutes" }, "offset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 1, "max": 2.5, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } } ] }, { "name": "2-Fluorodeschloroketamine", "commonNames": [ "2-Fluoroketamine", "Fluoroketamine", "2-FK", "2-FDCK" ], "url": "https://psychonautwiki.org/wiki/2-Fluorodeschloroketamine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative" ], "interactions": { "dangerous": [ "Alcohol", "GHB", "GBL", "Opioids", "Tramadol" ], "unsafe": [], "uncertain": [ "Benzodiazepines", "MAOI" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 45, "strongMin": 100, "heavyMin": 175 }, "duration": { "onset": { "min": 1, "max": 3, "units": "minutes" }, "comeup": { "min": 5, "max": 10, "units": "minutes" }, "total": { "min": 1.5, "max": 3, "units": "hours" }, "afterglow": { "min": 1, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 25, "strongMin": 70, "heavyMin": 140 }, "duration": { "onset": { "min": 15, "max": 50, "units": "minutes" }, "peak": { "min": 50, "max": 100, "units": "minutes" }, "total": { "min": 2.5, "max": 5, "units": "hours" }, "afterglow": { "min": 3, "max": 8, "units": "hours" } } } ] }, { "name": "2-FMA", "commonNames": [ "2-FMA" ], "url": "https://psychonautwiki.org/wiki/2-FMA", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "research-chemical", "habit-forming" ], "summary": "A long-acting stimulant often compared to lisdexamphetamine. Thought to lack some of amphetamine's neurotoxic metabolites. Very functional, and for this reason it is commonly used for studying.", "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "comeup": { "min": 10, "max": 20, "units": "minutes" }, "peak": { "min": 1, "max": 3, "units": "hours" }, "offset": { "min": 1.5, "max": 3, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "comeup": { "min": 15, "max": 40, "units": "minutes" }, "peak": { "min": 2.5, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 7, "max": 9, "units": "hours" }, "afterglow": { "min": 4, "max": 12, "units": "hours" } } } ] }, { "name": "2-Methyl-AP-237", "commonNames": [ "2-Methyl-AP-237", "Apex", "2-MAP" ], "url": "https://psychonautwiki.org/wiki/2-Methyl-AP-237", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [], "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 15, "strongMin": 20, "heavyMin": 25 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "comeup": { "min": 10, "max": 40, "units": "minutes" }, "peak": { "min": 15, "max": 20, "units": "minutes" }, "offset": { "min": 5, "max": 60, "units": "minutes" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "2,5-DMA", "commonNames": [ "2,5-DMA", "DOH" ], "url": "https://psychonautwiki.org/wiki/2,5-DMA", "isApproved": true, "tolerance": { "full": "after ingestion over the couse of multiple days", "half": "3-5 days", "zero": "7-10 days", "halfToleranceInHours": 96, "zeroToleranceInHours": 204 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "stimulant" ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [] }, { "name": "25B-NBOH", "commonNames": [ "25B-NBOH" ], "url": "https://psychonautwiki.org/wiki/25B-NBOH", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "1 week", "zero": "2 weeks", "halfToleranceInHours": 168, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "potentially fatal at heavy dosages" ], "categories": [ "psychedelic", "research-chemical", "tentative" ], "summary": "A phenethylamine psychedelic and stimulant derivative of 2C-B, this compound is related to and has similar effects to 25b-NBOMe. It is significantly more potent than 2C-B but less potent than 25B-NBOMe. Overdoses of NBOH compounds may cause dangerous vasoconstriction. May induce uncomfortable body load.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [] }, { "name": "25B-NBOMe", "commonNames": [ "25B-NBOMe" ], "url": "https://psychonautwiki.org/wiki/25B-NBOMe", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "1 week", "zero": "2 weeks", "halfToleranceInHours": 168, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "potentially fatal at heavy dosages" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "Psychedelic Phenethylamine, active in the lower microgram range, that is not active orally.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Substituted amphetamines", "ΑMT", "Cocaine", "Dextromethorphan", "Tramadol" ], "uncertain": [ "2C-T-X", "5-MeO-xxt", "Caffeine", "Cannabis", "DOx", "MAOI", "MDMA", "Methoxetamine" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "µg", "lightMin": 25, "commonMin": 200, "strongMin": 350, "heavyMin": 500 } }, { "name": "sublingual", "dose": { "units": "µg", "lightMin": 50, "commonMin": 300, "strongMin": 500, "heavyMin": 700 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "comeup": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 4, "max": 6, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "25C-NBOH", "commonNames": [ "25C-NBOH" ], "url": "https://psychonautwiki.org/wiki/25C-NBOH", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "1 week", "zero": "2 weeks", "halfToleranceInHours": 168, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "potentially fatal at heavy dosages" ], "categories": [ "psychedelic", "research-chemical", "tentative" ], "summary": "A phenethylamine psychedelic and stimulant derivative of 2C-C, this compound is related and has similar effects to 25c-NBOMe. It is significantly more potent than 2C-C but less potent than 25c-NBOMe. Overdoses of NBOH compounds may cause dangerous vasoconstriction. May induce uncomfortable body load.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "sublingual", "dose": { "units": "µg", "lightMin": 100, "commonMin": 500, "strongMin": 750, "heavyMin": 1000 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 5, "max": 7, "units": "hours" }, "afterglow": { "min": 3, "max": 6, "units": "days" } } } ] }, { "name": "25C-NBOMe", "commonNames": [ "25C-NBOMe", "Cimbi-82", "NBOMe-2C-C", "2C-C-NBOMe" ], "url": "https://psychonautwiki.org/wiki/25C-NBOMe", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "7 days", "zero": "14 days", "halfToleranceInHours": 168, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "fatal at heavy dosages" ], "categories": [ "psychedelic", "research-chemical", "common" ], "summary": "A relatively new and popular research chemical. A short acting psychedelic related to 2C-C with similar effects to LSD, though more visual with less of a 'head-trip.' Frequently mis-sold as LSD. Causes an uncomfortable body load and has caused several deaths even within regular dose ranges.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Substituted amphetamines", "ΑMT", "Cocaine", "Dextromethorphan", "Tramadol" ], "uncertain": [ "2C-T-X", "5-MeO-xxt", "Caffeine", "Cannabis", "DOx", "MAOI", "MDMA", "Methoxetamine" ] }, "roas": [ { "name": "sublingual", "dose": { "units": "µg", "lightMin": 50, "commonMin": 300, "strongMin": 700, "heavyMin": 1000 }, "duration": { "onset": { "min": 0, "max": 15, "units": "minutes" }, "comeup": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 4, "max": 6, "units": "hours" }, "offset": { "min": 1, "max": 4, "units": "hours" }, "total": { "min": 8, "max": 10, "units": "hours" } } } ] }, { "name": "25D-NBOMe", "commonNames": [ "25D-NBOMe" ], "url": "https://psychonautwiki.org/wiki/25D-NBOMe", "isApproved": true, "crossTolerances": [ "psychedelics" ], "toxicities": [], "categories": [ "psychedelic", "research-chemical" ], "summary": "Uncommon analogue of 2C-D. Extremely potent psychedelic with stimulating qualities. Could cause dangerous vasoconstriction at high doses. May induce uncomfortable body load.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Substituted amphetamines", "ΑMT", "Cocaine", "Dextromethorphan", "Tramadol" ], "uncertain": [ "2C-T-X", "5-MeO-xxt", "Caffeine", "Cannabis", "DOx", "MAOI", "MDMA", "Methoxetamine" ] }, "roas": [ { "name": "sublingual", "dose": { "units": "µg", "lightMin": 300, "commonMin": 800, "strongMin": 1000, "heavyMin": 1200 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "25E-NBOH", "commonNames": [], "url": "https://psychonautwiki.org/wiki/25E-NBOH", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "psychedelic" ], "roas": [] }, { "name": "25I-NBOH", "commonNames": [ "25i-NBOH", "Cimbi-27" ], "url": "https://psychonautwiki.org/wiki/25I-NBOH", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "1 week", "zero": "2 weeks", "halfToleranceInHours": 168, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "potentially fatal at heavy dosages" ], "categories": [ "psychedelic", "research-chemical", "tentative" ], "summary": "A phenethylamine psychedelic and stimulant derivative of 2C-I, this compound is related and has similar effects to 25i-NBOMe. It is significantly more potent than 2C-I but less potent than 25i-NBOMe. Overdoses of NBOH compounds may cause dangerous vasoconstriction. May induce uncomfortable body load.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "sublingual", "dose": { "units": "µg", "lightMin": 50, "commonMin": 500, "strongMin": 900, "heavyMin": 1400 }, "duration": { "onset": { "min": 15, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 2, "max": 3.5, "units": "hours" }, "offset": { "min": 1.5, "max": 2.5, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 3, "max": 12, "units": "days" } } } ] }, { "name": "25I-NBOMe", "commonNames": [ "25i-NBOMe", "25i", "Cimbi-5" ], "url": "https://psychonautwiki.org/wiki/25I-NBOMe", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "1 week", "zero": "2 weeks", "halfToleranceInHours": 168, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "potentially fatal at heavy dosages" ], "categories": [ "psychedelic", "research-chemical", "common" ], "summary": "A relatively new and popular research chemical with psychedelic properties. Users report an uncomfortable body load with very strong visuals, though with less of a mental aspect than most psychedelics. Commonly mis-sold as LSD, since it is much cheaper to produce. Is considered quite unsafe, and has caused several deaths at 'regular' doses.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Substituted amphetamines", "ΑMT", "Cocaine", "Dextromethorphan", "Tramadol" ], "uncertain": [ "2C-T-X", "5-MeO-xxt", "Caffeine", "Cannabis", "DOx", "MAOI", "MDMA", "Methoxetamine" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "µg", "lightMin": 50, "commonMin": 500, "strongMin": 700 }, "duration": { "onset": { "min": 5, "max": 10, "units": "minutes" }, "comeup": { "min": 10, "max": 30, "units": "minutes" }, "peak": { "min": 60, "max": 120, "units": "minutes" }, "offset": { "min": 120, "max": 180, "units": "minutes" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 1, "max": 7, "units": "days" } } }, { "name": "sublingual", "dose": { "units": "µg", "lightMin": 50, "commonMin": 500, "strongMin": 700, "heavyMin": 1000 }, "duration": { "onset": { "min": 15, "max": 120, "units": "minutes" }, "comeup": { "min": 30, "max": 120, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 1, "max": 4, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" }, "afterglow": { "min": 3, "max": 6, "units": "days" } } } ] }, { "name": "25N-NBOMe", "commonNames": [ "25N-NBOMe" ], "url": "https://psychonautwiki.org/wiki/25N-NBOMe", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "potentially fatal at heavy dosages" ], "categories": [ "psychedelic", "research-chemical", "tentative" ], "summary": "A rare, highly potent and yellow psychedelic phenethylamine and derivative of 2C-N. Effects are similar to other NBOMe compounds, with hallucinations, intense body load, stimulation and vasoconstriction. At high doses vasoconstriction can be dangerous, exercise caution.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Substituted amphetamines", "ΑMT", "Cocaine", "Dextromethorphan", "Tramadol" ], "uncertain": [ "2C-T-X", "5-MeO-xxt", "Caffeine", "Cannabis", "DOx", "MAOI", "MDMA", "Methoxetamine" ] }, "roas": [ { "name": "sublingual", "dose": { "units": "µg", "lightMin": 100, "commonMin": 300, "strongMin": 800, "heavyMin": 1300 }, "duration": { "onset": { "min": 45, "max": 75, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 5, "max": 10, "units": "hours" }, "afterglow": { "min": 5, "max": 10, "units": "hours" } } } ] }, { "name": "2C-B", "commonNames": [ "2C-B", "Nexus", "Bees" ], "url": "https://psychonautwiki.org/wiki/2C-B", "isApproved": true, "crossTolerances": [], "addictionPotential": "non-addictive with a low potential for abuse", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "entactogen", "common" ], "summary": "A popular psychedelic in the phenethylamine family. Provides empathic experiences at lower doses and strong visual and psychedelic experiences at higher doses. Commonly used as a party drug as it is more clear-headed than most psychedelics. 2C-B has been in use since the early 1990s", "effectsSummary": "Perceptions and feelings become more intense. From 10-15 mg (snorted already from 7 mg), the effect usually takes on a hallucinogenic character. The boundaries between inside and outside can dissolve. Often moving coloured patterns and luminous fields around objects and persons are perceived. However, the intoxication is felt to be less profound than with LSD.", "dosageRemark": "2C-B is effective even in small doses; a gradual approach to the individual dose is recommended. Over the 12 to 24 milligram range, every 2 milligrams can make a profound increase or change of response. Doses above 35 mg can be experienced as unpleasantly strong even by experienced users.", "generalRisks": "The pupils dilate, blood pressure rises and nausea, sweating and dizziness may occur. Some users report stomach and intestinal problems, and mild allergic reactions (such as coughing due to increased mucus production) may occur. Disorientation, confusion and feelings of anxiety, even fear of death, are risks on a psychological level.", "longtermRisks": "There are no research results on long-term risks so far.", "saferUse": [ "2C-B seems very setting-dependent and is only suitable for parties to a limited extent.", "Be aware of set and setting: Use 2C-B only in places where you feel comfortable and safe. Do not use if you are afraid of the drug.", "Never consume 2C-B alone and only when you feel mentally and physically well and are well rested.", "Do not add more, dose carefully.", "Drink enough water during the trip.", "Follow the safer-sniffing rules when sniffing. Attention, 2C-B burns painfully in the nose!", "People with cardiovascular diseases and diabetics are at increased risk when consuming 2C-B." ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 8, "strongMin": 12, "heavyMin": 23 }, "duration": { "onset": { "min": 0, "max": 20, "units": "minutes" }, "total": { "min": 4, "max": 7, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 25, "heavyMin": 45 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "comeup": { "min": 60, "max": 90, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 2.5, "max": 3.5, "units": "hours" }, "total": { "min": 5, "max": 7, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "rectal", "dose": { "units": "mg", "lightMin": 1, "commonMin": 8, "strongMin": 12, "heavyMin": 23 }, "duration": { "onset": { "min": 0, "max": 20, "units": "minutes" }, "total": { "min": 4, "max": 7, "units": "hours" } } } ] }, { "name": "2C-B-FLY", "commonNames": [ "2C-B-FLY" ], "url": "https://psychonautwiki.org/wiki/2C-B-FLY", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "Psychedelic phenethylamine that is the dihydrodifuran analog of 2C-B.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 10, "strongMin": 18, "heavyMin": 25 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "comeup": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 7, "max": 12, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "2C-C", "commonNames": [ "2C-C" ], "url": "https://psychonautwiki.org/wiki/2C-C", "isApproved": true, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A short-acting psychedelic research chemical of the 2c-x family. Often described as being less stimulating than the other 2c-x, and is a relatively unique psychedelic in this respect.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 30, "strongMin": 50, "heavyMin": 90 }, "duration": { "onset": { "min": 20, "max": 45, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 4, "max": 12, "units": "hours" } } } ] }, { "name": "2C-D", "commonNames": [ "2C-D", "2C-M", "LE-25" ], "url": "https://psychonautwiki.org/wiki/2C-D", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A fairly generic psychedelic famed for being usable as \"psychedelic tofu\". Little character of its own but pleasant in combinations.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 25, "strongMin": 50, "heavyMin": 100 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 0.5, "max": 1.5, "units": "hours" }, "total": { "min": 3, "max": 5, "units": "hours" }, "afterglow": { "min": 1, "max": 4, "units": "hours" } } } ] }, { "name": "2C-E", "commonNames": [ "2C-E", "Eternity" ], "url": "https://psychonautwiki.org/wiki/2C-E", "isApproved": true, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical", "common" ], "summary": "An intense psychedelic drug with very strong visuals, sometimes criticised for its relatively uncomfortable body load. Otherwise, effects are comparable to other 2c-x drugs.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 4, "strongMin": 7, "heavyMin": 14 }, "duration": { "onset": { "min": 1, "max": 2, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 10, "strongMin": 15, "heavyMin": 30 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "2C-H", "commonNames": [ "2C-H", "DMPEA" ], "url": "https://psychonautwiki.org/wiki/2C-H", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3-5 days", "zero": "7-10 days", "halfToleranceInHours": 96, "zeroToleranceInHours": 204 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "stimulant" ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [] }, { "name": "2C-I", "commonNames": [ "2C-I" ], "url": "https://psychonautwiki.org/wiki/2C-I", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3-5 days", "zero": "7-10 days", "halfToleranceInHours": 96, "zeroToleranceInHours": 204 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A psychedelic similar to the more well-known 2C-B. Users frequently report very vivid and bright open-eye visuals and more mild closed-eye visuals compared to 2C-B and other drugs in the 2C family. Can also be more stimulating than 2C-B along with having a slight body load for some users. Less safe at high doses compared to 2C-B", "effectsSummary": "Perceptions and feelings become more intense. From 10-15 mg (snorted already from 7 mg), the effect usually takes on a hallucinogenic character. The boundaries between inside and outside can dissolve. Often moving coloured patterns and luminous fields around objects and persons are perceived. However, the intoxication is felt to be less profound than with LSD.", "dosageRemark": "2C-I is effective even in small doses; even 2 mg more or less can make a big difference in the effect experienced; a gradual approach to the individual dose is recommended. Doses above 35 mg can be experienced as unpleasantly strong even by experienced users.", "generalRisks": "The pupils dilate, blood pressure rises and nausea, sweating and dizziness may occur. Some users report stomach and intestinal problems, and mild allergic reactions (such as coughing due to increased mucus production) may occur. Disorientation, confusion and feelings of anxiety, even fear of death, are risks on a psychological level.", "longtermRisks": "There are no research results on long-term risks so far.", "saferUse": [ "2C-I seems very setting-dependent and is only suitable for parties to a limited extent.", "Be aware of set and setting: Use 2C-I only in places where you feel comfortable and safe. Do not use if you are afraid of the drug.", "Never consume 2C-I alone and only when you feel mentally and physically well and are well rested.", "Do not add more, dose carefully.", "Drink enough water during the trip.", "Follow the safer-sniffing rules when sniffing.", "People with cardiovascular diseases and diabetics are at increased risk when consuming 2C-I." ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 10, "strongMin": 20, "heavyMin": 30 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "2C-P", "commonNames": [ "2C-P" ], "url": "https://psychonautwiki.org/wiki/2C-P", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "low potential for abuse and dependence", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A synthetic phenylethlyamine that is sometimes compared in effects to 2C-E, yet with a much longer duration. With a much more pronouced bodyload. Is one of the most potent of the 2C-X series.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 6, "strongMin": 10, "heavyMin": 16 }, "duration": { "onset": { "min": 1, "max": 3, "units": "hours" }, "comeup": { "min": 2, "max": 4, "units": "hours" }, "peak": { "min": 4, "max": 8, "units": "hours" }, "offset": { "min": 3, "max": 6, "units": "hours" }, "total": { "min": 10, "max": 20, "units": "hours" }, "afterglow": { "min": 8, "max": 48, "units": "hours" } } } ] }, { "name": "2C-T", "commonNames": [ "2C-T", "Tesseract" ], "url": "https://psychonautwiki.org/wiki/2C-T", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "no negative health effects attributed to trying this drug" ], "categories": [ "psychedelic", "entactogen", "research-chemical", "tentative" ], "summary": "A very rare psychedelic phenylethylamine.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 60, "strongMin": 100, "heavyMin": 125 }, "duration": { "onset": { "min": 30, "max": 45, "units": "minutes" }, "peak": { "min": 30, "max": 115, "units": "minutes" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 1, "max": 2, "units": "hours" } } } ] }, { "name": "2C-T-2", "commonNames": [ "2C-T-2", "Rosy" ], "url": "https://psychonautwiki.org/wiki/2C-T-2", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "no negative health effects attributed to trying this drug" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "An unusual psychedelic with similar effects to 2C-B and a slightly longer duration, but maligned because of some deaths in the 2000s. Also similar to 2c-t-7, but with a shorter duration. Potentially unsafe with stimulants and empathogens.", "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 10, "strongMin": 20, "heavyMin": 25 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 3, "max": 7, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 10, "strongMin": 20, "heavyMin": 30 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2.5, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "2C-T-21", "commonNames": [ "2C-T-21", "Aurora" ], "url": "https://psychonautwiki.org/wiki/2C-T-21", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [], "categories": [ "psychedelic", "research-chemical", "tentative" ], "summary": "A rare psychedelic phenethylamine.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 12, "heavyMin": 15 }, "duration": { "onset": { "min": 90, "max": 120, "units": "minutes" }, "peak": { "min": 3, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 10, "max": 12, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "2C-T-7", "commonNames": [ "2C-T-7", "Beautiful", "Blue Mystic", "7th Heaven" ], "url": "https://psychonautwiki.org/wiki/2C-T-7", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [], "categories": [ "psychedelic", "research-chemical", "entactogen" ], "summary": "A relatively uncommon psychedelic phenethylamine and possible MAOI. Long lasting, an possesses an unpredictable dosage curve. Questionable safety in combination with most things.", "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 15 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "comeup": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 3, "max": 7, "units": "hours" }, "afterglow": { "min": 1, "max": 2, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 15, "strongMin": 25, "heavyMin": 40 }, "duration": { "onset": { "min": 60, "max": 90, "units": "minutes" }, "comeup": { "min": 10, "max": 30, "units": "minutes" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" }, "afterglow": { "min": 2, "max": 8, "units": "hours" } } } ] }, { "name": "2M2B", "commonNames": [ "2M2B", "2-methyl-2-butanol" ], "url": "https://psychonautwiki.org/wiki/2M2B", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "GABA", "depressants" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "depressant" ], "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mL", "lightMin": 0.5, "commonMin": 5, "strongMin": 10, "heavyMin": 15 }, "duration": { "peak": { "min": 6, "max": 8, "units": "hours" }, "offset": { "min": 4, "max": 6, "units": "hours" }, "total": { "min": 8, "max": 14, "units": "hours" } } } ] }, { "name": "3-Cl-PCP", "commonNames": [], "url": "https://psychonautwiki.org/wiki/3-Cl-PCP", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "4 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 132, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for adverse side effects such as psychosis", "toxicities": [ "toxic dosage is unknown" ], "categories": [ "dissociative" ], "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [] }, { "name": "3-FA", "commonNames": [ "3-FA", "PAL-353" ], "url": "https://psychonautwiki.org/wiki/3-FA", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 10 days", "halfToleranceInHours": 120, "zeroToleranceInHours": 132 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "research-chemical", "habit-forming", "tentative" ], "summary": "A stimulant that is close to equipotent with methamphetamine and acts as a monoamine releasing agent , but has more selectivity for dopamine/noradrenaline over serotonin.", "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 30, "strongMin": 50, "heavyMin": 70 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "3-FEA", "commonNames": [ "3-FEA" ], "url": "https://psychonautwiki.org/wiki/3-FEA", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "2 - 3 days", "zero": "3-7 days", "halfToleranceInHours": 60, "zeroToleranceInHours": 120 }, "crossTolerances": [ "dopamine", "serotonin|serotonergic", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "research-chemical", "habit-forming", "tentative" ], "summary": "A novel fluorinated amphetamine with serotonergic properties. Effects are similar to 4-FA, in that it provides slight dopamine and norepinephrine release or reuptake inhibition, as well as serotonin release and reuptake inhibition. Effects on the serotonin side are more pronounced than dopamine and norepinephrine, the latter two being almost negligibly.", "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 15, "commonMin": 35, "strongMin": 50, "heavyMin": 60 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "comeup": { "min": 5, "max": 10, "units": "minutes" }, "peak": { "min": 30, "max": 60, "units": "minutes" }, "offset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 1, "max": 2, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 15, "commonMin": 35, "strongMin": 70, "heavyMin": 90 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 6, "max": 12, "units": "hours" } } } ] }, { "name": "3-FMA", "commonNames": [ "3-FMA" ], "url": "https://psychonautwiki.org/wiki/3-FMA", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 10 days", "halfToleranceInHours": 120, "zeroToleranceInHours": 132 }, "crossTolerances": [ "dopamine", "serotonin|serotonergic", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "research-chemical", "habit-forming" ], "summary": "Stimulant drug in the amphetamine family", "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 35, "heavyMin": 50 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 3, "max": 7, "units": "hours" }, "afterglow": { "min": 6, "max": 12, "units": "hours" } } } ] }, { "name": "3-FPM", "commonNames": [ "3-FPM", "PAL-593" ], "url": "https://psychonautwiki.org/wiki/3-FPM", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "research-chemical", "habit-forming" ], "summary": "A functional stimulant related to phenmetrazine. Effects similar to amphetamine, but longer and more focused. Observed as being relatively benign in low doses, but seems to cause worrying health effects for heavy users. Pain from insufflation is eye-wateringly intense, but short.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 35, "heavyMin": 50 }, "duration": { "total": { "min": 3, "max": 6, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 30, "strongMin": 60, "heavyMin": 90 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 30, "max": 90, "units": "minutes" } } } ] }, { "name": "3-HO-PCE", "commonNames": [ "3-HO-PCE", "Hydroxyeticyclidine" ], "url": "https://psychonautwiki.org/wiki/3-HO-PCE", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "4 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 132, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a moderate potential for adverse side effects such as psychosis", "toxicities": [ "toxic dosage is unknown" ], "categories": [ "dissociative", "research-chemical", "habit-forming", "tentative" ], "summary": "A rare and very potent PCP analogue, eight times more potent than PCP as NMDA receptor antagonist and also a μ-opioid receptor agonist. Similar in structure to methoxetamine.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 15, "heavyMin": 25 }, "duration": { "total": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "3-HO-PCP", "commonNames": [ "3-HO-PCP", "Hydroxyphencyclidine" ], "url": "https://psychonautwiki.org/wiki/3-HO-PCP", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "4 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 132, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for adverse side effects such as psychosis", "toxicities": [ "toxic dosage is unknown" ], "categories": [ "dissociative", "research-chemical", "habit-forming", "tentative" ], "summary": "An arylcyclohexamine dissociative analogue of PCP, this drug is relatively uncommon, and little information is available. It is reported to not only have dissociative activity but also be an opioid. Some trip reports suggest very negative side-effects including intense muscle tension.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 4, "strongMin": 6, "heavyMin": 8 }, "duration": { "comeup": { "min": 60, "max": 90, "units": "minutes" }, "total": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "3-MeO-PCE", "commonNames": [ "3-MeO-PCE", "Methoxyeticyclidine" ], "url": "https://psychonautwiki.org/wiki/3-MeO-PCE", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociatives" ], "addictionPotential": "highly addictive with a high potential for adverse side effects such as psychosis", "toxicities": [ "toxic dosage is unknown" ], "categories": [ "dissociative", "research-chemical", "habit-forming", "tentative" ], "summary": "3-MeO-PCP with a change of a ring replacement. Slightly more potent than 3-MeO-PCP.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 6, "strongMin": 12, "heavyMin": 20 }, "duration": { "onset": { "min": 3, "max": 15, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 1.5, "max": 2, "units": "hours" }, "offset": { "min": 45, "max": 60, "units": "minutes" }, "total": { "min": 3, "max": 5, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 8, "strongMin": 15, "heavyMin": 25 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "comeup": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } } ] }, { "name": "3-MeO-PCMo", "commonNames": [], "url": "https://psychonautwiki.org/wiki/3-MeO-PCMo", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative" ], "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 200, "strongMin": 300, "heavyMin": 400 }, "duration": { "onset": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 5, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 3, "units": "hours" } } } ] }, { "name": "3-MeO-PCP", "commonNames": [ "3-MeO-PCP", "3-MeO" ], "url": "https://psychonautwiki.org/wiki/3-MeO-PCP", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "produces dependence with chronic use and has a high potential for abuse", "toxicities": [ "toxic dosage is unknown" ], "categories": [ "dissociative", "research-chemical", "habit-forming", "common" ], "summary": "A potent dissociative often compared to MXE but with a longer duration, much less sedating effects and causing an overall different experience. Users have reported effects as being similar to PCP. Roughtly ten times more potent than 4-MeO-PCP.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 15 }, "duration": { "onset": { "min": 5, "max": 30, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 1.5, "max": 2, "units": "hours" }, "offset": { "min": 45, "max": 60, "units": "minutes" }, "total": { "min": 3, "max": 5, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 8, "strongMin": 15, "heavyMin": 25 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "comeup": { "min": 45, "max": 120, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 2, "commonMin": 10, "strongMin": 20, "heavyMin": 25 }, "duration": { "total": { "min": 45, "max": 120, "units": "minutes" } } } ] }, { "name": "3-MMC", "commonNames": [ "3-MMC", "Metaphedrone" ], "url": "https://psychonautwiki.org/wiki/3-MMC", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "extremely addictive with a high potential for abuse", "toxicities": [], "categories": [ "entactogen", "stimulant", "habit-forming" ], "summary": "A euphoric stimulant similar to mephedrone but said to lack much of the \"magic.\" Never gained the same popularity. Slightly less potent.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 10, "commonMin": 40, "strongMin": 60, "heavyMin": 120 }, "duration": { "onset": { "min": 5, "max": 10, "units": "minutes" }, "comeup": { "min": 10, "max": 20, "units": "minutes" }, "peak": { "min": 1, "max": 1.5, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 2.5, "max": 4.5, "units": "hours" }, "afterglow": { "min": 1, "max": 1.5, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 150, "strongMin": 250, "heavyMin": 350 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "3,4-CTMP", "commonNames": [ "3,4-CTMP" ], "url": "https://psychonautwiki.org/wiki/3,4-CTMP", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant", "research-chemical", "habit-forming" ], "summary": "A strong stimulant, NDRI and analogue of methylphenidate. Has increased in popularity in recent years. Said to be seven times more potent than methylphenidate but with a slower onset, however discrimination studies have found it to be more addictive than cocaine.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 4, "strongMin": 6, "heavyMin": 8 }, "duration": { "onset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 6, "max": 18, "units": "hours" }, "afterglow": { "min": 2, "max": 24, "units": "hours" } } } ] }, { "name": "3C-E", "commonNames": [ "3C-E", "3C-Escaline" ], "url": "https://psychonautwiki.org/wiki/3C-E", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical", "stimulant" ], "summary": "Three-Carbon Analog of Escaline. Substituted Amphetamine.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 15, "commonMin": 35, "strongMin": 60, "heavyMin": 70 }, "duration": { "onset": { "min": 5, "max": 90, "units": "minutes" }, "peak": { "min": 4, "max": 7, "units": "hours" }, "offset": { "min": 2, "max": 5, "units": "hours" }, "total": { "min": 5, "max": 12, "units": "hours" }, "afterglow": { "min": 3, "max": 5, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 40, "strongMin": 60, "heavyMin": 80 }, "duration": { "onset": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 4, "max": 8, "units": "hours" }, "offset": { "min": 3, "max": 6, "units": "hours" }, "total": { "min": 10, "max": 16, "units": "hours" }, "afterglow": { "min": 3, "max": 6, "units": "hours" } } } ] }, { "name": "3C-P", "commonNames": [], "url": "https://psychonautwiki.org/wiki/3C-P", "isApproved": false, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "stimulant", "research-chemical" ], "summary": "Rather new and uncommon stimulant, psychedelic and amphetamine with properties similar to the 2Cx class of drugs. 3-carbon homologue of proscaline.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg" }, "duration": { "onset": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 4, "max": 8, "units": "hours" }, "offset": { "min": 3, "max": 6, "units": "hours" }, "total": { "min": 10, "max": 16, "units": "hours" }, "afterglow": { "min": 3, "max": 6, "units": "hours" } } } ] }, { "name": "4-AcO-DET", "commonNames": [ "4-AcO-DET", "4-Acetoxy-DET", "Ethacetin" ], "url": "https://psychonautwiki.org/wiki/4-AcO-DET", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "tentative", "research-chemical" ], "summary": "Rare drug that is of the tryptamine family, can be comparable to Psilocybin. Expected to quickly hydrolyzed into the free phenolic 4-HO-DET.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 20, "heavyMin": 35 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 1, "max": 1.5, "units": "hours" }, "peak": { "min": 1.5, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 7, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "4-AcO-DiPT", "commonNames": [ "4-AcO-DiPT", "4-Acetoxy-DiPT", "Ipracetin", "Aces" ], "url": "https://psychonautwiki.org/wiki/4-AcO-DiPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "An uncommon psychedelic tryptamine with a short history of human use, also known as Ipracetin. Possibly first synthesised by Alexander Shulgin. Some reports of heavy nausea, with effects comparable to 2c-b and mushrooms.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 15, "strongMin": 30, "heavyMin": 45 }, "duration": { "onset": { "min": 15, "max": 40, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1.5, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 3, "max": 4, "units": "hours" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "4-AcO-DMT", "commonNames": [ "4-AcO-DMT", "4-Acetoxy-DMT", "Psilacetin", "O-Acetylpsilocin", "Synthetic mushrooms" ], "url": "https://psychonautwiki.org/wiki/4-AcO-DMT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "zero": "7 days", "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "non-addictive with low potential for abuse", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical", "common" ], "summary": "A prodrug for Psilocin with extremely similar effects as Mushrooms.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 25, "heavyMin": 50 }, "duration": { "onset": { "min": 5, "max": 25, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 3, "max": 5, "units": "hours" }, "afterglow": { "min": 2, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 25, "heavyMin": 45 }, "duration": { "onset": { "min": 15, "max": 40, "units": "minutes" }, "comeup": { "min": 30, "max": 75, "units": "minutes" }, "peak": { "min": 2, "max": 3.5, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 7, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } } ] }, { "name": "4-AcO-MET", "commonNames": [ "4-AcO-MET", "4-Acetoxy-MET", "Metacetin", "O-Acetylmetocin" ], "url": "https://psychonautwiki.org/wiki/4-AcO-MET", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A rare psychedelic tryptamine which is thought to be metabolised into 4-HO-MET. Onset and duration, intensity will vary but effect profile is largely the same.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "4-AcO-MiPT", "commonNames": [ "4-AcO-MiPT", "Mipracetin", "O-Acetylmiprocin" ], "url": "https://psychonautwiki.org/wiki/4-AcO-MiPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "tentative", "entactogen", "research-chemical" ], "summary": "A quite potent tryptamine that has be related to having \"shroom-like\" visuals. Yet without much bodyload. Very hydroscopic. Seems to be quite safe in dosing. Similar to the likes of 2C-B.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 20, "heavyMin": 35 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 1.5, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "4-FA", "commonNames": [ "4-FA", "4-FMP", "PAL-303", "Flux" ], "url": "https://psychonautwiki.org/wiki/4-FA", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulants" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [], "categories": [ "entactogen", "stimulant", "research-chemical", "habit-forming", "common" ], "summary": "An empathogen commonly used in place of MDMA, having a similar duration of empathogenic effects. This drug, however, has a longer stimulant \"tail,\" during which effects are more like those of amphetamines. Not to be confused with 4-FMA, which has a similar potency, but is not particularly empathogenic.", "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 40, "commonMin": 100, "strongMin": 130, "heavyMin": 150 }, "duration": { "onset": { "min": 45, "max": 75, "units": "minutes" }, "comeup": { "min": 30, "max": 75, "units": "minutes" }, "peak": { "min": 2.5, "max": 3.5, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 6, "max": 12, "units": "hours" } } } ] }, { "name": "4-FMA", "commonNames": [ "4-FMA" ], "url": "https://psychonautwiki.org/wiki/4-FMA", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "research-chemical", "habit-forming" ], "summary": "A stimulant with some empathogenic properties, and analogue of Methamphetamine with similar effects. Reported to be less effective than 2-FMA and related compounds. Little is known about the pharmacological effects of this compound. Not to be confused with 4-FA, which has a different effect profile, despite similar potency.", "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 50, "strongMin": 100, "heavyMin": 125 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 2, "max": 5, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 3, "max": 12, "units": "hours" } } } ] }, { "name": "4-HO-DET", "commonNames": [ "4-HO-DET", "Ethocin", "CZ-74" ], "url": "https://psychonautwiki.org/wiki/4-HO-DET", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A rare compound first produced by Albert Hoffman, also known as ethocin. Structurally related to 4-HO-MET (metocin) and psilocin (4-HO-DMT), this drug has similar psychedelic effects but little recorded human usage. Probably similar to mushrooms. Potentially stimulating.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 30, "heavyMin": 45 }, "duration": { "onset": { "min": 20, "max": 45, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2.5, "max": 3.5, "units": "hours" }, "offset": { "min": 1.5, "max": 2, "units": "hours" }, "total": { "min": 5, "max": 7, "units": "hours" }, "afterglow": { "min": 1, "max": 4, "units": "hours" } } } ] }, { "name": "4-HO-DiPT", "commonNames": [ "4-HO-DiPT", "Iprocin" ], "url": "https://psychonautwiki.org/wiki/4-HO-DiPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A psychedelic tryptamine also known as iprocin. A homologue of psilocin, this drug likely has similar effects to psychedelic mushrooms. Said to have a rapid onset and relatively short duration for a drug of its class.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 10, "strongMin": 20, "heavyMin": 30 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "4-HO-DPT", "commonNames": [ "4-HO-DPT", "Procin" ], "url": "https://psychonautwiki.org/wiki/4-HO-DPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "tentative", "research-chemical" ], "summary": "A psychedelic hallucinogenic first synthesized by alexander shulgin. At light doses it causes enhanced cognition and appreciation for things like art and music while high doses cause visuals. The drug is known to cause a bodyload.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 25, "heavyMin": 35 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 30, "max": 45, "units": "minutes" }, "peak": { "min": 1, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 60, "strongMin": 90, "heavyMin": 130 }, "duration": { "onset": { "min": 45, "max": 60, "units": "minutes" }, "comeup": { "min": 60, "max": 120, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" } } } ] }, { "name": "4-HO-EPT", "commonNames": [ "4-HO-EPT", "Eprocin" ], "url": "https://psychonautwiki.org/wiki/4-HO-EPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "tentative" ], "summary": "The 4-Hydroxy version of EPT. Slightly more potent than the prior.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 15, "commonMin": 30, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 3, "max": 7, "units": "hours" } } } ] }, { "name": "4-HO-MET", "commonNames": [ "4-HO-MET", "Metocin", "Methylcybin", "Colour" ], "url": "https://psychonautwiki.org/wiki/4-HO-MET", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical", "common" ], "summary": "A lesser known psychedelic tryptamine. Functional analogue of Psilocin. Very poorly soluble in water and alcohol.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 25, "heavyMin": 45 }, "duration": { "onset": { "min": 15, "max": 40, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 12, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 5, "commonMin": 25, "strongMin": 35, "heavyMin": 60 }, "duration": { "onset": { "min": 15, "max": 120, "units": "seconds" }, "total": { "min": 25, "max": 45, "units": "minutes" } } } ] }, { "name": "4-HO-MiPT", "commonNames": [ "4-HO-MiPT", "Miprocin" ], "url": "https://psychonautwiki.org/wiki/4-HO-MiPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A reasonably popular tryptamine deriviative and Psilocin analogue, first synthesised by Alexander Shulgin. It has been reported as having comparable effects to psychedelic mushrooms, though with a shorter duration.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 25, "heavyMin": 35 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 12, "units": "hours" } } } ] }, { "name": "4-HO-MPT", "commonNames": [ "4-HO-MPT", "Meprocin" ], "url": "https://psychonautwiki.org/wiki/4-HO-MPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "tentative", "research-chemical" ], "summary": "Psychedelic drug of the tryptamine class. Higher homologue of Psilocin, and is the 4-hydroxy analogue of N-Methyl-N-Propyltryptamine.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 5, "max": 7, "units": "hours" }, "afterglow": { "min": 2, "max": 12, "units": "hours" } } } ] }, { "name": "4-MeO-PCP", "commonNames": [ "4-MeO-PCP", "Methoxydine" ], "url": "https://psychonautwiki.org/wiki/4-MeO-PCP", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative", "research-chemical", "habit-forming" ], "summary": "An arylcyclohexamine dissociative anaesthetic related to PCP. First discovered in the 1960s by Parke-Davis, it was introduced to the RC market in 2008. Reported to be less potent than PCP. It is not commonly seen, but has seen some increase in popularity with the inavailability of other dissociatives.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 15, "commonMin": 75, "strongMin": 150, "heavyMin": 150 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 3, "max": 6, "units": "hours" }, "offset": { "min": 3, "units": "hours" }, "total": { "min": 12, "max": 18, "units": "hours" }, "afterglow": { "min": 3, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 100, "strongMin": 170, "heavyMin": 250 }, "duration": { "onset": { "min": 45, "max": 120, "units": "minutes" }, "comeup": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 3, "max": 7, "units": "hours" }, "offset": { "min": 6, "max": 10, "units": "hours" }, "total": { "min": 12, "max": 20, "units": "hours" } } } ] }, { "name": "4F-EPH", "commonNames": [ "4F-EPH", "4FEPH" ], "url": "https://psychonautwiki.org/wiki/4F-EPH", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 15, "heavyMin": 30 }, "duration": { "onset": { "min": 10, "max": 25, "units": "minutes" }, "total": { "min": 5, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 12, "units": "hours" } } } ] }, { "name": "4F-MPH", "commonNames": [ "4F-MPH" ], "url": "https://psychonautwiki.org/wiki/4F-MPH", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 8, "strongMin": 14, "heavyMin": 20 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 8, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 15, "heavyMin": 20 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 5, "max": 10, "units": "hours" } } } ] }, { "name": "5-APB", "commonNames": [ "5-APB" ], "url": "https://psychonautwiki.org/wiki/5-APB", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "psychedelic", "research-chemical", "habit-forming" ], "summary": "A triple monoamine reuptake inhibitor. This agonism for 5-HT2B makes it likely that 5-APB would be cardiotoxic with long term use, as seen in other 5-HT2B agonists such as fenfluramine and MDMA.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "SNRIs", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 60, "strongMin": 80, "heavyMin": 100 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 1.5, "max": 3, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 6, "max": 48, "units": "hours" } } } ] }, { "name": "5-Hydroxytryptophan", "commonNames": [ "5-HTP", "Oxitriptan", "Cincofarm", "Levothym", "Levotonine", "Oxyfan", "Telesol", "Tript-OH", "Triptum" ], "url": "https://psychonautwiki.org/wiki/5-Hydroxytryptophan", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "nootropic" ], "interactions": { "dangerous": [ "SSRIs", "SNRIs", "Serotonin releasers", "MAOI", "Tricyclic antidepressants", "Tramadol" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 100, "strongMin": 300, "heavyMin": 500 } } ] }, { "name": "5-MAPB", "commonNames": [ "5-MAPB" ], "url": "https://psychonautwiki.org/wiki/5-MAPB", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "psychedelic", "stimulant", "research-chemical", "habit-forming" ], "summary": "An empathogen structurally similar to MDMA. Typically more visual than MDMA. Often reported to be much less stimulating and more relaxing than most other stimulating empathogens. Less psychedelic than 6-APB. Much longer lasting than MDMA.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "SNRIs", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 60, "strongMin": 80, "heavyMin": 100 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 1.5, "max": 3, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 6, "max": 48, "units": "hours" } } } ] }, { "name": "5-MeO-DALT", "commonNames": [ "5-MeO-DALT", "Foxtrot" ], "url": "https://psychonautwiki.org/wiki/5-MeO-DALT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A strange drug with an unknown mechanism of action. Some psychedelic effects alongside some effects non-characteristic of psychedelics like appetite enhancement. Reported as having rapid, intense and short acting entheogenic effects.", "interactions": { "dangerous": [ "ΑMT", "MAOI", "PCP" ], "unsafe": [ "Substituted amphetamines", "Cocaine", "Dextromethorphan", "Tramadol" ], "uncertain": [ "2C-T-X", "2C-X", "Cannabis", "DOx", "MDMA", "Mescaline", "25x-NBOMe" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 4, "commonMin": 12, "strongMin": 25, "heavyMin": 35 }, "duration": { "total": { "min": 3, "max": 6, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 3, "commonMin": 5, "strongMin": 10 }, "duration": { "onset": { "min": 15, "max": 60, "units": "seconds" }, "peak": { "min": 1, "max": 5, "units": "minutes" }, "offset": { "min": 5, "max": 10, "units": "minutes" }, "total": { "min": 15, "max": 20, "units": "minutes" }, "afterglow": { "min": 5, "max": 10, "units": "minutes" } } } ] }, { "name": "5-MeO-DiBF", "commonNames": [ "5-MeO-DiBF" ], "url": "https://psychonautwiki.org/wiki/5-MeO-DiBF", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic" ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 80, "strongMin": 110, "heavyMin": 140 }, "duration": { "peak": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "5-MeO-DiPT", "commonNames": [ "5-MeO-DiPT", "Foxy Methoxy", "Foxy" ], "url": "https://psychonautwiki.org/wiki/5-MeO-DiPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical", "entactogen" ], "summary": "5-methoxy-di isopropyl tryptamine, also known as 'foxy', a psychedelic tryptamine related to DMT, which distorts visual and audio perception. Reported to have a heavy body load at high doses, it behaves similarly to other drugs of its class.", "interactions": { "dangerous": [ "ΑMT", "MAOI", "PCP" ], "unsafe": [ "Substituted amphetamines", "Cocaine", "Dextromethorphan", "Tramadol" ], "uncertain": [ "2C-T-X", "2C-X", "Cannabis", "DOx", "MDMA", "Mescaline", "25x-NBOMe" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 10, "strongMin": 15, "heavyMin": 20 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "5-MeO-DMT", "commonNames": [ "5-MeO-DMT", "The God Molecule", "Toad", "Jaguar" ], "url": "https://psychonautwiki.org/wiki/5-MeO-DMT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "1 hour", "zero": "2 hours", "halfToleranceInHours": 1, "zeroToleranceInHours": 2 }, "crossTolerances": [], "addictionPotential": "non-addictive with a low abuse potential", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A powerful psychedelic tryptamine found in many species of plants and some toad venom, with a history of use by native South Americans spanning thousands of years. Has similar qualities to DMT and related tryptamines. Very potent. Orally active in combination with an MAOI.", "effectsSummary": "The effect depends very much on the set and the setting. Blood pressure and pulse increase, pupils dilate. Detachment of the body from the mind and ego dissolution are common, near-death experiences also occur relatively often, especially when high doses are consumed. The perception of time changes greatly during intoxication. A few minutes can be perceived as very long and intense. In addition, different feelings such as fear, euphoria, etc. can be experienced within a short period of time. Consumers report immersion in very \"bizarre\" worlds in which connections between being, environment and matter arise. Physical perception can also be influenced, in that one feels weightless or thinks one is falling.\nWith 5-MeO-DMT, the potential effect is greater, but less optical than with DMT.", "dosageRemark": "MeO-DMT must be dosed very carefully, as even a few milligrams more can cause a very intense and unpleasant effect, which can result in psychological and mental problems lasting several weeks.", "generalRisks": "The risk associated with the use of 5-MeO-DMT is mainly psychological and depends on the personality structure of the user. The perceptual changes during a trip can be so intense that especially inexperienced users feel overwhelmed by the flood of impressions. The perception of sudden emotional outbursts can also be perceived as rather disturbing and overwhelming. At high doses, such psychological side effects can be felt for days to weeks. If the rules of the set and setting are not followed, there can be false reactions, loss of orientation, panic, paranoia and horror trips. Physical side effects include nausea, vomiting, increase in heart rate, slightly accelerated breathing, increased blood pressure, pupil dilation, increased salivation, tremors, restlessness, headaches and movement disorders.", "longtermRisks": "Permanent disturbances in self- and reality recognition are possible. The view of the world can be permanently called into question, which can make it difficult to cope with everyday life. Latent (hidden) psychoses can be triggered.", "saferUse": [ "Only consume when you feel good. If you are afraid of the strong effects, do not use. Do not use if you are afraid of the substance.", "Do not use 5-MeO-DMT alone! Take it in a safe atmosphere and together with experienced people you trust.", "Take 5-MeO-DMT while sitting or lying down, as physical perception and ability to move are impaired during intoxication.", "Dose carefully at first. If there is no effect, increase the dose the next time. Do not add more on the same day.", "The consumption of MAO-inhibiting foods such as matured cheese, smoked fish or meat, sauerkraut, tofu, chocolate etc. should be avoided before and after consumption.", "People with high blood pressure should not consume 5-MeO-DMT.", "A trip with 5-MeO-DMT should remain an exceptional experience. Make sure you take long breaks from using 5-MeO-DMT and talk to others about your experience so that it can be processed." ], "interactions": { "dangerous": [ "ΑMT", "MAOI", "PCP" ], "unsafe": [ "Substituted amphetamines", "Cocaine", "Dextromethorphan", "Tramadol" ], "uncertain": [ "2C-T-X", "2C-X", "Cannabis", "DOx", "MDMA", "Mescaline", "25x-NBOMe" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 3, "commonMin": 8, "strongMin": 15, "heavyMin": 25 }, "duration": { "onset": { "min": 1, "max": 10, "units": "minutes" }, "peak": { "min": 10, "max": 40, "units": "minutes" }, "offset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 2, "max": 3, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 6, "strongMin": 12, "heavyMin": 20 }, "duration": { "onset": { "min": 5, "max": 60, "units": "seconds" }, "comeup": { "min": 30, "max": 60, "units": "seconds" }, "peak": { "min": 5, "max": 15, "units": "minutes" }, "offset": { "min": 10, "max": 20, "units": "minutes" }, "total": { "min": 20, "max": 40, "units": "minutes" }, "afterglow": { "min": 15, "max": 60, "units": "minutes" } } } ] }, { "name": "5-MeO-MiPT", "commonNames": [ "5-MeO-MiPT", "Moxy" ], "url": "https://psychonautwiki.org/wiki/5-MeO-MiPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [], "categories": [ "psychedelic", "entactogen", "research-chemical", "common" ], "summary": "A potent, stimulating psychedelic tryptamine, sometimes compared to 5-MeO-DiPT. Has an unusually strong body component and weak visual effects. Often said to be very empathogenic.", "interactions": { "dangerous": [ "ΑMT", "MAOI", "PCP" ], "unsafe": [ "Substituted amphetamines", "Cocaine", "Dextromethorphan", "Tramadol" ], "uncertain": [ "2C-T-X", "2C-X", "Cannabis", "DOx", "MDMA", "Mescaline", "25x-NBOMe" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 7, "strongMin": 15, "heavyMin": 20 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 15, "heavyMin": 20 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } } ] }, { "name": "5F-AKB48", "commonNames": [ "5F-AKB48", "5F-APINACA" ], "url": "https://psychonautwiki.org/wiki/5F-AKB48", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "cannabinoids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "cannabinoid", "research-chemical", "tentative", "habit-forming" ], "summary": "A synthetic cannabanoid that is a Indazole. Produces subjective effects somehwat similar to that of Cannabis, yet with a very short duration. Analogue of STS-135, in which the core indole structure is subbed with an indazole base.", "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "2C-T-x", "2C-x", "5-MeO-xxT", "Substituted amphetamines", "ΑMT", "Cocaine", "DMT", "DOx", "LSD", "Mescaline", "Psilocybin mushrooms", "25x-NBOMe" ] }, "roas": [ { "name": "smoked", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 1, "strongMin": 2, "heavyMin": 4 }, "duration": { "onset": { "min": 0, "max": 20, "units": "minutes" }, "peak": { "min": 10, "max": 30, "units": "minutes" }, "offset": { "min": 5, "max": 10, "units": "minutes" }, "total": { "min": 30, "max": 60, "units": "minutes" }, "afterglow": { "min": 15, "max": 30, "units": "minutes" } } } ] }, { "name": "5F-PB-22", "commonNames": [], "url": "https://psychonautwiki.org/wiki/5F-PB-22", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "cannabinoids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "cannabinoid", "tentative", "research-chemical", "habit-forming" ], "summary": "Synthetic cannabinoid, agonist of the cannabinoid receptors which has a strong sedating aspect. Being a synthetic cannabinoid it has a very fast onset.", "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "2C-T-x", "2C-x", "5-MeO-xxT", "Substituted amphetamines", "ΑMT", "Cocaine", "DMT", "DOx", "LSD", "Mescaline", "Psilocybin mushrooms", "25x-NBOMe" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 3, "strongMin": 5, "heavyMin": 8 }, "duration": { "total": { "min": 2, "max": 3, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 3, "strongMin": 5, "heavyMin": 8 } } ] }, { "name": "6-APB", "commonNames": [ "6-APB", "Benzofury" ], "url": "https://psychonautwiki.org/wiki/6-APB", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "3-4 weeks", "zero": "6-8 weeks", "halfToleranceInHours": 588, "zeroToleranceInHours": 1176 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "psychedelic", "entactogen", "stimulant", "research-chemical", "habit-forming" ], "summary": "A stimulant, empathogen and analog of MDA. Typically more visual than MDMA or MDA, as well as having a much longer onset and duration. Users often report a slightly more psychedelic headspace as well. Commonly sold as an alternative to MDMA and MDA.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "SNRIs", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 15, "commonMin": 60, "strongMin": 90, "heavyMin": 120 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "comeup": { "min": 60, "max": 120, "units": "minutes" }, "peak": { "min": 3, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 7, "max": 10, "units": "hours" }, "afterglow": { "min": 6, "max": 48, "units": "hours" } } } ] }, { "name": "6-APDB", "commonNames": [ "6-APDB" ], "url": "https://psychonautwiki.org/wiki/6-APDB", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "21-30 days", "zero": "2-3 months", "halfToleranceInHours": 612, "zeroToleranceInHours": 1800 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "psychedelic", "research-chemical", "habit-forming" ], "summary": "A stimulant and entactogen related to MDMA and an analogue of MDA. Reported as being fairly psychedlic at higher doses. It is a triple monoamine reuptake inhibitor. Potent full agonist of serotonin 2B receptors.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "SNRIs", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 70, "strongMin": 100, "heavyMin": 130 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 6, "max": 8, "units": "hours" } } } ] }, { "name": "8-Chlorotheophylline", "commonNames": [], "url": "https://psychonautwiki.org/wiki/8-Chlorotheophylline", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant" ], "roas": [] }, { "name": "A-PHP", "commonNames": [ "α-PHP", "alpha-PHP", "PV7" ], "url": "https://psychonautwiki.org/wiki/A-PHP", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "highly addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 5, "strongMin": 15, "heavyMin": 25 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "peak": { "min": 20, "max": 45, "units": "minutes" }, "offset": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 2, "max": 5, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 10, "strongMin": 25, "heavyMin": 40 }, "duration": { "onset": { "min": 2, "max": 20, "units": "minutes" }, "peak": { "min": 1, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 5, "units": "hours" }, "total": { "min": 2, "max": 8, "units": "hours" }, "afterglow": { "min": 1, "max": 48, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 20 }, "duration": { "onset": { "min": 2, "max": 8, "units": "minutes" }, "peak": { "min": 30, "max": 90, "units": "minutes" }, "offset": { "min": 1, "max": 4, "units": "hours" }, "total": { "min": 2, "max": 5, "units": "hours" }, "afterglow": { "min": 1, "max": 8, "units": "hours" } } } ] }, { "name": "A-PVP", "commonNames": [ "α-PVP", "alpha-PVP", "Flakka", "Flak", "O-2387", "β-ketone-prolintane", "Prolintanone", "Gravel" ], "url": "https://psychonautwiki.org/wiki/A-PVP", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "highly addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 5, "strongMin": 15, "heavyMin": 25 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "peak": { "min": 20, "max": 45, "units": "minutes" }, "offset": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 2, "max": 5, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 10, "strongMin": 25, "heavyMin": 40 }, "duration": { "onset": { "min": 2, "max": 20, "units": "minutes" }, "peak": { "min": 1, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 5, "units": "hours" }, "total": { "min": 2, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 12, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 15, "heavyMin": 25 }, "duration": { "onset": { "min": 20, "max": 60, "units": "seconds" }, "peak": { "min": 3, "max": 6, "units": "minutes" }, "offset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 30, "max": 60, "units": "minutes" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } } ] }, { "name": "AB-FUBINACA", "commonNames": [ "Ab-fubi" ], "url": "https://psychonautwiki.org/wiki/AB-FUBINACA", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "cannabinoids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "cannabinoid", "research-chemical", "habit-forming", "tentative", "common" ], "summary": "Arguably the most common synthetic cannabinoid, AB-FUBINACA was originally developed by Pfizer as an analgesic, but has since abandoned for medical use. It has since found a following in the RC community, however it's extremely high potency and inclusion in synthetic blends makes it dangerous, and it has killed in overdose. Exercise caution.", "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "2C-T-x", "2C-x", "5-MeO-xxT", "Substituted amphetamines", "ΑMT", "Cocaine", "DMT", "DOx", "LSD", "Mescaline", "Psilocybin mushrooms", "25x-NBOMe" ] }, "roas": [ { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 2, "strongMin": 3, "heavyMin": 5 }, "duration": { "onset": { "min": 0, "max": 20, "units": "minutes" }, "peak": { "min": 30, "max": 60, "units": "minutes" }, "offset": { "min": 10, "max": 20, "units": "minutes" }, "total": { "min": 1, "max": 2, "units": "hours" }, "afterglow": { "min": 15, "max": 30, "units": "minutes" } } } ] }, { "name": "Acetylfentanyl", "commonNames": [ "Acetylfentanyl" ], "url": "https://psychonautwiki.org/wiki/Acetylfentanyl", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "extremely addictive with a high potential for abuse", "toxicities": [ "potentially fatal at heavy dosages", "potentially lethal when mixed with depressants like alcohol or benzodiazepines", "unintentionally spilling a very small amount of acetylfentanyl on one's skin could result in a fatal overdose." ], "categories": [ "opioid", "research-chemical", "habit-forming", "depressant" ], "summary": "Acetyl-Fentanyl is an opioid analgesic substance that is an analogue of Fentanyl. It's potency is roughly ~6.67 times that of Morphine. Making it ~15 times less potent than its parent compound Fentanyl.", "interactions": { "dangerous": [ "SNRIs", "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 2, "commonMin": 10, "strongMin": 15, "heavyMin": 20 }, "duration": { "onset": { "min": 7, "max": 10, "units": "minutes" }, "total": { "min": 3, "max": 4, "units": "hours" } } }, { "name": "sublingual", "dose": { "units": "mg", "lightMin": 2, "commonMin": 10, "strongMin": 15, "heavyMin": 20 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "total": { "min": 1, "max": 4, "units": "hours" } } } ] }, { "name": "Adrafinil", "commonNames": [ "Adrafinil", "Olmifon" ], "url": "https://psychonautwiki.org/wiki/Adrafinil", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzhydryl", "nootropic|nootropics" ], "addictionPotential": "not addictive with a low potential for abuse", "toxicities": [], "categories": [ "nootropic", "stimulant", "research-chemical", "habit-forming" ], "summary": "A prodrug to modafinil, this compound is often used to increase wakefulness and alertness. Due to hepatic metabolism it has a slower onset than modafinil and may cause liver damage in excess. Some users have reported acne as an adverse effect. Unregulated in the US.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 100, "commonMin": 250, "strongMin": 400, "heavyMin": 600 }, "duration": { "onset": { "min": 1, "max": 2, "units": "hours" }, "comeup": { "min": 45, "max": 60, "units": "minutes" }, "peak": { "min": 4.5, "max": 6, "units": "hours" }, "offset": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 6, "max": 12, "units": "hours" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "AL-LAD", "commonNames": [ "AL-LAD", "Aladdin" ], "url": "https://psychonautwiki.org/wiki/AL-LAD", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown", "extremely low toxicity" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "AL-LAD is a hallucinogenic drug, lysergamide and an analogue of LSD. It is reported as having some subtle experiential differences to LSD (such as increased visuals), and also appears to be slightly shorter lasting. AL-LAD doses are similar to those of LSD, depending on purity. Its availability on the Internet since 2013 has lead to strong popularity among the drug community.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 20, "commonMin": 100, "strongMin": 225, "heavyMin": 350 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2.5, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 7, "max": 10, "units": "hours" }, "afterglow": { "min": 2, "max": 18, "units": "hours" } } } ] }, { "name": "Alcohol", "commonNames": [ "Alcohol", "Booze", "Liquor", "Moonshine", "Sauce", "Juice", "Bevvy" ], "url": "https://psychonautwiki.org/wiki/Alcohol", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "GABA", "depressants" ], "addictionPotential": "extremely addictive with a high potential for abuse", "toxicities": [ "Death from ethanol consumption is possible when blood alcohol levels reach 0.4%" ], "categories": [ "depressant", "habit-forming", "common" ], "summary": "Alcohol is a CNS depressant that acts through the GABAₐ receptor, and is one of the most common strong psychoactives used by humans. It has a long history of use and its intoxicating effects are well-studied and documented. It remains legal in most parts of the world.", "effectsSummary": "Stimulation, relaxation, calming down, disinhibition, sociability, euphoria, reduction of the ability to react, overestimation of oneself and urge to talk, but also melancholy or irritability up to aggressiveness.\nAbsinthe (\"The Green Fairy\"), a high-proof spirit (usually 50 - 70 % by volume), contains the plant substance thujone. Together with the main active ingredient alcohol, thujone is said to have stimulating and mind-altering effects. In Europe, as in Switzerland, clear limits apply (max. 35 mg thujone per kg alcohol). Caution with chronic use! A thujone overdose manifests itself in seizures and epilepsy-like symptoms.", "dosageRemark": "Standard drinks such as 3 dl beer, 1 dl wine or 2 cl spirits contain about 12 g alcohol. The effect of alcohol is influenced by the amount consumed, the type of alcohol (sugary and/or carbonated), the period of consumption and individual factors (age, sex, weight). The blood alcohol concentration is measured in parts per thousand (‰). The higher the alcohol concentration in the blood, the stronger the effect of alcohol.", "generalRisks": "Small amounts of alcohol generally have a relaxing and exhilarating effect, a general feeling of well-being spreads, fears are reduced and sociability increases. The consumption of larger amounts can lead to balance and speech disorders, visual disturbances (double vision or tunnel vision), stomach pain, nausea to vomiting, headaches (hangover) due to dehydration, loss of control and blackouts. There is a risk of accidents due to overestimation of one's own abilities and reduced ability to react. High doses can lead to hypothermia or overheating, deep sleep and coma. Very high doses (blood alcohol concentration of 3-4‰) can be life-threatening.\nBinge drinking, i.e. the consumption of a large amount of alcohol in a very short time, causes the blood alcohol content to rise particularly quickly and strongly. This can quickly lead to alcohol poisoning. Consequences can be: comatose state, memory lapses (film tears), deactivation of important reflexes (danger of choking when vomiting, danger of freezing to death when cold) as well as epileptic seizures. There is also an increased risk of thrombosis, high or low blood pressure, respiratory depression and sudden cardiac death.", "longtermRisks": "Since alcohol is a cytotoxin, regular heavy consumption can have consequences such as damage to all bodily organs, deficiency symptoms, disorders of the nervous system, coordination of movement and memory functions, and even alcohol-induced dementia. Alcohol is a co-carcinogen, i.e. it significantly increases the carcinogenic effect of other substances (e.g. nicotine).\nAlcohol can produce a dependence with psychological and physical symptoms. Typical withdrawal symptoms are trembling, sweating, nausea and vomiting up to epileptic seizures. On a psychological level, irritability, anxiety disorders, depressive moods and hallucinations may occur. Tolerance develops with regular consumption.", "saferUse": [ "Do not consume alcohol out of boredom or when you feel bad.", "Drink alcohol with pleasure and take your time.", "Do not drink alcohol on an empty stomach.", "Avoid mixed consumption of different alcoholic drinks, drink water with it (e.g. a glass of water after each alcoholic drink).", "Be careful with mixed drinks (e.g. alcopops) or self-mixed drinks! With these sweet drinks you can hardly taste the alcohol, even though a 3-litre bottle contains about two schnapps. The danger of an unintentional overdose is high.", "In general, refrain from consuming alcohol if you consume other psychoactive substances; their effect is altered by the alcohol, or sometimes life-threatening side effects occur (e.g. alcohol and GHB = danger of suffocation!).", "If you drink, you don't drive. Use public transport, take a taxi or walk.", "Alcohol consumption during pregnancy is a risk for the foetus. Severe damage to the child can be the result.", "Follow the safe sex rules even when under the influence of alcohol." ], "interactions": { "dangerous": [ "Depressant", "Dissociatives", "Benzodiazepines", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Opioids", "Tramadol" ], "unsafe": [ "Cocaine", "MAOI", "PCP", "Antibiotics" ], "uncertain": [ "Stimulants", "Cannabis", "Substituted amphetamines", "ΑMT", "MDMA", "Nitrous", "SSRIs" ] }, "roas": [ { "name": "oral", "dose": { "units": "g", "lightMin": 10, "commonMin": 20, "strongMin": 30, "heavyMin": 40 }, "duration": { "onset": { "min": 2, "max": 5, "units": "minutes" }, "comeup": { "min": 15, "max": 45, "units": "minutes" }, "peak": { "min": 30, "max": 90, "units": "minutes" }, "offset": { "min": 45, "max": 120, "units": "minutes" }, "total": { "min": 1.5, "max": 5, "units": "hours" }, "afterglow": { "min": 6, "max": 48, "units": "hours" } } } ] }, { "name": "ALD-52", "commonNames": [ "ALD-52", "1-Acetyl-LSD", "1A-LSD", "1A-LAD", "Orange Sunshine" ], "url": "https://psychonautwiki.org/wiki/ALD-52", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown", "extremely low toxicity" ], "categories": [ "psychedelic", "research-chemical", "tentative" ], "summary": "ALD-52, or N-acetyl-LSD is a less common chemical analogue of LSD, first synthesised by Albert Hoffman. It was famously implicated in the 'Orange Sunshine' trial. A psychedelic lysergamide, this compound exhibits similar properties to LSD, and is thought to be a pro-drug for LSD.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 30, "commonMin": 100, "strongMin": 175, "heavyMin": 325 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "comeup": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 3, "max": 5, "units": "hours" }, "total": { "min": 8, "max": 14, "units": "hours" }, "afterglow": { "min": 4, "max": 24, "units": "hours" } } } ] }, { "name": "Allylescaline", "commonNames": [ "Allylescaline", "AL" ], "url": "https://psychonautwiki.org/wiki/Allylescaline", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "Mescaline analogue with a much lower dose, that seems to rely heavily on colours.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 15, "commonMin": 30, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 45, "max": 240, "units": "minutes" }, "total": { "min": 8, "max": 12, "units": "hours" } } } ] }, { "name": "Alpha-GPC", "commonNames": [ "Alpha-GPC", "Choline Alfoscerate", "L-Alpha Glycerylphosphorylcholine" ], "url": "https://psychonautwiki.org/wiki/Alpha-GPC", "isApproved": true, "tolerance": { "full": "after prolonged and repeated usage", "half": "7 days", "zero": "14 days", "halfToleranceInHours": 168, "zeroToleranceInHours": 336 }, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "extremely low toxicity" ], "categories": [ "nootropic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 300, "strongMin": 500, "heavyMin": 1000 }, "duration": { "onset": { "min": 45, "max": 75, "units": "minutes" }, "total": { "min": 4, "max": 8, "units": "hours" } } } ] }, { "name": "Alprazolam", "commonNames": [ "Xanax", "Alprazolam", "Ksalol" ], "url": "https://psychonautwiki.org/wiki/Alprazolam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7-14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "habit-forming", "common" ], "summary": "An extremely common benzodiazepine better known as Xanax, frequently prescribed for the treatment of anxiety and panic disorders. Alprazolam is short-lasting and primarily anxiolytic, though also possesses hypnotic properties. At high doses amnesia and loss of inhibition are common. Do not mix with other depressants.", "effectsSummary": "Anti-excitant and anti-anxiety, sedative, soporific and muscle relaxant. At high doses: slowing down, drowsiness, danger of memory lapses (\"film tear\").\nTaking benzodiazepines increases the effectiveness of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This triggers sedative (calming), hypnotic, anxiolytic (anxiety-relieving), anticonvulsant (anticonvulsant) and muscle-relaxing effects in the body. Benzodiazepines have a depressant effect on the central nervous system. The flow of information in the brain between the brain cells (neurons) is thereby reduced / disturbed and feelings and perceptions are dampened.\nThe breakdown of the individual active ingredients of benzodiazepines in the body is age-dependent and therefore varies from person to person.", "generalRisks": "There is little information available on risks, toxicity, side effects and long-term consequences. Therefore, the general information on benzodiazepines applies:\nWhen mixing with other downers (alcohol, GHB/GBL, heroin) there is a risk of respiratory paralysis!\nTaking benzodiazepines can cause numerous undesirable side effects. In addition, regular and long-term use carries a very high risk of physical and psychological dependence. Benzodiazepines should only be taken as prescribed by a doctor and only for a short period of time (max. 4-6 weeks). Longer-term use should be discussed with the treating specialist. The dosages and duration of action of the individual benzodiazepines differ considerably.\nSide effects of benzodiazepines may be as follows: Prolonged fatigue, gastrointestinal problems, impaired reactions, hypersensitivity reactions, headaches, dizziness, motor difficulties, visual disturbances, slowed breathing, muscle weakness, confusion, sexual dysfunction, aggression, outbursts of anger, restlessness, random movements, allergies, skin problems/rashes and speech and movement disorders. Some benzodiazepines can cause seizures in epileptics.", "longtermRisks": "Regular and long-term use can lead to psychological and physical dependence (very high dependence potential). Immediate discontinuation of the drug after prolonged use can lead to negative withdrawal symptoms (including dizziness, physical weakness, inner restlessness, tremors, sleep disturbances, headaches, sweating, nausea, hallucinations and depression).\nIn addition, seizures and memory disorders/loss and listlessness (hangover effects) can occur. In case of possible dependence, withdrawal should be discussed with a doctor beforehand and the withdrawal should be medically accompanied. It is extremely important that the dose is reduced gradually.", "saferUse": [ "If medicines are obtained on the black market or on the internet and not from a pharmacy/medical facility, the contents are unclear. Have the medicine tested for the exact ingredients in a drug check!", "Do not rely on dosage information from colleagues who regularly use benzodiazepines. Due to habituation or dependence, their doses can be much higher and fatal for new users.", "Blisters of counterfeits may look identical to the original packaging.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, opioids and/or other benzodiazepines is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!" ], "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.1, "commonMin": 0.5, "strongMin": 1.5, "heavyMin": 2 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 2, "max": 6, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "Amanita muscaria", "commonNames": [ "Fly agaric", "Fly amanita" ], "url": "https://psychonautwiki.org/wiki/Amanita_muscaria", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [], "roas": [] }, { "name": "Amphetamine", "commonNames": [ "Amphetamine", "Speed", "Adderall", "Pep" ], "url": "https://psychonautwiki.org/wiki/Amphetamine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "has high abuse potential and can cause psychological dependence with chronic use", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "habit-forming", "common" ], "summary": "A very popular CNS stimulant available on prescription and black markets. Recreational in high doses, producing mild euphoria and an abundance of energy. Popular in eastern europe and the US.", "effectsSummary": "The release of the endogenous neurotransmitters noradrenalin and dopamine produced by the use of amphetamine can cause a feeling of increased performance, an increase in self-esteem, an increase in body temperature, the suppression of tiredness, hunger and thirst, an increased willingness to take risks and a suppressed feeling of pain, and can lead to euphoria as well as an increased urge to talk (babble flash).", "dosageRemark": "Because of the varying purity (the amphetamine content varies from almost 0 % to almost 100 %!), dosing is difficult and the risk of overdose is high. Doses of more than 25 mg of pure amphetamine increase the negative effects. A dose of 50 mg/night should be the maximum, whether snorted or swallowed.", "generalRisks": "Tremors, restlessness, nausea, palpitations and cardiac arrhythmias, sleep disturbances, headaches, nervousness, irritability, loss of appetite, aggressive behaviour and, in combination with alcohol, danger of alcohol poisoning. At high doses: hallucinations, circulatory failure, strokes as well as kidney, liver and heart failure and states of deep unconsciousness. An often underestimated danger is the rise in body temperature, which can lead to dehydration of the body. In high doses, acute amphetamine psychosis can occur. Signs of this are hallucinations in the form of colour spots and with features of schizophrenia. The risk of such an acute mental disorder increases with consumption over several days and/or if high doses are taken and food intake and sleep are neglected over a longer period of time. Such an experience usually normalises after sufficient sleep. During and after coming down: extreme need for sleep, exhaustion, strong feeling of hunger,depressive mood, irritability, etc.", "longtermRisks": "There is a risk of addiction with psychological symptoms, especially if the use takes on a (performance-enhancing) function in everyday life (e.g. at work) or physical/psychological exhaustion is combated with amphetamine. Frequent use of amphetamine not infrequently leads to physical deficiency symptoms (e.g. calcium deficiency, which can lead to bone and tooth problems) and to psychological problems such as dejection or listlessness. Regular and high-dose use can lead to constant restlessness (but also persistent fatigue), sleep and circulatory disorders as well as anxiety disorders up to persistent amphetamine psychosis with paranoid delusions. In addition, high blood pressure, cardiac arrhythmias, weight loss, skin inflammations (\"speed pimples\"), stomach problems as well as liver and kidney damage and cramps are possible. Snorting damages the nasal mucous membranes and the nasal septum, swallowing damages the stomach mucous membranes. Chronic consumption also favours brain haemorrhages and strokes with sudden paralysis.", "saferUse": [ "Dose low. Think about how long you want to be awake before you take it! Do not suppress your need for sleep.", "The lowest-risk form of amphetamine use is to swallow it.", "Eat enough after consumption to prevent weight loss.", "Drink enough (non-alcoholic drinks).", "Take extra vitamin C and D and minerals (iron, calcium and magnesium) with frequent use.", "Follow the safer-sniffing rules when sniffing.", "Refrain from mixed consumption! Make sure to take breaks from consumption.", "Mentally ill persons, persons with high blood pressure, liver and kidney diseases, diabetics and pregnant women should refrain from using amphetamines.", "It is better not to wear headgear (danger of overheating!).", "Amphetamine pastes should always be well dried before consumption." ], "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 4, "commonMin": 15, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 1, "max": 5, "units": "minutes" }, "comeup": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1.5, "max": 3, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "intravenous", "dose": { "units": "mg", "lightMin": 4, "commonMin": 15, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 2, "max": 10, "units": "seconds" }, "comeup": { "min": 2, "max": 10, "units": "seconds" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 2.5, "commonMin": 10, "strongMin": 25, "heavyMin": 50 }, "duration": { "onset": { "min": 30, "max": 45, "units": "minutes" }, "comeup": { "min": 30, "max": 135, "units": "minutes" }, "peak": { "min": 2.5, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 6, "max": 8, "units": "hours" }, "afterglow": { "min": 3, "max": 6, "units": "hours" } } } ] }, { "name": "Anadenanthera peregrina", "commonNames": [ "Yopo", "Jopo", "Cohoba" ], "url": "https://psychonautwiki.org/wiki/Anadenanthera_peregrina", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [], "roas": [] }, { "name": "Aniracetam", "commonNames": [ "Aniracetam" ], "url": "https://psychonautwiki.org/wiki/Aniracetam", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "racetam", "nootropic" ], "addictionPotential": "non-addictive with a low potential for abuse", "toxicities": [], "categories": [ "nootropic", "research-chemical" ], "summary": "An anxiolytic nootropic which modulates the AMPA receptor. Significantly more potent than racetam. May have positive effects on memory and cognition. Little recreational value. Sold in Europe as a prescription drug, but not approved by the FDA in the US.", "interactions": { "dangerous": [ "MAOI" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 350, "commonMin": 1200, "strongMin": 1800, "heavyMin": 2400 }, "duration": { "onset": { "min": 45, "max": 90, "units": "minutes" }, "total": { "min": 3, "max": 5, "units": "hours" } } } ] }, { "name": "APICA", "commonNames": [ "APICA", "SDB-001", "2NE1" ], "url": "https://psychonautwiki.org/wiki/APICA", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "cannabinoids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "cannabinoid" ], "roas": [ { "name": "smoked", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 1.5, "strongMin": 2, "heavyMin": 4 }, "duration": { "onset": { "min": 0, "max": 20, "units": "seconds" }, "peak": { "min": 10, "max": 30, "units": "minutes" }, "offset": { "min": 5, "max": 10, "units": "minutes" }, "total": { "min": 30, "max": 60, "units": "minutes" }, "afterglow": { "min": 15, "max": 35, "units": "minutes" } } } ] }, { "name": "Armodafinil", "commonNames": [ "Armodafinil", "Nuvigil", "Waklert", "Artvigil", "R-Modawake", "Neoresotyl" ], "url": "https://psychonautwiki.org/wiki/Armodafinil", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzhydryl", "nootropic" ], "addictionPotential": "mildly addictive with a low potential for abuse", "toxicities": [ "The median lethal dose at which 50% of participants die (LD50) from either armodafinil or modafinil for human beings has never been reached" ], "categories": [ "eugeroic", "stimulant", "nootropic", "habit-forming" ], "summary": "The more potent of the two modafinil isomers, said to have a longer duration and lesser side effects. Sometimes prescribed for ADHD and daytime sleepiness.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "Hormonal birth control" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 100, "strongMin": 200, "heavyMin": 300 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 1, "max": 2.5, "units": "hours" }, "peak": { "min": 4, "max": 7, "units": "hours" }, "offset": { "min": 2, "max": 5, "units": "hours" }, "total": { "min": 8, "max": 15, "units": "hours" }, "afterglow": { "min": 2, "max": 12, "units": "hours" } } } ] }, { "name": "Atropa belladonna", "commonNames": [ "Belladonna", "Deadly nightshade" ], "url": "https://psychonautwiki.org/wiki/Atropa_belladonna", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "deliriant" ], "roas": [] }, { "name": "Ayahuasca", "commonNames": [ "Ayahuasca", "Aya", "Caapi", "Cipó", "Hoasca", "Vegetal", "Yagé", "Yajé", "Natem", "Shori" ], "url": "https://psychonautwiki.org/wiki/Ayahuasca", "isApproved": true, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "LD50 is around 50 times a regular dose" ], "categories": [ "psychedelic", "entactogen" ], "summary": "A concoction made of two or more plants that contain at least an MAOI and DMT, the combination of which allows the DMT to work orally. Typically associated to south american cultures. Also, sometimes approximated synthetically by taking an external MAOI with extracted DMT. Causes intense, spiritually orientated hallucinogenic experiences.", "roas": [ { "name": "oral", "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 5, "max": 10, "units": "hours" }, "afterglow": { "min": 1, "max": 8, "units": "hours" } } } ] }, { "name": "Baclofen", "commonNames": [ "Baclofen", "Lioresal" ], "url": "https://psychonautwiki.org/wiki/Baclofen", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "GABA" ], "addictionPotential": "moderately physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol, benzodiazepines or opioids" ], "categories": [ "depressant", "habit-forming" ], "summary": "Also known as Lioresal, Baclofen is a GABAb receptor agonist and central nervous system depressant used to treat spasticity, and holds promise as a treatment for alcoholism. It exhibits mild intoxicating effects similar to phenibut or pregabalin.", "interactions": { "dangerous": [ "Dissociatives", "Stimulants", "Alcohol", "Benzodiazepines", "Barbiturates", "GHB", "GBL", "Methaqualone", "Opioids", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 50, "heavyMin": 100 }, "duration": { "onset": { "min": 30, "max": 75, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "total": { "min": 8, "max": 14, "units": "hours" }, "afterglow": { "min": 6, "max": 12, "units": "hours" } } } ] }, { "name": "Benzydamine", "commonNames": [ "Benzydamine", "Tantum Verde" ], "url": "https://psychonautwiki.org/wiki/Benzydamine", "isApproved": true, "crossTolerances": [], "toxicities": [ "toxic dose is unknown" ], "categories": [ "deliriant", "stimulant", "tentative" ], "summary": "NSAID with local anesthetic and analgesic properties, similar to ibuprofen or naproxen. Sometimes abused in overdose with reported delirant and stimulant effects.", "roas": [ { "name": "oral", "dose": { "units": "g", "lightMin": 0.25, "commonMin": 1, "strongMin": 1.5, "heavyMin": 2 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 3, "max": 6, "units": "hours" }, "offset": { "min": 3, "max": 8, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" } } } ] }, { "name": "Beta-Carboline", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Beta-Carboline", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [], "roas": [] }, { "name": "Bromantane", "commonNames": [ "Bromantane", "Bromantan", "Ladasten" ], "url": "https://psychonautwiki.org/wiki/Bromantane", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant", "nootropic", "depressant", "research-chemical" ], "summary": "An unusual stimulant and anxiolytic drug with dopamine and serotonin reuptake inhibition properties. Infamously used as a doping agent in the 1996 Olympics. There are some concerns it may exacerbate the underlying causes of Alzheimer's disease.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 50, "strongMin": 100, "heavyMin": 200 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" } }, "bioavailability": { "max": 42 } } ] }, { "name": "Bromazepam", "commonNames": [ "Bromazepam", "Brozam", "Lectopam", "Lexomil", "Lexotan", "Lexilium", "Lexaurin", "Brazepam", "Rekotnil", "Bromaze", "Somalium", "Lexatin", "Calmepam", "Zepam", "Lexotanil" ], "url": "https://psychonautwiki.org/wiki/Bromazepam", "isApproved": false, "crossTolerances": [], "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "benzodiazepine", "habit-forming", "depressant" ], "summary": "A benzodiazepine drug with a medium-long duration, developed by Roche in the 1960s. Has primarily anxiolytic properties. May cause lowered inhibitions and amnesia in high doses.", "interactions": { "dangerous": [ "Depressant", "Dissociatives", "Stimulants" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 6, "strongMin": 9, "heavyMin": 12 }, "duration": { "onset": { "min": 14, "max": 15, "units": "minutes" }, "comeup": { "min": 15, "max": 120, "units": "minutes" }, "peak": { "min": 2, "max": 12, "units": "hours" }, "offset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 6, "max": 15, "units": "hours" }, "afterglow": { "min": 12, "max": 22, "units": "hours" } } } ] }, { "name": "Bromazolam", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Bromazolam", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [ "depressant", "benzodiazepine", "research-chemical", "tentative", "habit-forming" ], "summary": "A rather novel Benzodiazepine that is structurally quite close to Alprazolam.", "roas": [] }, { "name": "Bromo-DragonFLY", "commonNames": [ "Bromo-DragonFLY", "DOB-DragonFLY", "B-DFLY", "Dragonfly" ], "url": "https://psychonautwiki.org/wiki/Bromo-DragonFLY", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "6 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "extreme vasoconstrictive effects", "one can easily overdose if this substance is not measured correctly", "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A psychedelic phenethylamine and benzofuran that is very potent and has a long duration. Was briefly sold as \"2C-B-FLY\" in 2005/6 and has lead to multiple deaths.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 75, "commonMin": 300, "strongMin": 500, "heavyMin": 750 }, "duration": { "onset": { "min": 2, "max": 7, "units": "hours" }, "comeup": { "min": 3, "max": 6, "units": "hours" }, "peak": { "min": 6, "max": 12, "units": "hours" }, "offset": { "min": 3, "max": 8, "units": "hours" }, "total": { "min": 1, "max": 4, "units": "days" }, "afterglow": { "min": 12, "max": 36, "units": "hours" } } } ] }, { "name": "Bufotenin", "commonNames": [ "Bufotenin", "5-HO-DMT" ], "url": "https://psychonautwiki.org/wiki/Bufotenin", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "1 hour", "zero": "2 hours", "halfToleranceInHours": 1, "zeroToleranceInHours": 2 }, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic" ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "smoked", "dose": { "units": "mg", "lightMin": 2, "commonMin": 20, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 15, "max": 60, "units": "seconds" }, "peak": { "min": 1, "max": 5, "units": "minutes" }, "offset": { "min": 5, "max": 10, "units": "minutes" }, "total": { "min": 15, "max": 90, "units": "minutes" }, "afterglow": { "min": 10, "max": 60, "units": "minutes" } } } ] }, { "name": "Buprenorphine", "commonNames": [ "Buprenex", "Subutex", "Butrans", "Cizdol", "Addnok", "Transtec" ], "url": "https://psychonautwiki.org/wiki/Buprenorphine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "low toxicity" ], "categories": [ "opioid", "habit-forming", "depressant" ], "summary": "A semi-synthetic opioid analgesic also known as subutex. Often administered as Butrans patches, or in combination with Naloxone as Suboxone, a heroin replacement therapy drug. Will cause withdrawals if you have an opioid tolerance and don't wait long enough (typically around 48 hours) before taking this.", "effectsSummary": "Like all opiates, buprenorphine has analgesic and cough-irritant effects. However, its euphoric and sedative properties are less pronounced than those of other opioids, which is why it is also used for substitution treatment. Buprenorphine is a partial agonist. This means that, for safety reasons, only a submaximal effect is elicited. After a certain dose, a saturation effect (ceiling effect) occurs, which prevents a further increase in the effect. This makes the active ingredient so relevant for substitution treatments, as withdrawal symptoms can be alleviated and overdoses avoided.", "dosageRemark": "From 16 mg, the saturation effect (ceiling effect) takes effect and no more effect enhancement is felt.\nWhen consuming for the first time, low doses should be used, as the risk of respiratory arrest is increased.", "generalRisks": "The side effects are less pronounced than with other opioids. Nevertheless, fatigue, constipation, drowsiness, sweating, nausea, vomiting, insomnia and irritability may occur. Buprenorphine has a lower risk of respiratory depression, which is why it is considered comparatively safe.\nOverdoses with buprenorphine are difficult to treat with the opioid antagonist naloxone due to its high binding to the μ-opioid receptor. Therefore, agents from the group of respiratory stimulants (such as doxapram) are used.", "longtermRisks": "Unlike other opioids, the active ingredient floods on slowly, which is why the risk of dependence is considered lower.", "saferUse": [ "Opioids are highly effective drugs that should only be used for a limited time and at best under medical supervision.", "Start with a low dose and wait for the effect and tolerance before adding more. Do not exceed the maximum daily dose.", "If you inject opioids, dose even more carefully, as the range between desired effect (rush) and dangerous overdose is even more difficult to assess. Avoid injecting fentanyl; the risk of overdose is particularly high. Always use new (clean and sterile) injection material! Never exchange syringes, filters, water, disinfection swabs to avoid transmission of hepatitis and HIV.", "Do not rely on dosage information from colleagues who regularly use opioids. Due to habituation or dependence, their doses are much higher and can be fatal for new users.", "Take longer breaks (at least several days) between consumption.", "After a period of abstinence, take a much lower dose! The usual dose before the abstinence phase can otherwise quickly have life-threatening consequences.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, benzodiazepines and/or other opioids is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!", "Refrain from citrus fruits (especially grapefruit) before or during consumption. The combination can lead to an increase in the effect of the opiate and/or to respiratory depression." ], "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 0.2, "commonMin": 0.4, "strongMin": 0.8, "heavyMin": 1.5 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 4, "max": 8, "units": "hours" }, "total": { "min": 8, "max": 14, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "days" } } }, { "name": "sublingual", "dose": { "units": "mg", "lightMin": 0.3, "commonMin": 2, "strongMin": 4, "heavyMin": 8 }, "duration": { "onset": { "min": 40, "max": 80, "units": "minutes" }, "peak": { "min": 1.5, "max": 2, "units": "hours" }, "total": { "min": 18, "max": 24, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "days" } } } ] }, { "name": "Bupropion", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Bupropion", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant", "habit-forming" ], "summary": "A frequently prescribed atypical antidepressant. Occasionally prescribed as an aid to smoking cessation. May lower seizure threshold in predisposed individuals. Poorly understood mechanism of action, probably an NDRI. Avoid combination with other drugs.", "interactions": { "dangerous": [ "Tramadol", "Tapentadol", "Dextropropoxyphene", "lithium", "Dextromethorphan", "ΑMT", "MAOI" ], "unsafe": [ "Stimulants", "Cannabis", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 75, "commonMin": 125, "strongMin": 225, "heavyMin": 325 }, "duration": { "onset": { "min": 40, "max": 60, "units": "minutes" }, "total": { "min": 8, "max": 12, "units": "hours" } } } ] }, { "name": "Buspirone", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Buspirone", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [ "psychedelic" ], "roas": [ { "name": "oral", "dose": { "units": "mg" } }, { "name": "sublingual", "dose": { "units": "mg" } } ] }, { "name": "Butylone", "commonNames": [ "Butylone", "bk-MBDB", "B1" ], "url": "https://psychonautwiki.org/wiki/Butylone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "psychedelic", "research-chemical", "habit-forming" ], "summary": "Empathogen and stimulant of the cathinone class.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 80, "strongMin": 125, "heavyMin": 225 }, "duration": { "onset": { "min": 15, "max": 60, "units": "minutes" }, "peak": { "min": 60, "max": 120, "units": "minutes" }, "offset": { "min": 60, "max": 120, "units": "minutes" }, "total": { "min": 3, "max": 5, "units": "hours" }, "afterglow": { "min": 4, "max": 12, "units": "hours" } } } ] }, { "name": "Caffeine", "commonNames": [ "Caffeine" ], "url": "https://psychonautwiki.org/wiki/Caffeine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [], "addictionPotential": "produces dependence with chronic use and has a low abuse potential", "toxicities": [ "The LD50 of caffeine in humans is dependent on individual sensitivity, but is estimated to be about 150 to 200 milligrams per kilogram of body mass or roughly 80 to 100 cups of coffee for an average adult" ], "categories": [ "stimulant", "habit-forming", "nootropic", "common" ], "summary": "Caffeine is a a CNS stimulant, and also the most widely used psychoactive substance in the world. It is legal and unregulated in most parts of the world, and is found in many commonly sold products. It has a good safety profile, though regular heavy use can cause physical dependence and contribute to certain medical conditions.", "effectsSummary": "Caffeine makes you awake, speeds up the heartbeat and temporarily increases mental performance. In higher doses (approx. 300 - 600 mg = approx. 8 cups of coffee) it produces euphoria.", "generalRisks": "Caffeine dehydrates the body (dehydration). At very high doses: sweating, fluttering of the heart, urge to urinate, cardiac arrhythmia, strong disturbances of perception, trembling, nervousness and sleep disturbances.", "longtermRisks": "With long-term, regular and high-dose caffeine consumption (also with coffee or energy drinks), there is a risk of dependence with physical symptoms. Possible withdrawal symptoms: headaches, nervousness, fatigue, vomiting and even movement and concentration disorders. The acidity of coffee also promotes the formation of stomach ulcers in the long term. Continuous consumption of caffeine with painkillers can lead to severe kidney damage with life-threatening complications.", "saferUse": [ "Do not consume pure caffeine, rather drink coffee or guarana. In addition to caffeine, energy drinks also contain a lot of sugar.", "Pure (synthetic) caffeine in powder form is often mixed with amphetamine and sold as speed." ], "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "DOx", "25x-NBOMe", "ΑMT", "PCP", "Substituted amphetamines", "MDMA", "Cocaine" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 2.5, "commonMin": 25, "strongMin": 40, "heavyMin": 80 }, "duration": { "onset": { "min": 0.5, "max": 2, "units": "minutes" }, "comeup": { "min": 0.5, "max": 2, "units": "minutes" }, "peak": { "min": 0.5, "max": 1, "units": "hours" }, "offset": { "min": 6, "max": 10, "units": "hours" }, "total": { "min": 1, "max": 2.5, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 50, "strongMin": 150, "heavyMin": 500 }, "duration": { "onset": { "min": 5, "max": 10, "units": "minutes" }, "comeup": { "min": 10, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 6, "max": 10, "units": "hours" }, "total": { "min": 2, "max": 5, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "Cannabidiol", "commonNames": [ "Cannabidiol", "CBD", "Epidiolex" ], "url": "https://psychonautwiki.org/wiki/Cannabidiol", "isApproved": true, "crossTolerances": [], "addictionPotential": "low abuse potential", "toxicities": [ "well-tolerated and shows little to no toxicity" ], "categories": [ "cannabinoid" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 15, "strongMin": 30, "heavyMin": 60 }, "duration": { "comeup": { "min": 15, "max": 30, "units": "minutes" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 1.5, "max": 4, "units": "hours" } } } ] }, { "name": "Cannabis", "commonNames": [ "Cannabis", "Marijuana", "Weed", "Pot", "Mary Jane", "Grass", "Herb", "Green", "Bud", "Tree" ], "url": "https://psychonautwiki.org/wiki/Cannabis", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "1 - 2 weeks", "zero": "2 - 3 weeks", "halfToleranceInHours": 252, "zeroToleranceInHours": 420 }, "crossTolerances": [ "cannabinoids" ], "addictionPotential": "moderately habit-forming", "toxicities": [], "categories": [ "habit-forming", "common" ], "summary": "A common and widely used psychoactive plant, which is beginning to enjoy legal status for medical and even recreational use in some parts of the world. Usually smoked or eaten, primary effects are relaxation and an affinity towards food - a state described as being 'stoned.'", "effectsSummary": "The most important of a total of 400 active ingredients are THC (tetrahydrocannabinol) and CBD (cannabidiol), with THC being responsible for the majority of the psychoactive effects felt. CBD also has analgesic, sedative and narcotic effects.\nThe main cannabis active substances THC and CBD dock in the body to the cannabinoid receptors CB1 and CB2. This activates the body's own messenger substance endocannabinoid. This has a relaxing, appetite-stimulating, calming and pain-relieving effect. Feelings are intensified, serenity and/or groundless cheerfulness set in. The experience of time is changed, usually slowed down. In high doses and CBD-free varieties, cannabis can have hallucinogenic effects. Since it is usually consumed together with tobacco, the joint-typical effect is an interaction between cannabis and tobacco. This usually leads to an intensification and prolongation of the effect, as tobacco inhibits the degradation of endocannabinoids. ", "dosageRemark": "The main active ingredient content and the ratio of THC to CBD differ greatly depending on the product. Therefore, the dosage is difficult to determine. Hashish contains on average more THC and mostly CBD. Outdoor weed varieties contain less THC and less CBD, while indoor weed varieties contain mainly THC and rarely CBD.\nCYP2C9 genotype affects THC sensitivity significantly: Subjects with the *3/*3 genotype had 3-fold higher THC levels in their blood than subjects with the *1/*1 genotype. Those subjects with one copy of each gene (*1/*3) had intermediate THC levels that were about 2-fold higher than subjects with *1/*1.", "generalRisks": "Increase in heart rate and pulse rate, reddening of the eyes, dry mouth, excessive feeling of hunger (binge eating), dizziness, nausea and vomiting, general impairment of the ability to concentrate and remember during intoxication, as well as unpleasant intensification of feelings or introversion, drifting into one's own world of thoughts. At high doses and varieties with little CBD, circulatory problems up to circulatory collapse, in the worst case paranoia and depressive moods may occur.\nWhen consuming cannabis products, the dosage is more difficult to estimate, making the risks and side effects more unpredictable.", "longtermRisks": "With frequent and regular use, there is a risk of psychological dependence. Symptoms of mild physical dependence may also manifest themselves; in the case of sudden abstinence, sweating, hot/cold shivers, loss of appetite and difficulty falling asleep as well as irritability are possible. In the case of chronic use, there is a danger of loss of reality; latent psychoses can be triggered. In addition, long-term impairment of short-term memory and the ability to motivate oneself is possible.\nSmoking, especially when mixed with tobacco, increases susceptibility to respiratory problems (bronchitis, tracheitis, pneumonia, etc.) when consumed chronically. Due to the deeper inhalation as well as poorer filtering methods (such as cardboard filters), joints are more harmful to the lungs than cigarettes.", "saferUse": [ "Currently, there are many misdeclared and stretched cannabis products in circulation. Therefore, if possible, use cannabis drug checking and follow the safer use instructions for synthetic cannabinoids.", "When using new cannabis products for the first time, try a small amount first to see if you notice any suspicious effects (e.g. rapid onset of effects, unusually strong effects, etc.).", "Cannabis products temporarily affect the ability to remember and concentrate. Consumption at work and at school is therefore not advisable.", "When smoking, make sure you use good filtering methods (activated carbon filters) or use a vaporizer.", "Since cannabis products are used mixed with tobacco, there is also a tobacco addiction with daily use. There are some tobacco substitutes such as damiana or coltsfoot that you can use instead of tobacco.", "Eating or drinking cannabis products is easy on the lungs, but the effects are stronger and more unpredictable than smoking. The risk of very high and highly psychoactive doses is high. Carefully approach the right dose, don't add more right away!", "Since the brain is developing until the age of 25, you should not use regularly until that age. You are more likely to be exposed to side effects and long-term risks from cannabis use.", "Do not consume if you are not well, latent psychoses could be triggered.", "In the case of mental illness, cannabis can aggravate the course of the disease or lead to relapses.", "Cannabis use should be avoided in cases of lung disease and existing heart conditions or heart disease." ], "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "2C-T-x", "2C-x", "5-MeO-xxT", "Substituted amphetamines", "ΑMT", "Cocaine", "DMT", "DOx", "LSD", "Mescaline", "Psilocybin mushrooms", "25x-NBOMe" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 25 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 4, "max": 6, "units": "hours" }, "total": { "min": 4, "max": 10, "units": "hours" }, "afterglow": { "min": 6, "max": 12, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 0.4, "commonMin": 2, "strongMin": 4, "heavyMin": 10 }, "duration": { "onset": { "min": 0.1, "max": 10, "units": "minutes" }, "comeup": { "min": 5, "max": 10, "units": "minutes" }, "peak": { "min": 15, "max": 45, "units": "minutes" }, "offset": { "min": 3, "max": 4, "units": "hours" }, "total": { "min": 2.3, "max": 5, "units": "hours" }, "afterglow": { "min": 45, "max": 180, "units": "minutes" } } }, { "name": "sublingual", "duration": { "onset": { "min": 1, "max": 10, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 30, "max": 60, "units": "minutes" }, "offset": { "min": 4, "max": 6, "units": "hours" }, "total": { "min": 3, "max": 7, "units": "hours" } } } ] }, { "name": "Carisoprodol", "commonNames": [ "Carisoprodol", "Soma" ], "url": "https://psychonautwiki.org/wiki/Carisoprodol", "isApproved": true, "crossTolerances": [], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "moderate toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "habit-forming" ], "summary": "A skeletal muscle relaxant drug also known as Soma, carisoprodol has limited recreational value, however its main metabolite meprobamate has some moderate tranquilising properties. Sometimes found in concoctions with codeine or caffeine.", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 325, "strongMin": 500, "heavyMin": 750 }, "duration": { "onset": { "min": 15, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 5, "units": "hours" }, "afterglow": { "min": 1, "max": 12, "units": "hours" } } } ] }, { "name": "Changa", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Changa", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "psychedelic", "tentative" ], "summary": "Changa is the name given to a smoking blend of caapi or other MAOI containing plants with an infusion of extracted DMT. Changa often contains other milder psychoactive herbs as well. The maoi action results in a longer and more intense trip (see Ayahuasca) NOTE: There is no standardized recipe or concentration of infused DMT, therefor dosage and potency will vary per batch.", "interactions": { "dangerous": [ "SNRIs", "Stimulants", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [], "uncertain": [] }, "roas": [] }, { "name": "Choline bitartrate", "commonNames": [ "Choline" ], "url": "https://psychonautwiki.org/wiki/Choline_bitartrate", "isApproved": true, "tolerance": { "full": "after prolonged and repeated usage", "half": "7 days", "zero": "14 days", "halfToleranceInHours": 168, "zeroToleranceInHours": 336 }, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "extremely low toxicity" ], "categories": [ "nootropic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 250, "strongMin": 1000, "heavyMin": 2000 }, "duration": { "onset": { "min": 45, "max": 75, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 2, "max": 8, "units": "hours" } } } ] }, { "name": "Cinolazepam", "commonNames": [ "Cinolazepam", "Gerodorm" ], "url": "https://psychonautwiki.org/wiki/Cinolazepam", "isApproved": false, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "habit-forming" ], "summary": "A benzodiazepine derivative drug with anxiolytic effects but mainly hypnotic effects. It is extremely effective for sleep aid but has mild euphoria compared to other benzos", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 40, "strongMin": 80, "heavyMin": 200 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 6, "units": "hours" }, "afterglow": { "min": 12, "max": 24, "units": "hours" } } } ] }, { "name": "Citicoline", "commonNames": [ "Citicoline" ], "url": "https://psychonautwiki.org/wiki/Citicoline", "isApproved": true, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "extremely low toxicity" ], "categories": [ "nootropic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 250, "strongMin": 1000, "heavyMin": 2000 }, "duration": { "onset": { "min": 1, "max": 2, "units": "hours" }, "comeup": { "min": 2, "max": 3, "units": "hours" }, "peak": { "min": 2.5, "max": 3.5, "units": "hours" }, "offset": { "min": 30, "max": 40, "units": "hours" }, "total": { "min": 58, "max": 74, "units": "hours" }, "afterglow": { "min": 40, "max": 60, "units": "hours" } } } ] }, { "name": "Clonazepam", "commonNames": [ "Clonazepam", "Klonopin", "K-Pins", "Rivotril" ], "url": "https://psychonautwiki.org/wiki/Clonazepam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "habit-forming", "common" ], "summary": "A medium-length common prescription benzodiazepine, often used to treat panic attacks because of its relatively fast sublingual onset. Primarily anxiolytic, but also possessing of other benzo traits.", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.1, "commonMin": 0.5, "strongMin": 1, "heavyMin": 2 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 8, "max": 48, "units": "hours" } } } ] }, { "name": "Clonazolam", "commonNames": [ "Clonazolam", "Clonitrazolam" ], "url": "https://psychonautwiki.org/wiki/Clonazolam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal" ], "categories": [ "depressant", "benzodiazepine", "research-chemical", "habit-forming", "common" ], "summary": "A long lasting benzodiazepine with heavily hypnotic effects. The safety profile is not well established, and there have been reports that people taking it three days in a row have had a seizure. Most comparable to Triazolam, but with a much longer half-life.", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 50, "commonMin": 200, "strongMin": 400, "heavyMin": 1 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "total": { "min": 6, "max": 10, "units": "hours" } } } ] }, { "name": "Clonidine", "commonNames": [ "Catapres", "Catapres-TTS", "Kapvay", "Nexiclon XR" ], "url": "https://psychonautwiki.org/wiki/Clonidine", "isApproved": true, "crossTolerances": [], "addictionPotential": "not addictive and has a low potential for abuse", "toxicities": [], "categories": [ "depressant", "common" ], "summary": "Is a medication that is used to treat high blood pressure, anxiety, withdrawal (Typically from Alcohol, Opioids, Smoking) and many other uses.", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 25, "commonMin": 75, "strongMin": 100, "heavyMin": 300 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 6, "max": 8, "units": "hours" }, "total": { "min": 6, "max": 8, "units": "hours" } } } ] }, { "name": "Cocaine", "commonNames": [ "Cocaine", "Coke", "Coca", "Crack", "Blow", "Girl", "White", "Snow", "Nose Candy", "Chari" ], "url": "https://psychonautwiki.org/wiki/Cocaine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "highly addictive with a high potential for abuse", "toxicities": [ "individuals have died from as little as 30 mg applied to mucous membranes, whereas addicts may tolerate up to 5 grams daily" ], "categories": [ "stimulant", "habit-forming", "common" ], "summary": "A highly popular, short acting CNS stimulant that works by blocking the reuptake of dopamine, serotonin, and norepinephrine. It is known to increase euphoria, confidence, sex-drive, focus, body temperature, and heart rate. Cocaine can cause severe vasoconstriction and is known to be cardiotoxic and have a high potential for compulsive redosing and addiction.", "effectsSummary": "The increased release and additional reuptake inhibition of the body's own neurotransmitters dopamine and noradrenaline lead to the suppression of tiredness, hunger and thirst, euphoria, feelings of increased performance, greatly increased self-confidence, urge to move, restlessness, talkativeness, elimination of inhibitions and fears, suppressed sense of pain, as well as increased willingness to take risks.\n\nCoca leaves are known as \"Mate de Coca\" or dried leaves. These dried leaves contain about 0.5 to 2.5 % alkaloids, of which up to three quarters consist of cocaine. The leaves are chewed or drunk as tea. However, a psychoactive effect only occurs when they are taken in combination with a basic substance (e.g. lime or plant ash). This combination activates a hydrolysis, resulting in the alkaloid ecgonine. Ecgonine can be absorbed by the body and a slightly stimulating effect sets in. In contrast to cocaine, ecgonine has no dependence potential. If coca leaves are chewed without alkaline additives, they only have a numbing effect on the tongue. Coca leaves are used in South America mainly for medicinal purposes, e.g. to combat nausea or altitude sickness.", "generalRisks": "Sleep disturbances, irritability, aggressiveness, exaggerated egocentrism up to \"megalomania\", decrease in critical and judgemental ability, anxiety and delusions, depression, memory/concentration disorders, shortness of breath, hyperactivity, nervous twitching, muscle cramps and tremors, high stress on the cardiovascular system due to constriction of the blood vessels, increase in heart rate, increased blood pressure and hypertensive crises. In extreme cases, overdose can lead to a heart attack or stroke.\nWhen the effect wears off: exhaustion, depressive moods, irritability, feelings of anxiety and a strong urge to take the drug again (\"craving\").", "longtermRisks": "Chronic use: psychological dependence. \"Craving\" (irresistible and uncontrollable desire to consume) can be triggered quickly by so-called trigger effects (situations, memories, people, etc., which are associated with consumption). Other long-term risks are anxiety disorders, personality changes such as reduced empathy, emotional coldness, exaggerated mistrust, depression, mental disorders with paranoid delusions and hallucinations, alteration of thought processes, permanent disturbances of short-term memory and intellectual abilities. Nerve damage, nervous twitching, seizures, alteration of movement patterns, damage to: Heart, liver, kidneys, lungs, skin, blood vessels and teeth. General weakening of the immune system, in extreme cases with necrosis (death of skin cells), liver damage due to the breakdown of toxins and the risk of kidney damage due to extender.\nChronic inflammation and damage to the nasal mucous membranes and nasal septum, which is difficult to heal. When smoking freebase and crack, damage to the lungs and respiratory tract is possible due to the deposition of combustion residues (ash residues). When injecting or smoking (freebase), the phenomenon of \"dermatozoan madness\" (the idea that there are worms or insects under the skin, perception of a tingling sensation under the skin) is known. Colloquially also called \"cocaine worms/bugs\"). This delusion leads to excessive scratching of the arms and/or legs, up to open injuries, which can lead to abscesses if hygiene is poor.", "saferUse": [ "Attention, very high risk of psychological dependence! Take breaks from using, especially if it is difficult for you.", "Keep the dosage low and avoid frequent refilling!", "Drink enough soft drinks and take breaks in the fresh air.", "Eat healthy before and after consumption and do not consume on an empty stomach.", "Follow the safer sniffing and safer sex rules.", "Snorting is the lowest-risk form of use. Smoking crack and freebase as well as injecting increase the risks (no syringe exchange!).", "People with pre-existing cardiovascular conditions, asthma, liver disease, hyperthyroidism and pregnant women should not use cocaine.", "Do not combine cocaine with other stimulants or drugs that increase blood pressure.", "Do not use cocaine if you have used ecstasy; this will cancel out the ecstasy effect.", "Do not mix cocaine with alcohol; the mixture makes you aggressive and you risk alcohol poisoning." ], "interactions": { "dangerous": [ "ΑMT", "Opioids", "Tramadol", "MAOI" ], "unsafe": [ "DOx", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "Dextromethorphan", "PCP", "Alcohol" ], "uncertain": [ "Psilocybin mushrooms", "LSD", "DMT", "Mescaline", "2C-x", "Cannabis", "Ketamine", "Methoxetamine", "Substituted amphetamines", "MDMA", "Caffeine", "GHB", "GBL" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 30, "strongMin": 60, "heavyMin": 90 }, "duration": { "onset": { "min": 1, "max": 10, "units": "minutes" }, "comeup": { "min": 5, "max": 15, "units": "minutes" }, "peak": { "min": 15, "max": 30, "units": "minutes" }, "offset": { "min": 10, "max": 30, "units": "minutes" }, "total": { "min": 10, "max": 90, "units": "minutes" } } }, { "name": "smoked", "duration": { "onset": { "min": 3, "max": 5, "units": "seconds" }, "comeup": { "min": 1, "max": 2, "units": "minutes" }, "peak": { "min": 2, "max": 10, "units": "minutes" }, "offset": { "min": 1, "max": 5, "units": "minutes" }, "total": { "min": 5, "max": 15, "units": "minutes" } } } ] }, { "name": "Cocoa", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Cocoa", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [], "roas": [] }, { "name": "Codeine", "commonNames": [ "Codeine", "Lean", "Purple Drank", "Syrup" ], "url": "https://psychonautwiki.org/wiki/Codeine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or benzodiazepines" ], "categories": [ "opioid", "habit-forming", "depressant", "common" ], "summary": "Codeine is a weaker opioid used to treat mild to moderate pain and to relieve cough. In many countries it is available over the counter in combination with paracetamol, which can easily be extracted to retrieve near-pure codeine. For this reason, it is used widely as a recreational opioid. It is metabolised into morphine in the body at a rate of 5% mg for mg.", "effectsSummary": "Codeine is converted into morphine in the body. Taking it has a pain-relieving, cough-irritating, calming, euphoric and aphrodisiac effect. An increase in self-confidence is also possible. It should be remembered, however, that the effect varies greatly depending on the individual metabolism. While some people react very sensitively to codeine, others feel no psychoactive effect at all.", "dosageRemark": "An increase in effect at high doses is rarely seen, as the body can only absorb limited amounts of codeine.", "generalRisks": "Dry mouth, headache, nausea, vomiting, loss of appetite, itching, constipation, difficulty in urinating, tiredness/sleepiness, decrease in respiratory rate up to a life-threatening respiratory depression. In men, erectile dysfunction may also occur.\nThere is a risk of psychological and physical dependence. In the case of chronic use, tolerance may develop, so that the dose must be progressively increased to achieve the desired effect. When discontinuing codeine after a phase of continuous use, withdrawal symptoms such as restlessness, stomach and/or leg cramps, cold shivers, trembling, profuse sweating and muscle spasms may appear. Due to the high dependence potential, withdrawal can be as painful and long-lasting as heroin withdrawal (!).", "longtermRisks": "In men, there may be a reduction in sexual desire (libido). In women, menstruation may be absent or irregular and sexual desire may be reduced. Other long-term risks include allergic reactions, sleep disturbances and dizziness. The dependence potential of codeine is lower than that of other opiates, but should still not be underestimated!", "saferUse": [ "Do not use codeine with other depressant substances such as alcohol, cannabis, sleeping pills, MAO inhibitors (such as antidepressants) or GHB/GBL.", "Dose low and don't top up straight away - it may be that you don't get a high.", "With Sizzurp: The mixture with carbonic acid and sugar makes the codeine more difficult to dose. In addition, the effect is much faster and more intense.", "When codeine is injected or snorted, severe side effects and unintentional overdose can result.", "Codeine is a medicinal product and should therefore only be taken with medical supervision." ], "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 30, "commonMin": 100, "strongMin": 150, "heavyMin": 200 }, "duration": { "onset": { "min": 30, "max": 45, "units": "minutes" }, "comeup": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" } } } ] }, { "name": "Coluracetam", "commonNames": [ "Coluracetam" ], "url": "https://psychonautwiki.org/wiki/Coluracetam", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "racetam", "nootropic" ], "addictionPotential": "not addictive with a low potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "nootropic", "research-chemical" ], "summary": "A nootropic drug of the racetam class, originally developed to treat Alzheimer's disease, it is currently being investigated as a treatment for major depressive disorder and generalised anxiety disorder. May be a modulator of the AMPA receptor. Limited recreational value.", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 20 }, "duration": { "onset": { "min": 1, "max": 5, "units": "minutes" }, "total": { "min": 3, "max": 6, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 20 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 3, "max": 6, "units": "hours" } } } ] }, { "name": "Creatine", "commonNames": [ "Creatine", "N-Carbamimidoyl-N-methylglycine", "Methylguanidoacetic acid" ], "url": "https://psychonautwiki.org/wiki/Creatine", "isApproved": true, "crossTolerances": [], "addictionPotential": "not habit-forming with a low potential for abuse", "toxicities": [], "categories": [ "nootropic" ], "roas": [ { "name": "oral", "dose": { "units": "g", "lightMin": 0.25, "commonMin": 5, "strongMin": 10, "heavyMin": 20 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 30, "max": 36, "units": "hours" } } } ] }, { "name": "Cyclazodone", "commonNames": [ "Cyclazodone" ], "url": "https://psychonautwiki.org/wiki/Cyclazodone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 25, "heavyMin": 40 }, "duration": { "onset": { "min": 20, "max": 45, "units": "minutes" }, "total": { "min": 5, "max": 7, "units": "hours" } } } ] }, { "name": "Datura", "commonNames": [ "Datura", "Jimson Weed" ], "url": "https://psychonautwiki.org/wiki/Datura", "isApproved": true, "tolerance": { "full": "with repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [], "addictionPotential": "mildly addictive with a high potential for adverse side effects such as psychosis", "toxicities": [ "toxic dosage is unknown" ], "categories": [ "deliriant", "depressant", "tentative" ], "summary": "A family of plants containing various Tropane alkaloids. Produces long-lasting deliriant effects including very realistic and often unpleasant hallucinations along with short-term amnesia. Datura plants are toxic to humans, and potency varies greatly from plant-to-plant, making the drug extremely difficult to dose safely. Not typically regarded as recreational.", "roas": [ { "name": "oral", "duration": { "onset": { "min": 20, "max": 120, "units": "minutes" }, "comeup": { "min": 60, "max": 120, "units": "minutes" } } } ] }, { "name": "Deschloroetizolam", "commonNames": [ "Deschloroetizolam" ], "url": "https://psychonautwiki.org/wiki/Deschloroetizolam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepine", "thienodiazepine" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "research-chemical", "habit-forming", "tentative" ], "summary": "A Thienodiazepine which is close to its parent compound, Etizolam, whilst being significantly weaker and longer lasting.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 4, "strongMin": 6, "heavyMin": 12 }, "duration": { "onset": { "min": 1, "max": 5, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 8, "max": 10, "units": "hours" }, "afterglow": { "min": 3, "max": 6, "units": "hours" } } } ] }, { "name": "Deschloroketamine", "commonNames": [ "Deschloroketamine", "DCK", "DXE", "O-PCM" ], "url": "https://psychonautwiki.org/wiki/Deschloroketamine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative", "research-chemical", "habit-forming", "tentative" ], "summary": "A novel analogue of Ketamine which is much more potent and has a longer duration.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 25, "heavyMin": 40 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 3, "max": 24, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 20, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 3, "max": 24, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 20, "heavyMin": 40 }, "duration": { "total": { "min": 30, "max": 90, "units": "minutes" } } } ] }, { "name": "Desomorphine", "commonNames": [ "Desomorphine", "Krokodil", "Krok" ], "url": "https://psychonautwiki.org/wiki/Desomorphine", "isApproved": true, "crossTolerances": [ "opioids" ], "toxicities": [], "categories": [ "opioid" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 15, "strongMin": 20, "heavyMin": 30 }, "duration": { "total": { "min": 3, "max": 4, "units": "hours" } } } ] }, { "name": "Desoxypipradrol", "commonNames": [ "Desoxypipradol", "2-DPMP", "Ivory Wave" ], "url": "https://psychonautwiki.org/wiki/Desoxypipradrol", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 0.25, "commonMin": 1.5, "strongMin": 3.5, "heavyMin": 5 }, "duration": { "onset": { "min": 15, "max": 240, "units": "minutes" }, "comeup": { "min": 2, "max": 6, "units": "hours" }, "peak": { "min": 6, "max": 30, "units": "hours" }, "offset": { "min": 6, "max": 40, "units": "hours" }, "total": { "min": 10, "max": 72, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 0.25, "commonMin": 2, "strongMin": 6, "heavyMin": 8 }, "duration": { "onset": { "min": 1, "max": 4, "units": "hours" }, "peak": { "min": 9, "max": 30, "units": "hours" }, "offset": { "min": 6, "max": 40, "units": "hours" }, "total": { "min": 16, "max": 72, "units": "hours" } } } ] }, { "name": "DET", "commonNames": [ "Diethyltryptamine", "DET" ], "url": "https://psychonautwiki.org/wiki/DET", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical", "tentative" ], "summary": "A surprisingly uncommon analogue of DMT with similar effects and reported oral activity without the aid of an MAOI.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 40, "strongMin": 70, "heavyMin": 100 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "afterglow": { "min": 2, "max": 8, "units": "hours" } } } ] }, { "name": "Dextromethorphan", "commonNames": [ "DXM", "DMO", "DM", "Dex", "Robitussin", "Delsym", "DexAlone", "Duract" ], "url": "https://psychonautwiki.org/wiki/Dextromethorphan", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociatives" ], "addictionPotential": "produces dependence with chronic use and has moderate abuse potential", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative" ], "effectsSummary": "In high doses (120 mg or more) it has a hallucinogenic and euphoric effect. Perceptual disturbances up to confusion as well as states of agitation with epileptic episodes may occur. Side effects are reddening of the skin and severe itching. With regular use there is great potential for dependence with psychological and physical symptoms!", "dosageRemark": "DXM in freebase form (as found in Robocough RoboTablets) is around 27-37% more potent than its hydrobromide form due to a higher concentration of DXM by weight. One should take this into account when calculating their dose to avoid a potential overdose.", "generalRisks": "Caution: The simultaneous intake of MAO inhibitors delays the degradation of DXM and can lead to severe respiratory and circulatory disorders!", "saferUse": [], "interactions": { "dangerous": [ "ΑMT", "PCP", "MDMA", "Alcohol", "GHB", "GBL", "Opioids", "Tramadol", "MAOI", "SSRIs", "Antihistamine" ], "unsafe": [ "DOx", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "Substituted amphetamines", "Cocaine" ], "uncertain": [ "Benzodiazepines", "Cannabis" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 75, "commonMin": 200, "strongMin": 400, "heavyMin": 700 }, "duration": { "onset": { "min": 30, "max": 120, "units": "minutes" }, "comeup": { "min": 60, "max": 120, "units": "minutes" }, "peak": { "min": 3, "max": 6, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 4, "max": 24, "units": "hours" } } } ] }, { "name": "Dextropropoxyphene", "commonNames": [ "Dextropropoxyphene", "Propoxyphene", "Darvon" ], "url": "https://psychonautwiki.org/wiki/Dextropropoxyphene", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "high toxicity", "potentially lethal when mixed with depressants like alcohol or benzodiazepines", "known to cause potentially fatal heart arrhythmias" ], "categories": [ "opioid", "depressant", "habit-forming" ], "summary": "An opioid analgesic that is an optical isomer of levopropoxyphene. Used to treat mild pain and often used for its antitussive properties. It has been taken off the market in Europe and US due to concerns of health issues relating to the Kidney, Liver, Heart and Respiratory Disorders. Just a bit stronger than Tramadol.", "interactions": { "dangerous": [ "SNRIs", "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 15, "commonMin": 65, "strongMin": 100, "heavyMin": 200 }, "duration": { "onset": { "min": 20, "max": 30, "units": "minutes" }, "peak": { "min": 1, "max": 4, "units": "hours" }, "afterglow": { "min": 1, "max": 6, "units": "hours" } } } ] }, { "name": "Diazepam", "commonNames": [ "Valium", "Diastat", "Mother's Little Helper", "Apaurin" ], "url": "https://psychonautwiki.org/wiki/Diazepam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7-14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "habit-forming", "common" ], "summary": "A very common and widely prescribed benzodiazepine with hypnotic and sedative qualities. The metre by which other benzodiazepines are compared. May cause amnesia and lowered inhibitions in excess. Has a relatively long half-life in comparison with other benzodiazepines.", "effectsSummary": "Diazepam has a calming, relaxing, antispasmodic, anti-anxiety and sleep-inducing effect.\nTaking benzodiazepines increases the effectiveness of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This triggers sedative (calming), hypnotic, anxiolytic (anxiety-relieving), anticonvulsant (anticonvulsant) and muscle-relaxing effects in the body. Benzodiazepines have a depressant effect on the central nervous system. The flow of information in the brain between the brain cells (neurons) is thereby reduced / disturbed and feelings and perceptions are dampened.\nThe breakdown of the individual active ingredients of benzodiazepines in the body is age-dependent and therefore varies from person to person.", "generalRisks": "There is little information available on risks, toxicity, side effects and long-term consequences. Therefore, the general information on benzodiazepines applies:\nWhen mixing with other downers (alcohol, GHB/GBL, heroin) there is a risk of respiratory paralysis!\nTaking benzodiazepines can cause numerous undesirable side effects. In addition, regular and long-term use carries a very high risk of physical and psychological dependence. Benzodiazepines should only be taken as prescribed by a doctor and only for a short period of time (max. 4-6 weeks). Longer-term use should be discussed with the treating specialist. The dosages and duration of action of the individual benzodiazepines differ considerably.\nSide effects of benzodiazepines may be as follows: Prolonged fatigue, gastrointestinal problems, impaired reactions, hypersensitivity reactions, headaches, dizziness, motor difficulties, visual disturbances, slowed breathing, muscle weakness, confusion, sexual dysfunction, aggression, outbursts of anger, restlessness, random movements, allergies, skin problems/rashes and speech and movement disorders. Some benzodiazepines can cause seizures in epileptics.", "longtermRisks": "Regular and long-term use can lead to psychological and physical dependence (very high dependence potential). Immediate discontinuation of the drug after prolonged use can lead to negative withdrawal symptoms (including dizziness, physical weakness, inner restlessness, tremors, sleep disturbances, headaches, sweating, nausea, hallucinations and depression).\nIn addition, seizures and memory disorders/loss and listlessness (hangover effects) can occur. In case of possible dependence, withdrawal should be discussed with a doctor beforehand and the withdrawal should be medically accompanied. It is extremely important that the dose is reduced gradually.", "saferUse": [ "If medicines are obtained on the black market or on the internet and not from a pharmacy/medical facility, the contents are unclear. Have the medicine tested for the exact ingredients in a drug check!", "Do not rely on dosage information from colleagues who regularly use benzodiazepines. Due to habituation or dependence, their doses can be much higher and fatal for new users.", "Blisters of counterfeits may look identical to the original packaging.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, opioids and/or other benzodiazepines is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!" ], "interactions": { "dangerous": [ "Depressant", "Dissociatives", "Stimulants" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 15, "heavyMin": 30 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 12, "max": 36, "units": "hours" } } } ] }, { "name": "Dichloropane", "commonNames": [ "Dichloropane", "RTI-111" ], "url": "https://psychonautwiki.org/wiki/Dichloropane", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "2 - 4 days", "zero": "1 - 1.5 weeks", "halfToleranceInHours": 72, "zeroToleranceInHours": 210 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "MAOI" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 3, "commonMin": 20, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 60, "max": 90, "units": "minutes" }, "total": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 2.5, "commonMin": 7.5, "strongMin": 20, "heavyMin": 50 }, "duration": { "onset": { "min": 15, "max": 60, "units": "seconds" }, "comeup": { "min": 15, "max": 60, "units": "seconds" }, "peak": { "min": 15, "max": 30, "units": "minutes" }, "offset": { "min": 20, "max": 40, "units": "minutes" }, "total": { "min": 40, "max": 75, "units": "minutes" } } } ] }, { "name": "Diclazepam", "commonNames": [ "Diclazepam" ], "url": "https://psychonautwiki.org/wiki/Diclazepam", "isApproved": true, "tolerance": { "full": "within 3-4 days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "GABAergic" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "habit-forming" ], "summary": "A benzodiazepine drug and analogue of diazepam first synthesised by Leo Sternbach at Hoffman-LaRoche in 1960, it has become prominent as an RC benzodiazepine on the grey market in recent years, particularly with the decline in etizolam availability. A sedative and hypnotic it is of intermediate to long half life with similar effects to diazepam, though 10x more potent.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 1, "strongMin": 3, "heavyMin": 4 }, "duration": { "onset": { "min": 10, "max": 45, "units": "minutes" }, "total": { "min": 8, "max": 12, "units": "hours" } } } ] }, { "name": "Dihydrocodeine", "commonNames": [ "Dihydrocodeine" ], "url": "https://psychonautwiki.org/wiki/Dihydrocodeine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or benzodiazepines" ], "categories": [ "opioid", "habit-forming", "depressant" ], "summary": "A weak semi-synthetic opioid analgesic and antitussive (anti-cough) drug. Often sold as a syrup in combination with aspirin or paracetamol. Not to be confused with the slightly less potent codeine.", "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 100, "strongMin": 150, "heavyMin": 200 }, "duration": { "total": { "min": 3, "max": 4, "units": "hours" } } } ] }, { "name": "Diphenhydramine", "commonNames": [ "DPH", "Benadryl", "Nytol", "Sominex", "Unisom SleepMelts", "ZzzQuil" ], "url": "https://psychonautwiki.org/wiki/Diphenhydramine", "isApproved": true, "tolerance": { "full": "with repeated use", "zero": "1 - 2 weeks", "zeroToleranceInHours": 252 }, "crossTolerances": [ "deliriant" ], "addictionPotential": "produces dependence with chronic use", "toxicities": [ "fatal at amounts close to or exceeding 2 grams" ], "categories": [ "deliriant", "depressant" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 200, "strongMin": 400, "heavyMin": 700 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 1, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 6, "units": "hours" }, "total": { "min": 3, "max": 10, "units": "hours" }, "afterglow": { "max": 24, "units": "hours" } } } ] }, { "name": "Diphenidine", "commonNames": [ "Diphenidine" ], "url": "https://psychonautwiki.org/wiki/Diphenidine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative", "research-chemical", "habit-forming", "tentative" ], "summary": "A dissociative anaesthetic related to ephenidine with similar qualities to PCP and ketamine. Has seen some popularity as a recreational RC. Dosage curve has been reported as particularly steep, so care should be taken.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 30, "commonMin": 65, "strongMin": 100, "heavyMin": 130 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 2, "max": 5, "units": "hours" }, "afterglow": { "min": 4, "max": 24, "units": "hours" } } }, { "name": "rectal", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 40, "heavyMin": 80 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "total": { "min": 5, "max": 7, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "commonMin": 20, "strongMin": 40, "heavyMin": 55 }, "duration": { "onset": { "min": 30, "max": 90, "units": "seconds" }, "peak": { "min": 0.5, "max": 2, "units": "hours" }, "offset": { "min": 20, "max": 40, "units": "minutes" }, "total": { "min": 1, "max": 3, "units": "hours" }, "afterglow": { "min": 2, "max": 5, "units": "hours" } } } ] }, { "name": "DiPT", "commonNames": [ "DiPT" ], "url": "https://psychonautwiki.org/wiki/DiPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A rare tryptamine psychedelic closely related to DMT, with the interesting property of having little visual hallucinations, but strong auditory effects.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 15, "commonMin": 30, "strongMin": 75, "heavyMin": 150 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 20, "heavyMin": 30 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "total": { "min": 15, "max": 60, "units": "minutes" } } } ] }, { "name": "DMT", "commonNames": [ "DMT", "N,N-DMT", "Dmitry", "The Glory", "The Spirit Molecule" ], "url": "https://psychonautwiki.org/wiki/DMT", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "psychedelic", "common" ], "summary": "A popular and powerful psychedelic, typically used in two ways; either it is vapourised for a short 'breakthrough' experience, or it is taken in combination with an enzyme inhibitor for a long, intense trip (this is also known as ayahuasca or pharmahuasca).", "effectsSummary": "The effect depends very much on the set and the setting. Blood pressure and pulse increase, pupils dilate. Detachment of the body from the mind and ego dissolution are common, near-death experiences also occur relatively often, especially when high doses are consumed. The perception of time changes greatly during intoxication. A few minutes can be perceived as very long and intense. In addition, different feelings such as fear, euphoria, etc. can be experienced within a short period of time. Consumers report immersion in very \"bizarre\" worlds in which connections between being, environment and matter arise. With DMT, this phenomenon is also visually pronounced, i.e., images are linked with oneself, matter and being in one's own society. Physical perception can also be influenced, in that one feels weightless or thinks one is falling.\nWhen swallowed, DMT is only effective in combination with MAO inhibitors. MAO inhibitors (e.g. harmine) are substances and drugs that prevent the enzyme MAO from breaking down the body's own messenger substances such as adrenaline, dopamine, serotonin etc. as well as foreign alkaloids such as caffeine, cocaine, morphine. The psychoactive potion ayahuasca and changa are such a combination. After the consumption of MAO inhibitors, the consumption of certain everyday foods such as cheese is life-threatening.", "dosageRemark": "Ayahuasca is a shamanic herbal potion made from DMT-containing chacruna leaves (Psychotria viridis) and the harmaline-containing ayahuasca liana Banisteriopsis caapi. Harmaline is an MAO inhibitor. MAO inhibitors are substances and drugs that prevent the enzyme MAO from breaking down the body's own messenger substances such as adrenalin, dopamine, serotonin, etc. as well as foreign alkaloids such as caffeine, cocaine, etc.. MAO normally also degrades the active substance DMT even before it can enter the central nervous system via the blood-brain barrier.\nChanga is a mixture for smoking of DMT-containing plants (but usually mostly crystalline DMT) and herbs that act as MAO inhibitors.", "generalRisks": "The risk associated with the use of DMT is mainly psychological and depends on the personality structure of the user. The perceptual changes during a trip can be so intense that especially inexperienced users feel overwhelmed by the flood of impressions. The perception of sudden emotional outbursts can also be perceived as rather disturbing and overwhelming. At high doses, such psychological side effects can be felt for days to weeks. If the rules of the set and setting are not followed, there can be false reactions, loss of orientation, panic, paranoia and horror trips. Physical side effects include nausea, vomiting, increase in heart rate, slightly accelerated breathing, increased blood pressure, pupil dilation, increased salivation, tremors, restlessness, headaches and movement disorders.", "longtermRisks": "Permanent disturbances in self- and reality recognition are possible. The view of the world can be permanently called into question, which can make it difficult to cope with everyday life. Latent (hidden) psychoses can be triggered.", "saferUse": [ "Only consume when you feel good. If you are afraid of the strong effects, do not use. Do not use if you are afraid of the substance.", "Do not use DMT alone! Take it in a safe atmosphere and together with experienced people you trust.", "Take DMT while sitting or lying down, as physical perception and ability to move are impaired during intoxication.", "Dose carefully at first. If there is no effect, increase the dose the next time. Do not add more on the same day.", "The consumption of MAO-inhibiting foods such as matured cheese, smoked fish or meat, sauerkraut, tofu, chocolate etc. should be avoided before and after consumption.", "People with high blood pressure should not consume DMT.", "A trip with DMT should remain an exceptional experience. Make sure you take long breaks from using DMT and talk to others about your experience so that it can be processed." ], "roas": [ { "name": "intravenous", "dose": { "units": "mg", "lightMin": 4, "commonMin": 10, "strongMin": 15, "heavyMin": 20 }, "duration": { "onset": { "min": 2, "max": 10, "units": "seconds" }, "comeup": { "min": 70, "max": 100, "units": "seconds" }, "peak": { "min": 2, "max": 5, "units": "minutes" }, "offset": { "min": 10, "max": 20, "units": "minutes" }, "total": { "min": 15, "max": 30, "units": "minutes" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 2, "commonMin": 20, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 20, "max": 40, "units": "seconds" }, "comeup": { "min": 1, "max": 3, "units": "minutes" }, "peak": { "min": 2, "max": 8, "units": "minutes" }, "offset": { "min": 1, "max": 6, "units": "minutes" }, "total": { "min": 5, "max": 20, "units": "minutes" }, "afterglow": { "min": 10, "max": 60, "units": "minutes" } } } ] }, { "name": "DMXE", "commonNames": [], "url": "https://psychonautwiki.org/wiki/DMXE", "isApproved": false, "crossTolerances": [], "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative" ], "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 35, "heavyMin": 60 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "comeup": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 1, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "DOB", "commonNames": [ "DOB", "Brolamfetamine", "Bromo-DMA" ], "url": "https://psychonautwiki.org/wiki/DOB", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "4-7 days", "zero": "7-10 days", "halfToleranceInHours": 132, "zeroToleranceInHours": 204 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "stimulant", "research-chemical" ], "summary": "DOB is a relatively uncommon synthetic psychedelic. It is best known for its very low doses and long duration. Historically it has rarely been taken deliberately, but in place of LSD, however it has recently found its own place in the research chemical scene.", "effectsSummary": "At the beginning, typical effects of amphetamine unfold, such as increased alertness, accelerated pulse, slight euphoria, increased self-confidence and urge to talk. Afterwards, the effect changes: one often feels a strong urge to move, sensory perception, feelings and empathy are heightened, colours are perceived more distinctly. With DOB and DOI, coloured, superimposed, pulsating patterns are perceived. This effect is weaker with DOM.", "generalRisks": "Since the effect of DOB comes on late, the danger of overdosing by refilling is particularly great. The long duration of action poses a psychological burden. Confusion or anxiety is common, especially at high doses. Some DOB users report a burning or pressure sensation in the bladder. At high doses, temporary paralysis, inability to communicate or insensitivity to pain (caution: risk of injury and accidents) may occur. Teeth grinding and strain on the cardiovascular system are also possible.", "longtermRisks": "Due to the long and intense effects, use - especially frequent use - carries the risk of a loss of reality, which can manifest itself in schizophrenic traits and anxiety states. The consumption of DOB can trigger latent (hidden) psychoses.", "saferUse": [ "DOB are not suitable as party drugs and should only be used by experienced users.", "Plan your trip ahead because of the long duration of action.", "Never consume DOB alone and only when you feel very well mentally and physically and are well rested!", "Pay attention to set and setting: only take DOB in a place where you feel safe and avoid unwanted disturbances from outside! Prepare yourself well for the trip and prepare yourself internally for the long duration of the effect.", "Drink enough water during the trip.", "Mixed use of these potent substances should be avoided at all costs.", "As amphetamine derivatives, DOB can be particularly draining because of their long duration of action. Light vitamin-rich food, fruits, vegetable juices, vitamins and minerals promote a soft landing after the trip has subsided and can weaken a hangover.", "Plan enough time for recovery after the trip (at least 1 day)!", "A trip with DOB should remain an exceptional experience. Make sure to take long breaks from consumption so that the experience can be processed." ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.2, "commonMin": 0.75, "strongMin": 1.75, "heavyMin": 3 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "comeup": { "min": 2, "max": 4, "units": "hours" }, "peak": { "min": 6, "max": 10, "units": "hours" }, "offset": { "min": 4, "max": 8, "units": "hours" }, "total": { "min": 14, "max": 24, "units": "hours" }, "afterglow": { "min": 4, "max": 16, "units": "hours" } } } ] }, { "name": "DOC", "commonNames": [ "DOC" ], "url": "https://psychonautwiki.org/wiki/DOC", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "stimulant", "research-chemical", "common" ], "summary": "A potent stimulating psychedelic with a long action, a phenethylamine and substituted amphetamine. Sometimes sold as LSD but also enjoyed on its own merits by many. Usually sold on blotters slightly larger than those LSD is found on, but can also be bought in powder form.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 0.25, "commonMin": 1, "strongMin": 2, "heavyMin": 3.5 }, "duration": { "onset": { "min": 1, "max": 5, "units": "minutes" }, "comeup": { "min": 10, "max": 30, "units": "minutes" }, "peak": { "min": 2, "max": 6, "units": "hours" }, "offset": { "min": 2, "max": 8, "units": "hours" }, "afterglow": { "min": 2, "max": 24, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 2, "strongMin": 4, "heavyMin": 6 }, "duration": { "onset": { "min": 1, "max": 2, "units": "hours" }, "comeup": { "min": 2, "max": 3, "units": "hours" }, "peak": { "min": 6, "max": 12, "units": "hours" }, "offset": { "min": 2, "max": 8, "units": "hours" }, "total": { "min": 12, "max": 24, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "DOI", "commonNames": [ "DOI" ], "url": "https://psychonautwiki.org/wiki/DOI", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "10-14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 288 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "stimulant", "research-chemical" ], "summary": "A potent, long-acting psychedelic stimulant. Historically, it has rarely been consumed deliberately, but occasionally sold as LSD. However, it has recently found its own little nest in the research chemical community.", "effectsSummary": "At the beginning, typical effects of amphetamine unfold, such as increased alertness, accelerated pulse, slight euphoria, increased self-confidence and urge to talk. Afterwards, the effect changes: one often feels a strong urge to move, sensory perception, feelings and empathy are heightened, colours are perceived more distinctly. With DOB and DOI, coloured, superimposed, pulsating patterns are perceived. This effect is weaker with DOM.", "generalRisks": "Since the effect of DOI comes on late, the danger of overdosing by refilling is particularly great. The long duration of action poses a psychological burden. Confusion or anxiety is common, especially at high doses. Some DOB users report a burning or pressure sensation in the bladder. At high doses, temporary paralysis, inability to communicate or insensitivity to pain (caution: risk of injury and accidents) may occur. Teeth grinding and strain on the cardiovascular system are also possible.", "longtermRisks": "Due to the long and intense effects, use - especially frequent use - carries the risk of a loss of reality, which can manifest itself in schizophrenic traits and anxiety states. The consumption of DOI can trigger latent (hidden) psychoses.", "saferUse": [ "DOM are not suitable as party drugs and should only be used by experienced users.", "Plan your trip ahead because of the long duration of action.", "Never consume DOI alone and only when you feel very well mentally and physically and are well rested!", "Pay attention to set and setting: only take DOI in a place where you feel safe and avoid unwanted disturbances from outside! Prepare yourself well for the trip and prepare yourself internally for the long duration of the effect.", "Drink enough water during the trip.", "Mixed use of these potent substances should be avoided at all costs.", "As amphetamine derivatives, DOI can be particularly draining because of their long duration of action. Light vitamin-rich food, fruits, vegetable juices, vitamins and minerals promote a soft landing after the trip has subsided and can weaken a hangover.", "Plan enough time for recovery after the trip (at least 1 day)!", "A trip with DOI should remain an exceptional experience. Make sure to take long breaks from consumption so that the experience can be processed." ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 1, "strongMin": 2, "heavyMin": 3 }, "duration": { "onset": { "min": 1, "max": 2, "units": "hours" }, "comeup": { "min": 1.5, "max": 3, "units": "hours" }, "total": { "min": 16, "max": 24, "units": "hours" } } } ] }, { "name": "DOM", "commonNames": [ "DOM", "STP (Serenity, Tranquility, and Peace)" ], "url": "https://psychonautwiki.org/wiki/DOM", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "stimulant", "research-chemical", "common" ], "summary": "The most popular psychedelic amphetamine due to its pleasant effects, lower potency and shorter duration. Effects have been described as 'sillier' than LSD and related DOX chemicals", "effectsSummary": "At the beginning, typical effects of amphetamine unfold, such as increased alertness, accelerated pulse, slight euphoria, increased self-confidence and urge to talk. Afterwards, the effect changes: one often feels a strong urge to move, sensory perception, feelings and empathy are heightened, colours are perceived more distinctly. With DOB and DOI, coloured, superimposed, pulsating patterns are perceived. This effect is weaker with DOM.", "generalRisks": "Since the effect of DOM comes on late, the danger of overdosing by refilling is particularly great. The long duration of action poses a psychological burden. Confusion or anxiety is common, especially at high doses. Some DOB users report a burning or pressure sensation in the bladder. At high doses, temporary paralysis, inability to communicate or insensitivity to pain (caution: risk of injury and accidents) may occur. Teeth grinding and strain on the cardiovascular system are also possible.", "longtermRisks": "Due to the long and intense effects, use - especially frequent use - carries the risk of a loss of reality, which can manifest itself in schizophrenic traits and anxiety states. The consumption of DOM can trigger latent (hidden) psychoses.", "saferUse": [ "DOM are not suitable as party drugs and should only be used by experienced users.", "Plan your trip ahead because of the long duration of action.", "Never consume DOM alone and only when you feel very well mentally and physically and are well rested!", "Pay attention to set and setting: only take DOM in a place where you feel safe and avoid unwanted disturbances from outside! Prepare yourself well for the trip and prepare yourself internally for the long duration of the effect.", "Drink enough water during the trip.", "Mixed use of these potent substances should be avoided at all costs.", "As amphetamine derivatives, DOM can be particularly draining because of their long duration of action. Light vitamin-rich food, fruits, vegetable juices, vitamins and minerals promote a soft landing after the trip has subsided and can weaken a hangover.", "Plan enough time for recovery after the trip (at least 1 day)!", "A trip with DOM should remain an exceptional experience. Make sure to take long breaks from consumption so that the experience can be processed." ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 3, "strongMin": 5, "heavyMin": 10 }, "duration": { "onset": { "min": 1, "max": 2, "units": "hours" }, "comeup": { "min": 2, "max": 3, "units": "hours" }, "peak": { "min": 6, "max": 8, "units": "hours" }, "offset": { "min": 3, "max": 5, "units": "hours" }, "total": { "min": 12, "max": 16, "units": "hours" }, "afterglow": { "min": 4, "max": 16, "units": "hours" } } } ] }, { "name": "DPT", "commonNames": [ "DPT", "Dipropyltryptamine", "The Light" ], "url": "https://psychonautwiki.org/wiki/DPT", "isApproved": true, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "N,N-Dipropyltryptamine, a psychedelic tryptamine compound and lesser-known analogue of DMT, with similar psychedelic effects. Like DMT it is a partial serotonin receptor agonist.", "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 50, "strongMin": 100, "heavyMin": 200 }, "duration": { "onset": { "min": 5, "max": 20, "units": "minutes" }, "peak": { "min": 30, "max": 45, "units": "minutes" }, "total": { "min": 3, "max": 5, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 150, "strongMin": 250, "heavyMin": 350 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "total": { "min": 2, "max": 4, "units": "hours" }, "afterglow": { "min": 2, "max": 3, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 10, "commonMin": 20, "strongMin": 50, "heavyMin": 100 }, "duration": { "total": { "min": 30, "max": 90, "units": "minutes" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "Ephedrine", "commonNames": [ "Ephedrine", "Ephedra" ], "url": "https://psychonautwiki.org/wiki/Ephedrine", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant", "habit-forming" ], "summary": "Ephedrine is a sympathomimetic amine commonly used as a stimulant, concentration aid, decongestant, appetite suppressant, and to treat hypotension associated with anaesthesia. A methamphetamine analogue and commonly used in the production of methamphetamine.", "effectsSummary": "Stimulates circulation, increases drive and performance, and suppresses appetite.", "generalRisks": "Even at low doses: Palpitations, restlessness, sleep problems, urinary urgency or retention and dry mouth. Also possible are feelings of anxiety, increased blood pressure (vasoconstriction), loss of appetite, dizziness, cardiac arrhythmias and even heart attacks.\nIn case of overdose: confusion and paranoia. The tannins of ephedra herb can cause stomach complaints in larger quantities.", "longtermRisks": "Continuous use: Impaired memory and concentration, irritability, nervousness, aggressive behaviour, cardiac arrhythmia, chronic high blood pressure, bad teeth, liver/kidney damage and psychological disorders. Regular ephedrine use can lead to the development of tolerance and dependence, especially with psychological symptoms.", "saferUse": [ "Take a low dose of ephedrine, as the active ingredient content can vary greatly, especially in herbs!", "Drink enough water (3 - 5 dl per hour) and no alcohol!", "People with circulatory problems/diseases, thyroid disorders and liver or kidney damage should not consume ephedrine!", "Ephedrine is not an effective means of losing weight without medical supervision." ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 20, "max": 90, "units": "minutes" }, "total": { "min": 2, "max": 5, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "Ephenidine", "commonNames": [ "Ephenidine", "NEDPA" ], "url": "https://psychonautwiki.org/wiki/Ephenidine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative", "research-chemical", "habit-forming", "tentative" ], "summary": "A dissociative drug which is less potent and less confusing than MXE but with otherwise similar properties. Reported as causing light stimulant effects at lower doses.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 30, "commonMin": 70, "strongMin": 100, "heavyMin": 150 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "total": { "min": 5, "max": 7, "units": "hours" } } } ] }, { "name": "Ephylone", "commonNames": [ "Ephylone", "bk-EBDP", "βk-EBDP", "bk-ethyl-K" ], "url": "https://psychonautwiki.org/wiki/Ephylone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use" }, "crossTolerances": [], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 40, "heavyMin": 80 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "EPT", "commonNames": [ "EPT" ], "url": "https://psychonautwiki.org/wiki/EPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "does not produce dependence and has low abuse potential", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "tentative", "research-chemical" ], "summary": "Ethylpropyltryptamine a novel tryptamine, that is the structural homologue of DMT.", "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 20, "commonMin": 40, "strongMin": 80, "heavyMin": 110 }, "duration": { "onset": { "min": 5, "max": 20, "units": "minutes" }, "total": { "min": 2, "max": 4, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } } ] }, { "name": "Escaline", "commonNames": [ "Escaline" ], "url": "https://psychonautwiki.org/wiki/Escaline", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "First synthesised in the 50s, this uncommon drug was reexamined by David Nichols in the 1990s. It is an analogue of mescaline which is roughly six times more potent, and is thus a powerful psychedelic phenethylamine. Subjective effects may include stimulation and hallucinations.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 50, "strongMin": 100, "heavyMin": 150 }, "duration": { "onset": { "min": 90, "max": 120, "units": "minutes" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 3, "max": 5, "units": "hours" } } } ] }, { "name": "Eszopiclone", "commonNames": [ "Lunesta", "Eszop" ], "url": "https://psychonautwiki.org/wiki/Eszopiclone", "isApproved": false, "tolerance": { "full": "within a couple of weeks of daily use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like benzodiazepines, alcohol or opioids" ], "categories": [ "hallucinogen", "depressant", "hypnotic", "habit-forming" ], "summary": "The d-isomer of Zopiclone, this drug is a potent hypnotic 'Z' drug often used to treat insomnia. High doses may cause amnesia, delirium and lowered inhibitions. Should not be combined with any depressants. Limited recreational value.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 2, "strongMin": 4, "heavyMin": 6 }, "duration": { "onset": { "min": 10, "max": 20, "units": "minutes" }, "peak": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 6, "max": 8, "units": "hours" } } } ] }, { "name": "ETH-CAT", "commonNames": [ "ETH-CAT", "Ethcathinone", "Ethylpropion" ], "url": "https://psychonautwiki.org/wiki/ETH-CAT", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "2 - 3 days", "zero": "3-5 days", "halfToleranceInHours": 60, "zeroToleranceInHours": 96 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "mildly addictive with a comparatively low potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "MAOI", "25x-NBOMe", "25x-NBOH", "Tramadol" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 35, "strongMin": 70, "heavyMin": 100 }, "duration": { "onset": { "min": 1, "max": 5, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 2, "max": 3, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 60, "commonMin": 150, "strongMin": 225, "heavyMin": 325 }, "duration": { "onset": { "min": 15, "max": 40, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 60, "max": 120, "units": "minutes" }, "total": { "min": 3, "max": 5, "units": "hours" } } } ] }, { "name": "ETH-LAD", "commonNames": [ "ETH-LAD" ], "url": "https://psychonautwiki.org/wiki/ETH-LAD", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A psychedelic drug and slightly more potent analogue of LSD, first synthesised by Alexander Shulgin - sometimes described as being less 'abrasive' than LSD. Less common than the associated AL-LAD, though has seen some popularity since its release on the Internet research chemical scene in 2015.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 15, "commonMin": 60, "strongMin": 150, "heavyMin": 225 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 4, "max": 6, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 8, "max": 48, "units": "hours" } } } ] }, { "name": "Ethylmorphine", "commonNames": [ "Ethylmorphine", "Codethyline", "Dionine" ], "url": "https://psychonautwiki.org/wiki/Ethylmorphine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "very addictive with a high potential for abuse", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or benzodiazepines" ], "categories": [ "opioid", "habit-forming", "depressant" ], "summary": "A medium-strength opioid analgesic and analogue of morphine. Considered less potent than morphine but more potent than codeine, and has been used in Germany for this reason. Said to have a 'ceiling' effect where no more euphoria occurs with increased dosage. Under investigation as a maintainance drug in opioid dependence therapy.", "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 50, "strongMin": 100, "heavyMin": 200 }, "duration": { "total": { "min": 4, "max": 5, "units": "hours" } } } ] }, { "name": "Ethylone", "commonNames": [ "Ethylone", "bk-MDEA", "MDEC" ], "url": "https://psychonautwiki.org/wiki/Ethylone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "psychedelic", "research-chemical", "habit-forming", "entactogen" ], "summary": "A euphoric stimulant often sold in place of MDMA since methylone was banned. Slightly less potent and empathogenic than methylone, it is often described as more of a 'straight stimulant.'", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 75, "commonMin": 150, "strongMin": 225, "heavyMin": 325 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 60, "max": 120, "units": "minutes" }, "total": { "min": 2, "max": 4, "units": "hours" }, "afterglow": { "min": 2, "max": 12, "units": "hours" } } } ] }, { "name": "Ethylphenidate", "commonNames": [ "Ethylphenidate", "EPH" ], "url": "https://psychonautwiki.org/wiki/Ethylphenidate", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopaminergic", "stimulants" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "research-chemical", "habit-forming", "common" ], "summary": "Potent psychostimulant, similar to Methylphenidate. \u0002Note: Ethylphenidate should \u0016NOT\u0016 be insufflated as it is known to be highly caustic and will cause serious harm to your nasal septum, even with light usage.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 40, "strongMin": 80, "heavyMin": 120 }, "duration": { "onset": { "min": 40, "max": 120, "units": "minutes" }, "total": { "min": 4, "max": 7, "units": "hours" } } }, { "name": "rectal", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 5, "max": 20, "units": "minutes" }, "total": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "Etizolam", "commonNames": [ "Etizolam", "Etilaam", "Etizest" ], "url": "https://psychonautwiki.org/wiki/Etizolam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepine", "thienodiazepine" ], "addictionPotential": "highly addictive with a high potential for abuse", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "research-chemical", "habit-forming" ], "summary": "A thienodiazepine anxiolytic. Similar in action to benzodiazepine drugs. Relieves anxiety, causes sedation and mild euphoria. High doses can lead to losing memory of what happened while on the drug. Users often compulsively re-dose frequently leading to accidental blackouts. Can be found in pressed pharmaceutical pills from various countries, clandestine pill presses, or as a powder", "effectsSummary": "Etizolam is a research chemical with anti-anxiety, anticonvulsant, sedative and sleep-inducing properties.\nAs it is a little-researched substance, only vague information is available regarding its effect.\nTaking benzodiazepines increases the effectiveness of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This triggers sedative (calming), hypnotic, anxiolytic (anxiety-relieving), anticonvulsant (anticonvulsant) and muscle-relaxing effects in the body. Benzodiazepines have a depressant effect on the central nervous system. The flow of information in the brain between the brain cells (neurons) is thereby reduced / disturbed and feelings and perceptions are dampened.\nThe breakdown of the individual active ingredients of benzodiazepines in the body is age-dependent and therefore varies from person to person.", "dosageRemark": "0.75 mg etizolam corresponds to 10 mg diazepam", "generalRisks": "There is little information available on risks, toxicity, side effects and long-term consequences. Therefore, the general information on benzodiazepines applies:\nWhen mixing with other downers (alcohol, GHB/GBL, heroin) there is a risk of respiratory paralysis!\nTaking benzodiazepines can cause numerous undesirable side effects. In addition, regular and long-term use carries a very high risk of physical and psychological dependence. Benzodiazepines should only be taken as prescribed by a doctor and only for a short period of time (max. 4-6 weeks). Longer-term use should be discussed with the treating specialist. The dosages and duration of action of the individual benzodiazepines differ considerably.\nSide effects of benzodiazepines may be as follows: Prolonged fatigue, gastrointestinal problems, impaired reactions, hypersensitivity reactions, headaches, dizziness, motor difficulties, visual disturbances, slowed breathing, muscle weakness, confusion, sexual dysfunction, aggression, outbursts of anger, restlessness, random movements, allergies, skin problems/rashes and speech and movement disorders. Some benzodiazepines can cause seizures in epileptics.", "longtermRisks": "Regular and long-term use can lead to psychological and physical dependence (very high dependence potential). Immediate discontinuation of the drug after prolonged use can lead to negative withdrawal symptoms (including dizziness, physical weakness, inner restlessness, tremors, sleep disturbances, headaches, sweating, nausea, hallucinations and depression).\nIn addition, seizures and memory disorders/loss and listlessness (hangover effects) can occur. In case of possible dependence, withdrawal should be discussed with a doctor beforehand and the withdrawal should be medically accompanied. It is extremely important that the dose is reduced gradually.", "saferUse": [ "If medicines are obtained on the black market or on the internet and not from a pharmacy/medical facility, the contents are unclear. Have the medicine tested for the exact ingredients in a drug check!", "Do not rely on dosage information from colleagues who regularly use benzodiazepines. Due to habituation or dependence, their doses can be much higher and fatal for new users.", "Blisters of counterfeits may look identical to the original packaging.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, opioids and/or other benzodiazepines is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.2, "commonMin": 1, "strongMin": 2, "heavyMin": 5 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1.5, "max": 2.5, "units": "hours" }, "total": { "min": 5, "max": 7, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "F-Phenibut", "commonNames": [ "F-Phenibut", "Fluorophenibut", "Fluorobut" ], "url": "https://psychonautwiki.org/wiki/F-Phenibut", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "GABA" ], "addictionPotential": "moderately physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol, benzodiazepines or opioids", "exact toxic dosage is unknown" ], "categories": [ "depressant" ], "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 150, "strongMin": 400, "heavyMin": 600 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "total": { "min": 6, "max": 8, "units": "hours" } } } ] }, { "name": "Fentanyl", "commonNames": [ "Fentanyl", "fentanil", "Sublimaze", "Actiq", "Durogesic", "Duragesic", "Fentora", "Matrifen", "Haldid", "Onsolis", "Instanyl", "Abstral", "Lazanda" ], "url": "https://psychonautwiki.org/wiki/Fentanyl", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "extremely addictive with a high potential for abuse", "toxicities": [ "potentially fatal at heavy dosages", "potentially lethal when mixed with depressants like alcohol or benzodiazepines", "unintentionally transporting the substance from the skin by touching the mouth, nose or eyes is dangerous" ], "categories": [ "opioid", "habit-forming", "depressant", "common" ], "summary": "Fentanyl is a synthetic opiate analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors and is historically used to treat breakthrough pain. Fentanyl is approximately 100 times more potent than Morphine, and is commonly used as a patch. Sometimes used as an adulterant for heroin, which has led to many overdose deaths.", "effectsSummary": "Fentanyl has a strong analgesic and sedative effect and is effective in the smallest doses. However, its euphoric effect is less pronounced than that of other opioids. It is used in emergency medicine for surgical procedures and anesthesia, and for breakthrough pain in cancer patients. For chronic pain, fentanyl patches are used, which release the active ingredient slowly. Due to its opioid properties, fentanyl rapidly leads to dependence when taken over a long period of time and should not be discontinued abruptly and only under medical supervision.", "dosageRemark": "Fentanyl is extremely potent and therefore very difficult to dose. Therefore, overdoses can easily occur. When consuming for the first time, low doses should be used, as the risk of respiratory arrest is increased.", "generalRisks": "The side effects are strongly dose-dependent. As the dose increases, the side effects also become more pronounced. At the beginning there is often drowsiness, dizziness, dizziness, pupil constriction, slowed heartbeat, drop in blood pressure, nausea and vomiting.\nExcessive sweating, rashes, itching, central dullness, confusion, visual disturbances, cardiac arrhythmias, respiratory reflex depression and urinary retention may also occur.\nOverdoses with fentanyl are life-threatening because the substance, like all opioids, slows down breathing, even to the point of respiratory arrest and coma.", "longtermRisks": "Regular, abusive use of fentanyl can lead to dependence with severe withdrawal symptoms such as seizures, sleep disorders and depression. Withdrawal, as with all opioids, should not be abrupt and should only take place under medical supervision.", "saferUse": [ "Opioids are highly effective drugs that should only be used for a limited time and at best under medical supervision.", "Start with a low dose and wait for the effect and tolerance before adding more. Do not exceed the maximum daily dose.", "If you inject opioids, dose even more carefully, as the range between desired effect (rush) and dangerous overdose is even more difficult to assess. Avoid injecting fentanyl; the risk of overdose is particularly high. Always use new (clean and sterile) injection material! Never exchange syringes, filters, water, disinfection swabs to avoid transmission of hepatitis and HIV.", "Do not rely on dosage information from colleagues who regularly use opioids. Due to habituation or dependence, their doses are much higher and can be fatal for new users.", "Take longer breaks (at least several days) between consumption.", "After a period of abstinence, take a much lower dose! The usual dose before the abstinence phase can otherwise quickly have life-threatening consequences.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, benzodiazepines and/or other opioids is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!", "Refrain from citrus fruits (especially grapefruit) before or during consumption. The combination can lead to an increase in the effect of the opiate and/or to respiratory depression." ], "interactions": { "dangerous": [ "SNRIs", "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "µg", "lightMin": 5, "commonMin": 25, "strongMin": 50, "heavyMin": 75 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 1, "max": 4, "units": "hours" } } }, { "name": "sublingual", "dose": { "units": "µg", "lightMin": 5, "commonMin": 25, "strongMin": 50, "heavyMin": 75 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 1, "max": 4, "units": "hours" } } }, { "name": "transdermal", "dose": { "units": "µg", "lightMin": 5, "commonMin": 25, "strongMin": 50, "heavyMin": 100 }, "duration": { "onset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 48, "max": 72, "units": "hours" } } } ] }, { "name": "Flualprazolam", "commonNames": [ "Flualprazolam" ], "url": "https://psychonautwiki.org/wiki/Flualprazolam", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "depressant", "benzodiazepine", "habit-forming", "tentative", "research-chemical" ], "summary": "Fluorinated alprazolam, that likely has a longer half-life and higher potency than its parent compound.", "effectsSummary": "Flualprazolam has a sedative, muscle relaxant and anticonvulsant effect. Compared to the better-known active ingredient alprazolam , flualprazolam works in lower doses (more potent) and the onset of action is relatively rapid. According to user reports, flualprazolam has similar effects and side effects to alprazolam.\nAs it is a little-researched substance, only vague information is available regarding its effect.\nTaking benzodiazepines increases the effectiveness of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This triggers sedative (calming), hypnotic, anxiolytic (anxiety-relieving), anticonvulsant (anticonvulsant) and muscle-relaxing effects in the body. Benzodiazepines have a depressant effect on the central nervous system. The flow of information in the brain between the brain cells (neurons) is thereby reduced / disturbed and feelings and perceptions are dampened.\nThe breakdown of the individual active ingredients of benzodiazepines in the body is age-dependent and therefore varies from person to person.", "generalRisks": "There is little information available on risks, toxicity, side effects and long-term consequences. Therefore, the general information on benzodiazepines applies:\nWhen mixing with other downers (alcohol, GHB/GBL, heroin) there is a risk of respiratory paralysis!\nTaking benzodiazepines can cause numerous undesirable side effects. In addition, regular and long-term use carries a very high risk of physical and psychological dependence. Benzodiazepines should only be taken as prescribed by a doctor and only for a short period of time (max. 4-6 weeks). Longer-term use should be discussed with the treating specialist. The dosages and duration of action of the individual benzodiazepines differ considerably.\nSide effects of benzodiazepines may be as follows: Prolonged fatigue, gastrointestinal problems, impaired reactions, hypersensitivity reactions, headaches, dizziness, motor difficulties, visual disturbances, slowed breathing, muscle weakness, confusion, sexual dysfunction, aggression, outbursts of anger, restlessness, random movements, allergies, skin problems/rashes and speech and movement disorders. Some benzodiazepines can cause seizures in epileptics.", "longtermRisks": "Regular and long-term use can lead to psychological and physical dependence (very high dependence potential). Immediate discontinuation of the drug after prolonged use can lead to negative withdrawal symptoms (including dizziness, physical weakness, inner restlessness, tremors, sleep disturbances, headaches, sweating, nausea, hallucinations and depression).\nIn addition, seizures and memory disorders/loss and listlessness (hangover effects) can occur. In case of possible dependence, withdrawal should be discussed with a doctor beforehand and the withdrawal should be medically accompanied. It is extremely important that the dose is reduced gradually.", "saferUse": [ "If medicines are obtained on the black market or on the internet and not from a pharmacy/medical facility, the contents are unclear. Have the medicine tested for the exact ingredients in a drug check!", "Do not rely on dosage information from colleagues who regularly use benzodiazepines. Due to habituation or dependence, their doses can be much higher and fatal for new users.", "Blisters of counterfeits may look identical to the original packaging.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, opioids and/or other benzodiazepines is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!" ], "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.05, "commonMin": 0.3, "strongMin": 0.5, "heavyMin": 1 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 2, "max": 6, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "Flubromazepam", "commonNames": [ "Flubromazepam" ], "url": "https://psychonautwiki.org/wiki/Flubromazepam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "research-chemical", "habit-forming" ], "summary": "A somewhat common benzodiazepine drug known for its extreme duration, with effects for larger doses reaching up to three days. Sedative, hypnotic and anxiolytic, this compound is an analogue of Phenazepam. First discovered in the 1960s, it was never marketed as a licit drug, but has recently become available as an RC. Not to be confused with Flubromazolam.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 5, "strongMin": 8, "heavyMin": 12 }, "duration": { "onset": { "min": 40, "max": 90, "units": "minutes" }, "total": { "min": 6, "max": 12, "units": "hours" } } } ] }, { "name": "Flubromazolam", "commonNames": [ "Flubromazolam" ], "url": "https://psychonautwiki.org/wiki/Flubromazolam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "research-chemical", "habit-forming" ], "summary": "A very potent benzodiazepine derivative that is related to Triazolam and Pyrazolam. Popular in the research chemical scene, it is a potent sedative, hypnotic and anxiolytic. Potential for amnesia and reduced inhibitions in higher dose. Not to be confused with Flubromazepam, which is much less potent and has a much longer half-life.", "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 50, "commonMin": 150, "strongMin": 250, "heavyMin": 400 }, "duration": { "total": { "min": 12, "max": 18, "units": "hours" } } } ] }, { "name": "Flunitrazepam", "commonNames": [ "Rohypnol", "Flunitrazepam", "Roofies", "Roches", "Ruffies", "Circles", "Forget Pill", "Forget Me Pill", "La Rocha", "Mexican Valium", "R2", "Roach 2", "Rophies", "Wolfies" ], "url": "https://psychonautwiki.org/wiki/Flunitrazepam", "isApproved": false, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "habit-forming" ], "summary": "Known as Rohypnol or 'roofies,' this infamous drug has similar qualities to most other benzodiazepines; sedating with strong hypnotic effects. Despite being known as a 'date rape drug' has only been implicated in a small number of such crimes. Danger of respiratory depression in combination with other depressants. May cause amnesia and lowered inhibitions in overdose.", "effectsSummary": "Flunitrazepam has a calming, relaxing, antispasmodic, anti-anxiety and sleep-inducing effect.\nTaking benzodiazepines increases the effectiveness of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This triggers sedative (calming), hypnotic, anxiolytic (anxiety-relieving), anticonvulsant (anticonvulsant) and muscle-relaxing effects in the body. Benzodiazepines have a depressant effect on the central nervous system. The flow of information in the brain between the brain cells (neurons) is thereby reduced / disturbed and feelings and perceptions are dampened.\nThe breakdown of the individual active ingredients of benzodiazepines in the body is age-dependent and therefore varies from person to person.", "generalRisks": "There is little information available on risks, toxicity, side effects and long-term consequences. Therefore, the general information on benzodiazepines applies:\nWhen mixing with other downers (alcohol, GHB/GBL, heroin) there is a risk of respiratory paralysis!\nTaking benzodiazepines can cause numerous undesirable side effects. In addition, regular and long-term use carries a very high risk of physical and psychological dependence. Benzodiazepines should only be taken as prescribed by a doctor and only for a short period of time (max. 4-6 weeks). Longer-term use should be discussed with the treating specialist. The dosages and duration of action of the individual benzodiazepines differ considerably.\nSide effects of benzodiazepines may be as follows: Prolonged fatigue, gastrointestinal problems, impaired reactions, hypersensitivity reactions, headaches, dizziness, motor difficulties, visual disturbances, slowed breathing, muscle weakness, confusion, sexual dysfunction, aggression, outbursts of anger, restlessness, random movements, allergies, skin problems/rashes and speech and movement disorders. Some benzodiazepines can cause seizures in epileptics.", "longtermRisks": "Regular and long-term use can lead to psychological and physical dependence (very high dependence potential). Immediate discontinuation of the drug after prolonged use can lead to negative withdrawal symptoms (including dizziness, physical weakness, inner restlessness, tremors, sleep disturbances, headaches, sweating, nausea, hallucinations and depression).\nIn addition, seizures and memory disorders/loss and listlessness (hangover effects) can occur. In case of possible dependence, withdrawal should be discussed with a doctor beforehand and the withdrawal should be medically accompanied. It is extremely important that the dose is reduced gradually.", "saferUse": [ "If medicines are obtained on the black market or on the internet and not from a pharmacy/medical facility, the contents are unclear. Have the medicine tested for the exact ingredients in a drug check!", "Do not rely on dosage information from colleagues who regularly use benzodiazepines. Due to habituation or dependence, their doses can be much higher and fatal for new users.", "Blisters of counterfeits may look identical to the original packaging.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, opioids and/or other benzodiazepines is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.2, "commonMin": 1, "strongMin": 3, "heavyMin": 4 }, "duration": { "onset": { "min": 20, "max": 30, "units": "minutes" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 2, "max": 24, "units": "hours" } } } ] }, { "name": "Flunitrazolam", "commonNames": [ "Flunitrazolam" ], "url": "https://psychonautwiki.org/wiki/Flunitrazolam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "habit-forming", "tentative" ], "summary": "A very potent hypnotic Benzodiazepine. Triazolo version of Flunitrazepam.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.1, "commonMin": 0.2, "strongMin": 0.3, "heavyMin": 0.5 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 1, "max": 12, "units": "hours" } } } ] }, { "name": "Gabapentin", "commonNames": [ "Gabapentin", "Neurontin", "Gabarone", "Gralise" ], "url": "https://psychonautwiki.org/wiki/Gabapentin", "isApproved": true, "tolerance": { "full": "with prolonged continuous usage", "zero": "7-14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [], "toxicities": [ "low toxicity" ], "categories": [ "depressant", "habit-forming" ], "summary": "An analogue of GABA also known as Neurontin, originally developed to treat epilepsy. Commonly prescribed for neuropathic pain, it also has pronounced anxiolytic effects leading to its use in treating anxiety disorders.", "interactions": { "dangerous": [ "Opioids", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 200, "commonMin": 900, "strongMin": 1500, "heavyMin": 2400 }, "duration": { "onset": { "min": 30, "max": 120, "units": "minutes" }, "peak": { "min": 120, "max": 180, "units": "minutes" }, "total": { "min": 6, "max": 10, "units": "hours" } }, "bioavailability": { "min": 27, "max": 60 } } ] }, { "name": "Gaboxadol", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Gaboxadol", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [ "hallucinogen", "depressant" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 30, "heavyMin": 45 }, "duration": { "onset": { "min": 15, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 3, "units": "minutes" }, "total": { "min": 2, "max": 5, "units": "minutes" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } } ] }, { "name": "Galantamine", "commonNames": [ "Galantamine" ], "url": "https://psychonautwiki.org/wiki/Galantamine", "isApproved": true, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "extremely low toxicity" ], "categories": [ "oneirogen", "nootropic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 8, "strongMin": 16, "heavyMin": 24 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "total": { "min": 6, "max": 12, "units": "hours" } }, "bioavailability": { "max": 90 } } ] }, { "name": "GBL", "commonNames": [ "GBL", "gamma-Butyrolactone" ], "url": "https://psychonautwiki.org/wiki/GBL", "isApproved": true, "tolerance": { "full": "within several days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [], "addictionPotential": "highly physically and moderately to highly psychologically addictive", "toxicities": [], "categories": [ "depressant", "habit-forming", "common" ], "summary": "A pro-drug to GHB whose rapid absorption leads it to have a faster onset and shorter duration. Used in a similar manner to GHB, as a less-toxic alternative to alcohol. Consume slowly instead of as a \"shot\" to hugely improve safety and reduce overdose risk.", "effectsSummary": "The effect is extremely dose-dependent and varies greatly from individual to individual. It also depends on the purity of the substance. The spectrum of effects ranges from euphoria, relaxation, disinhibition, intensification of perception, urge to talk (babble flash), slight dizziness and drowsiness to deep (coma-like) sleep or unconsciousness.", "dosageRemark": "The dosage depends on the degree of dilution and is even more delicate with GBL than with GHB, as not every body converts GBL into GHB at the same rate and in the same amount. GBL is a strong acid that can corrode the mucous membranes and must be heavily diluted with a non-alcoholic drink before drinking! In case of doubt: less is more!", "generalRisks": "The higher the dose, the more likely nausea, vomiting and dizziness will occur. Headaches, confusion, breathing difficulties, cardiac arrhythmias, impaired balance and memory can occur at very high doses, as can uncontrollable muscle twitching, which is easily mistaken for epilepsy but can also progress into epilepsy.\nThe danger of an unintentional overdose is very high with GBL - even if it is not mixed! Signs of a GBL overdose are severe drowsiness followed by several hours of deep sleep that cannot be disturbed or can only be disturbed with difficulty (sometimes interrupted by short periods of wakefulness = standing man symptom), mild to very severe nausea, nausea, dizziness, headache, muscle atrophy (barely able to stay on one's feet) up to complete immobility, unconsciousness, disappearance of reflexes and breathing difficulties. It is difficult to assess whether users are only in a deep sleep or already in a coma after GBL use - if in doubt, always seek medical help!", "longtermRisks": "Regular use of GBL can lead to sleep disorders, anxiety and tremors; there is a risk of dependence with psychological and physical symptoms. In the case of chronic high-dose consumption (several doses daily), severe physical withdrawal symptoms such as sweating, muscle cramps or epileptic seizures occur upon discontinuation.", "saferUse": [ "If you are offered GBL, ask about the origin of the substance and the dosage.", "GBL should be dosed lower than GHB! To produce the same effect, you need about half as much GBL as GHB.", "Dose carefully! If GBL does not (yet) work, it is best to wait 2 hours and not add more right away. Often, overdosing is caused by adding more. Use an insulin syringe or graduated pipettes so that you can measure your unit of consumption accurately. Make a note of when you took your last dose.", "Refrain from using GBL when you are alone.", "With GBL, refrain from mixed consumption of any kind, especially with alcohol! Dilute the liquid before consumption, e.g. with tea.", "If you have sex on GBL, follow the safe sex rules. Have condoms etc. ready before consumption.", "People with epilepsy, heart or kidney dysfunction should not consume GBL under any circumstances!", "GBL withdrawal should only be carried out under medical supervision.", "Never leave your drink unattended to avoid someone mixing GBL into your drink. If your drink tastes strange, pour it out for your own safety." ], "interactions": { "dangerous": [ "Ketamine", "Methoxetamine", "Dextromethorphan", "PCP", "Alcohol", "Opioids", "Tramadol", "Benzodiazepines" ], "unsafe": [], "uncertain": [ "Nitrous", "Substituted amphetamines", "MDMA", "Cocaine" ] }, "roas": [ { "name": "oral", "dose": { "units": "mL", "lightMin": 0.3, "commonMin": 0.9, "strongMin": 1.5, "heavyMin": 3 }, "duration": { "onset": { "min": 3, "max": 10, "units": "minutes" }, "comeup": { "min": 5, "max": 15, "units": "minutes" }, "peak": { "min": 30, "max": 45, "units": "minutes" }, "offset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 1, "max": 2, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } } ] }, { "name": "GHB", "commonNames": [ "GHB", "G", "Xyrem", "Sodium oxybate" ], "url": "https://psychonautwiki.org/wiki/GHB", "isApproved": true, "tolerance": { "full": "within several days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [], "addictionPotential": "moderately to highly physically and moderately psychologically addictive", "toxicities": [ "considered to be a safe and non-toxic substance when used responsibly or medically", "Doses above 10 grams are associated with a risk of death" ], "categories": [ "depressant", "habit-forming", "common" ], "summary": "A euphoric depressant which is prescribed as a sleep aid and sometimes to help with Alcohol detox. Also used as a recreational depressant, as a non-toxic alternative to Alcohol. Despite not having Alcohol's toxicity it is risky due to among other things inconsistent concentration in commonly sold solution form, and can be very dangerous if taken with other depressants.", "effectsSummary": "The effect is extremely dose-dependent and varies greatly from individual to individual. It also depends on the purity of the substance. The spectrum of effects ranges from euphoria, relaxation, disinhibition, intensification of perception, urge to talk (babble flash), slight dizziness and drowsiness to deep (coma-like) sleep or unconsciousness.", "generalRisks": "The higher the dose, the more likely nausea, vomiting and dizziness will occur. Headaches, confusion, breathing difficulties, cardiac arrhythmias, impaired balance and memory can occur at very high doses, as can uncontrollable muscle twitching, which is easily mistaken for epilepsy but can also progress into epilepsy.\nThe danger of an unintentional overdose is very high with GHB - even if it is not mixed! Signs of a GHB overdose are severe drowsiness followed by several hours of deep sleep that cannot be disturbed or can only be disturbed with difficulty (sometimes interrupted by short periods of wakefulness = standing man symptom), mild to very severe nausea, nausea, dizziness, headache, muscle atrophy (barely able to stay on one's feet) up to complete immobility, unconsciousness, disappearance of reflexes and breathing difficulties. It is difficult to assess whether users are only in a deep sleep or already in a coma after GHB use - if in doubt, always seek medical help!", "longtermRisks": "Regular use of GHB/GBL can lead to sleep disorders, anxiety and tremors; there is a risk of dependence with psychological and physical symptoms. In the case of chronic high-dose consumption (several doses daily), severe physical withdrawal symptoms such as sweating, muscle cramps or epileptic seizures occur upon discontinuation.", "saferUse": [ "If you are offered GHB, ask about the origin of the substance and the dosage.", "Dose carefully! If GHB does not (yet) work, it is best to wait 2 hours and not add more right away. Often, overdosing is caused by adding more. Use an insulin syringe or graduated pipettes so that you can measure your unit of consumption accurately. Make a note of when you took your last dose.", "Refrain from using GHB when you are alone.", "With GHB, refrain from mixed consumption of any kind, especially with alcohol! Dilute the liquid before consumption, e.g. with tea.", "If you have sex on GHB, follow the safe sex rules. Have condoms etc. ready before consumption.", "People with epilepsy, heart or kidney dysfunction should not consume GHB under any circumstances!", "GHB withdrawal should only be carried out under medical supervision.", "Never leave your drink unattended to avoid someone mixing GHB into your drink. If your drink tastes strange, pour it out for your own safety." ], "interactions": { "dangerous": [ "Ketamine", "Methoxetamine", "Dextromethorphan", "PCP", "Alcohol", "Opioids", "Tramadol", "Benzodiazepines" ], "unsafe": [], "uncertain": [ "Nitrous", "Substituted amphetamines", "MDMA", "Cocaine" ] }, "roas": [ { "name": "oral", "dose": { "units": "g", "lightMin": 0.5, "commonMin": 1, "strongMin": 2.5, "heavyMin": 4 }, "duration": { "onset": { "min": 5, "max": 30, "units": "minutes" }, "comeup": { "min": 10, "max": 20, "units": "minutes" }, "peak": { "min": 45, "max": 90, "units": "minutes" }, "offset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 1.5, "max": 2.5, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "Glaucine", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Glaucine", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [ "psychedelic", "depressant", "opioid", "habit-forming", "tentative" ], "summary": "An alkaloid that is found in several different scpecies in the Papaveraceae family. It has antiinflammatory and antitussive effects. Can also be referred to as Yellow Horned Poppy.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 75, "strongMin": 150, "heavyMin": 180 }, "duration": { "onset": { "min": 20, "max": 45, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 3, "max": 8, "units": "hours" } }, "bioavailability": { "min": 17 } } ] }, { "name": "Haloperidol", "commonNames": [ "Haldol" ], "url": "https://psychonautwiki.org/wiki/Haloperidol", "isApproved": true, "crossTolerances": [], "toxicities": [ "can have serious side effects at higher dosages", "risk of having severe extrapyramidal symptoms and muscle rigidity" ], "categories": [ "antipsychotic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.25, "commonMin": 1, "strongMin": 5, "heavyMin": 10 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 12, "max": 36, "units": "hours" } } } ] }, { "name": "Heroin", "commonNames": [ "Heroin", "H", "Smack", "Junk", "Brown" ], "url": "https://psychonautwiki.org/wiki/Heroin", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "extremely addictive with a high potential for abuse", "toxicities": [], "categories": [ "opioid", "habit-forming", "depressant", "common" ], "summary": "A powerful opioid derived from Morphine, with 2-4x its potency. Infamous for a high addiction potential and fatal respiratory depression in overdose, C. R. Alder Wright first synthesised this compound in 1874 trying to find a less addictive alternative to Morphine. In recent years, it has often been sold cut with the extremely potent fentanyl, causing a spike in overdose deaths.", "effectsSummary": "Pain-relieving, balancing, calming, anxiety-relieving and euphoric. The euphoric \"flash\" at the beginning is followed by a state of well-being and a feeling of indifference, serenity, light-heartedness and self-satisfaction.", "dosageRemark": "The dose depends on the individual tolerance to heroin. The lethal dose in non-tolerant people is about 60 mg.", "generalRisks": "Slowing of breathing, nausea, vomiting, itching, drop in blood pressure, pulse slowing, pupil constriction and urinary retention may occur.\nOther side effects of regular use of heroin: confusion, disorientation, memory lapses, slurred and garbled speech as well as coordination disorders, extreme constipation, reduction of sexual desire and a potentially life-threatening reduction of the breathing rate to 2 to 4 breaths per minute (due to the attenuation of the coughing and breathing centre).\nHigh doses of heroin can be fatal if medical help is not sought immediately!\nThe drug methadone is a synthetic opioid and is used as a substitute for heroin addiction. For users who are not used to opiates, the consumption of methadone even in small quantities can be life-threatening (severe respiratory depression, danger of suffocation).\nSniffing: damage to nasal septums and mucous membranes. Risk of hepatitis C infection.\nSmoking: damage to bronchial tubes and lungs (lungs become sticky with daily use).\nInjections: Venous inflammation and risk of infectious diseases (hepatitis C, HIV/AIDS, fungi). Organ damage can occur due to the impurities in heroin.", "longtermRisks": "The risk of dependence with psychological and physical symptoms is great. As soon as a tolerance has developed and the body is not supplied with the necessary amount of substance, physical withdrawal symptoms occur 8 to 12 hours after the last heroin intake. Withdrawal symptoms are sweating and chills, running eyes and nose, vomiting, diarrhoea, restlessness, irritability, weakness, anxiety, depressive states, painful cramps, insomnia and, less frequently, hallucinations, psychotic phases and seizures.", "saferUse": [ "Always use your own clean and new spraying equipment (needles, filters, spoons).", "Follow the safe sniffing rules when sniffing.", "Avoid mixed use with other substances, otherwise the effect becomes incalculable and the risks increase! Note that the combination with other downers (e.g. benzodiazepines) can lead to respiratory arrest.", "The risk of overdose is particularly high after longer periods of non-use and with extremely \"pure substance\".", "Consume in a quiet environment and not alone." ], "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 35, "heavyMin": 50 }, "duration": { "onset": { "min": 10, "max": 60, "units": "seconds" }, "comeup": { "min": 10, "max": 60, "units": "seconds" }, "peak": { "min": 1, "max": 90, "units": "minutes" }, "offset": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 3, "max": 7, "units": "hours" }, "afterglow": { "min": 1.5, "max": 3, "units": "hours" } } }, { "name": "intravenous", "dose": { "units": "mg", "commonMin": 5, "strongMin": 8, "heavyMin": 15 }, "duration": { "onset": { "min": 0, "max": 5, "units": "seconds" }, "comeup": { "min": 0, "max": 5, "units": "seconds" }, "peak": { "min": 1, "max": 4, "units": "hours" }, "offset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 4, "max": 5, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 2, "commonMin": 15, "strongMin": 25, "heavyMin": 50 }, "duration": { "onset": { "min": 5, "max": 10, "units": "seconds" }, "comeup": { "min": 5, "max": 10, "units": "seconds" }, "peak": { "min": 15, "max": 30, "units": "minutes" }, "offset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 3, "max": 5, "units": "hours" }, "afterglow": { "min": 10, "max": 30, "units": "minutes" } } } ] }, { "name": "Hexedrone", "commonNames": [ "Hexedrone" ], "url": "https://psychonautwiki.org/wiki/Hexedrone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [], "categories": [ "stimulant", "research-chemical", "tentative", "habit-forming" ], "summary": "A rare mephedrone analogue also known as MACP, a cathinone stimulant with similar effects to pentedrone.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 30, "commonMin": 70, "strongMin": 100, "heavyMin": 125 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 1, "max": 4, "units": "hours" }, "afterglow": { "min": 1, "max": 12, "units": "hours" } } } ] }, { "name": "HXE", "commonNames": [ "HXE" ], "url": "https://psychonautwiki.org/wiki/HXE", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [], "categories": [ "dissociative" ], "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 20, "commonMin": 40, "strongMin": 70, "heavyMin": 120 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1.5, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 7, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 30, "commonMin": 60, "strongMin": 100, "heavyMin": 130 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 3, "max": 6, "units": "hours" }, "total": { "min": 3, "max": 8, "units": "hours" }, "afterglow": { "min": 1, "max": 12, "units": "hours" } } }, { "name": "sublingual", "dose": { "units": "mg", "lightMin": 30, "commonMin": 60, "strongMin": 100, "heavyMin": 130 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 6, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 1, "max": 12, "units": "hours" } } } ] }, { "name": "Hydrocodone", "commonNames": [ "Vicodin (with paracetamol)", "Zohydro ER (extended-release)" ], "url": "https://psychonautwiki.org/wiki/Hydrocodone", "isApproved": true, "tolerance": { "full": "with prolonged use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "moderately addictive", "toxicities": [ "potentially fatal at heavy dosages" ], "categories": [ "opioid", "depressant", "habit-forming", "common" ], "summary": "A codeine-derived opioid generally unheard of outside the United States. Generally mild in effects, used as an analgesic and cough-supressant. Sometimes used recreationally.", "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 10, "strongMin": 25, "heavyMin": 40 }, "duration": { "onset": { "min": 10, "max": 60, "units": "minutes" }, "total": { "min": 4, "max": 8, "units": "hours" } } } ] }, { "name": "Hydromorphone", "commonNames": [ "Dilaudid", "Jurnista", "Palladone" ], "url": "https://psychonautwiki.org/wiki/Hydromorphone", "isApproved": true, "crossTolerances": [ "opioids" ], "toxicities": [], "categories": [ "opioid", "habit-forming", "depressant" ], "summary": "An opioid that is roughly 5x the potency of IV Morphine. Only comes in IR tablets in the US, and is given mostly as XR in other countries. It is frequently used in hospitals for short, but immediate pain relief during procedures requiring the patient to be awake. Also frequently used as a recreational opiate.", "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "intravenous", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 2, "strongMin": 4, "heavyMin": 6 }, "duration": { "onset": { "min": 10, "max": 90, "units": "seconds" }, "peak": { "min": 1, "max": 2, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 2, "strongMin": 4, "heavyMin": 8 }, "duration": { "onset": { "min": 20, "max": 45, "units": "minutes" }, "peak": { "min": 3, "max": 4, "units": "hours" } } } ] }, { "name": "Ibogaine", "commonNames": [ "Ibogaine", "Endabuse", "Iboga" ], "url": "https://psychonautwiki.org/wiki/Ibogaine", "isApproved": true, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [], "categories": [ "psychedelic", "opioid", "dissociative", "depressant" ], "summary": "An alkaloid found in many African plants most famously Iboga, with psychedelic and hallucinogenic properties. May be unpleasant. Traditionally used in tribal environments for coming-of-age rituals, it has recently been used as an alternative treatment for drug addiction although this usage has not been backed by conclusive data in humans. Has killed in overdose.", "roas": [ { "name": "oral", "dose": { "units": "mg/kg of body weight", "commonMin": 15, "strongMin": 22 }, "duration": { "onset": { "min": 30, "max": 180, "units": "minutes" }, "peak": { "min": 18, "max": 36, "units": "hours" }, "afterglow": { "min": 24, "max": 72, "units": "hours" } } } ] }, { "name": "Isopropylphenidate", "commonNames": [ "Isopropylphenidate", "IPH", "IPPH" ], "url": "https://psychonautwiki.org/wiki/Isopropylphenidate", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "research-chemical", "habit-forming", "tentative" ], "summary": "IPPH (or incorrectly IPH) is a novel piperidine based methylphenidate analogue and NDRI stimulant, but comes with much less physical side effects.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 2, "commonMin": 10, "strongMin": 20, "heavyMin": 35 }, "duration": { "onset": { "min": 2, "max": 5, "units": "minutes" }, "comeup": { "min": 10, "max": 30, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 2.5, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 15, "strongMin": 25, "heavyMin": 45 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 3.5, "max": 6, "units": "hours" } } } ] }, { "name": "JWH-018", "commonNames": [], "url": "https://psychonautwiki.org/wiki/JWH-018", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "cannabinoids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "cannabinoid" ], "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "2C-T-x", "2C-x", "5-MeO-xxT", "Substituted amphetamines", "ΑMT", "Cocaine", "DMT", "DOx", "LSD", "Mescaline", "Psilocybin mushrooms", "25x-NBOMe" ] }, "roas": [ { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 2, "strongMin": 3, "heavyMin": 5 }, "duration": { "onset": { "min": 5, "max": 10, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 5, "max": 10, "units": "minutes" }, "total": { "min": 1, "max": 2, "units": "hours" }, "afterglow": { "min": 60, "max": 90, "units": "minutes" } } } ] }, { "name": "JWH-073", "commonNames": [ "JWH-073", "Spice" ], "url": "https://psychonautwiki.org/wiki/JWH-073", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "cannabinoids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [], "categories": [ "cannabinoid" ], "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "2C-T-x", "2C-x", "5-MeO-xxT", "Substituted amphetamines", "ΑMT", "Cocaine", "DMT", "DOx", "LSD", "Mescaline", "Psilocybin mushrooms", "25x-NBOMe" ] }, "roas": [ { "name": "smoked", "dose": { "units": "mg", "lightMin": 3, "commonMin": 5, "strongMin": 10, "heavyMin": 15 }, "duration": { "onset": { "min": 5, "max": 10, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 5, "max": 10, "units": "minutes" }, "total": { "min": 1, "max": 2, "units": "hours" }, "afterglow": { "min": 60, "max": 90, "units": "minutes" } } } ] }, { "name": "Kava", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Kava", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [ "depressant", "habit-forming" ], "summary": "Tropical evergreen shrub with large heart-shaped leaves and woody stems. Its thick roots are mashed or ground and made into a cold and bitter-tasting beverage used similarly to alcohol. It has a long history of ritual and recreational use in Pacific Polynesia and is now a common herbal product, used widely by those in certain societies as part of a 'Kava Culture.'", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [] }, { "name": "Ketamine", "commonNames": [ "Ketamine", "K", "Ket", "Kitty", "Special K", "Cat Tranquilizer", "Ketaset", "Ketalar", "Ketanest", "Vitamin K", "Purple", "Jet" ], "url": "https://psychonautwiki.org/wiki/Ketamine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderate to high abuse potential and produces psychological dependence with chronic use", "toxicities": [], "categories": [ "dissociative", "habit-forming", "common" ], "summary": "A short acting dissociative anaesthetic and hallucinogen commonly used in emergency medicine. It is the prototypical dissociative, and is widely used at sub-anesthetic doses recreationally. Small doses are comparable with alcohol, while larger doses are immobilising and lead to psychedelic experiences: the \"K-Hole.\"", "effectsSummary": "The effect of ketamine as an intoxicant is strongly dependent on the dosage: In lower doses, it has a disinhibiting and relaxing effect similar to alcohol, while higher doses can induce trance-like states up to out-of-body or near-death experiences (K-Hole). There can be a fragmentary dissolution of the environment and bodily sensation, thoughts can break off, feelings of weightlessness or floating can appear. Sensory perceptions and the sense of space-time change. At higher doses, detachment from one's own body and/or ego dissolution or merging with the environment may occur.\nAfter the trip: drowsiness, memory of the experience is often only partially possible.", "dosageRemark": "The dosage of ketamine depends strongly on the desired effect.", "generalRisks": "Movement and communication may be severely restricted. Partial or complete insensitivity to pain, coordination disorders, sensation of weakness, loss of appetite, nausea, vomiting, uncoordinated muscle movements, dizziness, slurred speech, increased pulse and blood pressure and cardiac arrhythmias. At high doses, muscle stiffness, paralysis and narcosis, at very high doses, epileptic seizures and coma.\nKetamine puts a strain on the cardiovascular system. A ketamine trip can be psychologically very stressful. Many ketamine users report near-death experiences, nightmare hallucinations, tunnel visions, blackouts and short periods of memory loss.\nAfter repeated consumption within a short period of time, the effect diminishes considerably and a tolerance develops.\nKetamine taken intravenously quicker than 1.5 minute can cause breathing depression for up to a minute.", "longtermRisks": "Ketamine can cause dependence with psychological symptoms. Chronic use damages the liver and kidneys and can lead to depressive moods and anxiety. It is suspected that even in small doses, ketamine can trigger dysfunctions in areas of the brain responsible for memory, learning and perception. The more often it is consumed and the larger the individual doses, the more alarming these disturbances become.", "saferUse": [ "Ketamine is not a party drug! Do not take ketamine alone and make sure you are in a familiar and comfortable environment. Allow enough time to process the trip in peace afterwards.", "Dose carefully. Small differences in dose can cause significant differences in effect, so dosing is difficult.", "Take regular breaks from consumption.", "You need a place to sit or lie down, because at high doses there is a great risk of collapsing or fainting.", "Because of the insensitivity to pain, you can hurt yourself without noticing it.", "Do not take ketamine on a full stomach.", "Refrain from mixed consumption. When combined with alcohol, benzodiazepines or opiates, there is a risk of respiratory arrest! Mixing with uppers (e.g. cocaine) can lead to circulatory problems, increase in heart rate and shortness of breath.", "People with cardiovascular problems, high blood pressure or glaucoma should absolutely refrain from consuming ketamine!" ], "interactions": { "dangerous": [ "Tramadol", "Alcohol", "GHB", "GBL", "Opioids" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "Cocaine", "Benzodiazepines", "MAOI", "Trazodone", "Grapefruit" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 30, "strongMin": 75, "heavyMin": 150 }, "duration": { "onset": { "min": 5, "max": 10, "units": "minutes" }, "comeup": { "min": 10, "max": 20, "units": "minutes" }, "peak": { "min": 15, "max": 45, "units": "minutes" }, "offset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 1, "max": 2, "units": "hours" }, "afterglow": { "min": 2, "max": 12, "units": "hours" } }, "bioavailability": { "max": 45 } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 100, "strongMin": 300, "heavyMin": 450 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "comeup": { "min": 5, "max": 20, "units": "minutes" }, "peak": { "min": 45, "max": 90, "units": "minutes" }, "offset": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 8, "units": "hours" } }, "bioavailability": { "max": 17 } }, { "name": "sublingual", "bioavailability": { "min": 20, "max": 29 } } ] }, { "name": "Kratom", "commonNames": [ "Mitragyna Speciosa", "กระท่อม (Thai)", "Ketum", "Kratom", "Kratum" ], "url": "https://psychonautwiki.org/wiki/Kratom", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "produces dependence with chronic use and has a high abuse potential", "toxicities": [ "low toxicity" ], "categories": [ "stimulant", "opioid", "habit-forming", "depressant", "common" ], "summary": "A drug made out of the leaves of Mitragyna Speciosa, which is related to coffee. Stimulating at lower doses, with opioid effects at higher doses. Frequent heavy use can cause physical addiction and withdrawals.", "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "g", "lightMin": 1, "commonMin": 3, "strongMin": 5, "heavyMin": 8 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 3, "max": 6, "units": "hours" }, "total": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "LAE-32", "commonNames": [], "url": "https://psychonautwiki.org/wiki/LAE-32", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "psychedelic" ], "interactions": { "dangerous": [], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Substituted amphetamines", "Cocaine" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "commonMin": 500, "strongMin": 1500 }, "duration": { "total": { "min": 4, "max": 10, "units": "hours" } } } ] }, { "name": "Lisdexamfetamine", "commonNames": [ "Lisdexamfetamine", "Vyvanse", "Elvanse" ], "url": "https://psychonautwiki.org/wiki/Lisdexamfetamine", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 30, "strongMin": 60, "heavyMin": 90 }, "duration": { "onset": { "min": 60, "max": 90, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 4, "max": 6, "units": "hours" }, "total": { "min": 10, "max": 14, "units": "hours" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "Lorazepam", "commonNames": [ "Lorazepam", "Ativan", "Orfidal", "Lorsilan" ], "url": "https://psychonautwiki.org/wiki/Lorazepam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "habit-forming", "common" ], "summary": "An intermediate acting benzodiazepine commonly known as Ativan, commonly prescribed as an alternative to Xanax. Sedating, hypnotic and anxiolytic. Potential to induce amnesia and lowered inhibitions in overdose. Do not combine with other depressants.", "effectsSummary": "Lorazepam has a calming, relaxing, antispasmodic, anti-anxiety and sleep-inducing effect.\nTaking benzodiazepines increases the effectiveness of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This triggers sedative (calming), hypnotic, anxiolytic (anxiety-relieving), anticonvulsant (anticonvulsant) and muscle-relaxing effects in the body. Benzodiazepines have a depressant effect on the central nervous system. The flow of information in the brain between the brain cells (neurons) is thereby reduced / disturbed and feelings and perceptions are dampened.\nThe breakdown of the individual active ingredients of benzodiazepines in the body is age-dependent and therefore varies from person to person.", "generalRisks": "There is little information available on risks, toxicity, side effects and long-term consequences. Therefore, the general information on benzodiazepines applies:\nWhen mixing with other downers (alcohol, GHB/GBL, heroin) there is a risk of respiratory paralysis!\nTaking benzodiazepines can cause numerous undesirable side effects. In addition, regular and long-term use carries a very high risk of physical and psychological dependence. Benzodiazepines should only be taken as prescribed by a doctor and only for a short period of time (max. 4-6 weeks). Longer-term use should be discussed with the treating specialist. The dosages and duration of action of the individual benzodiazepines differ considerably.\nSide effects of benzodiazepines may be as follows: Prolonged fatigue, gastrointestinal problems, impaired reactions, hypersensitivity reactions, headaches, dizziness, motor difficulties, visual disturbances, slowed breathing, muscle weakness, confusion, sexual dysfunction, aggression, outbursts of anger, restlessness, random movements, allergies, skin problems/rashes and speech and movement disorders. Some benzodiazepines can cause seizures in epileptics.", "longtermRisks": "Regular and long-term use can lead to psychological and physical dependence (very high dependence potential). Immediate discontinuation of the drug after prolonged use can lead to negative withdrawal symptoms (including dizziness, physical weakness, inner restlessness, tremors, sleep disturbances, headaches, sweating, nausea, hallucinations and depression).\nIn addition, seizures and memory disorders/loss and listlessness (hangover effects) can occur. In case of possible dependence, withdrawal should be discussed with a doctor beforehand and the withdrawal should be medically accompanied. It is extremely important that the dose is reduced gradually.", "saferUse": [ "If medicines are obtained on the black market or on the internet and not from a pharmacy/medical facility, the contents are unclear. Have the medicine tested for the exact ingredients in a drug check!", "Do not rely on dosage information from colleagues who regularly use benzodiazepines. Due to habituation or dependence, their doses can be much higher and fatal for new users.", "Blisters of counterfeits may look identical to the original packaging.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, opioids and/or other benzodiazepines is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.1, "commonMin": 0.5, "strongMin": 1.5, "heavyMin": 2 }, "duration": { "total": { "min": 4, "max": 8, "units": "hours" } } } ] }, { "name": "LSA", "commonNames": [ "LSA", "Ergine" ], "url": "https://psychonautwiki.org/wiki/LSA", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "zero": "7 days", "zeroToleranceInHours": 168 }, "crossTolerances": [], "addictionPotential": "non-addictive with a low abuse potential", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "common" ], "summary": "A chemical found in Morning Glory and Hawaiian Baby Woodrose seeds, which are often legally available. Has mental effects similar to LSD, although with almost no visual effects. It is famous for being very nauseating, and for causing excessive time dilation at higher doses.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "seeds", "lightMin": 20, "commonMin": 100, "strongMin": 250, "heavyMin": 400 } }, { "name": "sublingual", "dose": { "units": "seeds", "lightMin": 1, "commonMin": 5, "strongMin": 7, "heavyMin": 12 } } ] }, { "name": "LSD", "commonNames": [ "LSD", "LSD-25", "Lucy", "L", "Acid", "Cid", "Tabs", "Blotter" ], "url": "https://psychonautwiki.org/wiki/LSD", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "zero": "5 days", "zeroToleranceInHours": 120 }, "crossTolerances": [ "psychedelics" ], "addictionPotential": "non-addictive with a low abuse potential", "toxicities": [ "extremely low toxicity relative to dose" ], "categories": [ "psychedelic", "common" ], "summary": "LSD is a popular psychedelic with a relatively long history of use and research, and as such is known to be relatively safe despite its extremely high potency. It is the archetypical psychedelic to which all others are compared, and remains in popular usage.", "effectsSummary": "The effect is very much dependent on dose, set and setting. As a hallucinogen, LSD intensifies and alienates sensory perceptions and the sense of space-time. Mood and feelings can change abruptly. At higher doses, feelings of detachment from one's own body can occur. Especially in the initial phase of the trip, slight breathing difficulties, palpitations, sweating, altered blood pressure and nausea may occur.", "generalRisks": "The risks of LSD use are psychological and depend on the personality structure of the user. The perceptual changes during a trip can be so intense that inexperienced users in particular feel overwhelmed by the flood of impressions. This can lead to erroneous reactions, loss of orientation, panic, paranoia and badtrips/horror trips.\nThere is a risk - even with single use - that latent (hidden) mental disorders can be triggered. LSD does not lead to organ damage or genetic mutations and is not physically addictive.", "saferUse": [ "Take LSD only if you are well prepared, in an environment where you feel comfortable, and only with experienced friends (favourable setting).", "Only take LSD when you feel good mentally and physically (cheap set).", "You should not be afraid, but have enough respect for the LSD effect.", "Do not consume LSD on a full stomach, but eat something light before or during the high.", "Dose low. Don't throw it if it doesn't work right away!", "Let yourself go during the trip, don't try to fight the LSD effect.", "Dextrose can help against circulatory problems.", "Avoid roads and other \"dangerous\" places, your orientation may be disturbed.", "At least the day after the trip, allow yourself plenty of rest and recovery to be able to process the experience.", "LSD trips should remain exceptional experiences and should in no case be experienced more than once a month.", "People with mental problems or illnesses, people taking neuroleptics and people with circulatory and heart problems should refrain from consuming LSD.", "Blotters: Orally administering (swallowing) substances whose identity is uncertain is a potential way to eliminate most of the effects from dangerous mimics like 25x-NBx (25x-NBOMe like 25I-NBOMe, and 25x-NBOH like 25I-NBOH, etc). 25I-NBOMe is widely rumored to be orally inactive; however, oral efficacy has not been disproven and apparent overdoses have occurred via oral administration. 25I-NBOMe (and other NB's like 25x-NBOMe, 25x-NBOH) have much lower oral bioavailability than sublingual, buccal, and sublabial administration. 25I-NBOMe, to which several deaths have been attributed may commonly be mistaken for LSD by sellers and users." ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol", "Deliriant", "Tricyclic antidepressants", "Ritonavir" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "sublingual", "dose": { "units": "µg", "lightMin": 15, "commonMin": 75, "strongMin": 150, "heavyMin": 300 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 3, "max": 5, "units": "hours" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 12, "max": 48, "units": "hours" } }, "bioavailability": { "min": 71, "max": 71 } } ] }, { "name": "LSM-775", "commonNames": [ "LSM-775" ], "url": "https://psychonautwiki.org/wiki/LSM-775", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelics" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical", "tentative" ], "summary": "Psychedelic of the lysergamide class, less potent by weight and produces a rather mild, dreamy and even sedating trip compared to its bigger brother LSD.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 250, "commonMin": 750, "strongMin": 1250, "heavyMin": 1500 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "total": { "min": 6, "max": 10, "units": "hours" } } } ] }, { "name": "LSZ", "commonNames": [ "LSZ", "LA-SS-Az", "Diazedine", "Lambda" ], "url": "https://psychonautwiki.org/wiki/LSZ", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A lysergamide very similar to LSD usually distinguishable only by its shorter duration, though some subjective reports have noted it may be slightly more introspective and slightly less confusing.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 50, "commonMin": 150, "strongMin": 300, "heavyMin": 400 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "Mandragora", "commonNames": [ "Mandrake" ], "url": "https://psychonautwiki.org/wiki/Mandragora", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [], "roas": [] }, { "name": "MCPP", "commonNames": [ "mCPP" ], "url": "https://psychonautwiki.org/wiki/MCPP", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant", "research-chemical", "tentative" ], "summary": "A phenylpiperazine stimulant first developed in the 1970s before being sold in the RC market, often mislabelled as MDMA. Said to have very unpleasant effects such as anxiogenesis and headaches.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "SNRIs", "Cocaine", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 15, "commonMin": 50, "strongMin": 120, "heavyMin": 150 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 3, "max": 8, "units": "hours" } } } ] }, { "name": "MDA", "commonNames": [ "MDA", "Sass", "Sally", "Tenamfetamine" ], "url": "https://psychonautwiki.org/wiki/MDA", "isApproved": true, "tolerance": { "full": "repeated and heavy usage", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [], "categories": [ "psychedelic", "entactogen", "stimulant", "habit-forming", "common" ], "summary": "A stimulant and empathogen. Similar to MDMA but typically produces more visuals than MDMA. Known to be more neurotoxic than MDMA, and is a minor metabolite of MDMA. Duration and onset similar to MDMA. The common Marquis reagent test cannot differentiate MDA and MDMA.", "effectsSummary": "MDA is closely related to MDMA. It differs mainly in how well one's own feelings are perceived (entactogenic effect), how strong empathic understanding (empathic effect) and hallucinogenic effects occur.", "dosageRemark": "1.3 mg per kg body weight (1.3 mg x 80 kg = 100 mg)", "generalRisks": "Nausea to nausea, dry mouth, cramping of the jaw muscles, sweating, coordination disorders, sleep disorders and trembling.", "longtermRisks": "MDA is both neurotoxic (damaging to the nerves) and hepatotoxic (damaging to the liver); regular use can lead to schizophrenia-like symptoms.", "saferUse": [ "First test a third or half a pill.", "Wait two hours for the effect to take effect before adding more.", "With MDA, topping up is pointless, as it is effective for a long time even in small doses.", "Refrain from mixed consumption.", "Avoid alcohol, drink enough non-alcoholic beverages (0.3-0.5 L per hour).", "Take breaks from dancing at parties and get some fresh air in between.", "Take regular breaks from consumption. The body needs time to recover.", "People taking medication are advised to inform themselves about interactions." ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 60, "strongMin": 100, "heavyMin": 145 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "comeup": { "min": 15, "max": 45, "units": "minutes" }, "peak": { "min": 2.5, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } } ] }, { "name": "MDAI", "commonNames": [ "MDAI" ], "url": "https://psychonautwiki.org/wiki/MDAI", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "entactogens" ], "addictionPotential": "somewhat habit-forming with a low potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "psychedelic", "stimulant", "research-chemical", "habit-forming" ], "summary": "A selective serotonin releasing agent which is rarely used without a stimulant to obtain desirable effects. Previously believed not to be neuruotoxic, however MDAI has been implicated in several lethal and non-lethal intoxications, and as such may pose more of a risk to health than previously believed.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 40, "commonMin": 100, "strongMin": 175, "heavyMin": 300 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" } } } ] }, { "name": "MDEA", "commonNames": [ "MDEA", "MDE", "Eve" ], "url": "https://psychonautwiki.org/wiki/MDEA", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "1-1.5 months", "zero": "2-3 months", "halfToleranceInHours": 900, "zeroToleranceInHours": 1800 }, "crossTolerances": [ "dopamine", "serotonin|serotonergic", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "tentative" ], "summary": "A quite rare empathogen closely related to MDMA. Yet is less potent than the prior.", "effectsSummary": "MDEA is closely related to MDMA. It differs mainly in how well one's own feelings are perceived (entactogenic effect), how strong empathic understanding (empathic effect) and hallucinogenic effects occur.", "dosageRemark": "1.3 mg per kg body weight (1.3 mg x 80 kg = 100 mg)", "generalRisks": "Nausea to nausea, dry mouth, cramping of the jaw muscles, sweating, coordination disorders, sleep disorders and trembling.", "longtermRisks": "MDA is both neurotoxic (damaging to the nerves) and hepatotoxic (damaging to the liver); regular use can lead to schizophrenia-like symptoms.", "saferUse": [ "First test a third or half a pill.", "Wait two hours for the effect to take effect before adding more.", "Refrain from mixed consumption.", "Avoid alcohol, drink enough non-alcoholic beverages (0.3-0.5 L per hour).", "Take breaks from dancing at parties and get some fresh air in between.", "Take regular breaks from consumption. The body needs time to recover.", "People taking medication are advised to inform themselves about interactions." ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "SNRIs", "Stimulants", "Cocaine", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 40, "commonMin": 120, "strongMin": 180, "heavyMin": 225 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 1.5, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 12, "max": 48, "units": "hours" } } } ] }, { "name": "MDMA", "commonNames": [ "MDMA", "Molly", "Mandy", "Emma", "MD", "Ecstasy", "E", "X", "XTC", "Rolls", "Beans", "Pingers" ], "url": "https://psychonautwiki.org/wiki/MDMA", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "1 month", "zero": "2.5 months", "halfToleranceInHours": 720, "zeroToleranceInHours": 1800 }, "crossTolerances": [ "dopaminergic", "serotonergic", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "psychedelic", "habit-forming", "common" ], "summary": "The world's most popular empathogen with powerful pro-social effects. Has been strongly linked to cognitive decline in excess. Popular at parties, it is often sold in powder or in pills, and may be adulterated with other similar chemicals.", "effectsSummary": "MDMA mainly causes an increased release of the body's own messenger substance serotonin. At the recommended dosage, about 80% of the available serotonin at that time is released. This release triggers a feeling of euphoria, lightness and light-heartedness. Sight and hearing change, touch and music are felt more intensely, inhibitions are reduced and the need for contact is increased. The effect is described as empathogenic (triggering a feeling of closeness and connection to other people) and entactogenic (touching the inner self, intensifying emotional perception). The simultaneous release of the neurotransmitters noradrenalin and dopamine has a stimulating effect. This reduces the feeling of hunger and thirst as well as tiredness and increases alertness. Body temperature and blood pressure also rise.", "dosageRemark": "Swallowed max. 1.5 mg MDMA per kg body weight for men, max. 1.3 mg per kg body weight for women. Lower doses are recommended for rectal and nasal use.", "generalRisks": "Side effects are jaw spasms, muscle tremors, urinary retention, headache, nausea/vomiting, increased pulse and blood pressure. The heart, liver and kidneys are particularly stressed. There is also a risk of life-threatening overheating as body temperature rises and the body becomes dehydrated. In the case of an overdose, hallucinations are possible. When the effect wears off or on the days afterwards, depressive moods may occur.", "longtermRisks": "After a consumption experience, the body needs at least 4 weeks to regenerate the serotonin balance. If one does not allow oneself this break in the long term and consumes repeatedly after short breaks, the probability of a permanent restriction of spatial awareness increases. This risk also exists after repeated high doses. Intense and prolonged use of ecstasy can also lead to a change in the serotonin system. A form of dependence with psychological symptoms can develop, especially if ecstasy use is linked to a certain activity, for example if it is always used at parties and partying without ecstasy afterwards is no longer possible. In the case of snorting, the nasal mucous membranes and the nasal wall are damaged. Rectal use can cause irritation in the rectum.", "saferUse": [ "If you want to be sure that your pill really contains MDMA and know the dose, use drug checking. If this is not possible, first consume only one third of the pill.", "Do not add more right away, but wait two hours for the full effect and then decide.", "Avoid mixed use with other substances.", "Avoid alcohol and drink enough non-alcoholic beverages. Approx. 3 dl per hour is enough. Isotonic drinks are best to avoid hyponatremia (\"water intoxication\").", "Take breaks from dancing at parties and get some fresh air.", "Do not wear headgear, except in strong sun (danger of overheating!).", "Do not take ecstasy immediately after a meal, but also not on an empty stomach. It is advisable to have a light, healthy meal a few hours before.", "Accept when the effect runs out. \"Re-spiking\" increases the toxicity (poisonousness) of MDMA.", "Give yourself time to recover and take regular breaks (at least 4-6 weeks) to restore serotonin levels.", "If you use MDMA nasally, follow the safe-sniffing rules. If consuming rectally, use lubricant to minimise the risk of rectal irritation.", "If you are taking medication, ask your doctor about possible interactions. If you are taking psychotropic drugs, the use of MDMA is strongly discouraged (risk of serotonin syndrome)!", "Ecstasy can cause asthma attacks in asthmatics and epileptic seizures in epileptics.", "People with high blood pressure, heart problems, hyperthyroidism, liver and kidney diseases or circulatory problems should refrain from using MDMA.", "There is a small percentage of people, who due to their race and family history, have a lower level of the liver enzyme P450 2D6. This can cause them to be more sensitive to MDMA, requiring lower doses and extra caution should be taken." ], "interactions": { "dangerous": [ "Tramadol", "MAOI", "Dextromethorphan" ], "unsafe": [ "25x-NBOMe", "PCP", "Serotonin releasers", "2C-T-x", "5-Hydroxytryptophan" ], "uncertain": [ "5-MeO-xxT", "Alcohol", "Cocaine", "DOx", "GHB", "GBL", "Methoxetamine", "ΑMT", "Protease Inhibitors", "SSRIs", "SNRIs" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 80, "strongMin": 120, "heavyMin": 150 }, "duration": { "onset": { "min": 30, "max": 45, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 12, "max": 48, "units": "hours" } } } ] }, { "name": "MDPV", "commonNames": [ "MDPV", "Bath Salts", "NRG-1" ], "url": "https://psychonautwiki.org/wiki/MDPV", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "entactogen", "stimulant", "research-chemical", "habit-forming" ], "summary": "MDPV is a potent, and extremely compulsive synthetic euphoric stimulant, which shares some empathogenic effects with MDMA. Has a reputation for causing psychosis. MDPV has been found in products sold as \"bath salts\", \"plant food/fertilizer\", and in some \"ecstasy.\"", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 8, "strongMin": 14, "heavyMin": 25 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 1, "max": 4, "units": "hours" }, "offset": { "min": 0.5, "max": 2, "units": "hours" }, "total": { "min": 2, "max": 7, "units": "hours" }, "afterglow": { "min": 2, "max": 48, "units": "hours" } } } ] }, { "name": "Mebroqualone", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Mebroqualone", "isApproved": false, "tolerance": { "full": "within a couple of days of repeated administration", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "GABA|gabaergic", "depressants" ], "addictionPotential": "extremely addictive", "toxicities": [ "safe at appropriate dosages" ], "categories": [ "depressant", "research-chemical", "habit-forming", "tentative" ], "summary": "A short acting analogue of Methaqualone, that is much more potent.", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 5, "strongMin": 10, "heavyMin": 15 }, "duration": { "total": { "min": 1, "max": 2, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 2, "commonMin": 4, "strongMin": 8, "heavyMin": 12 }, "duration": { "total": { "min": 1, "max": 2, "units": "hours" } } } ] }, { "name": "Melatonin", "commonNames": [ "Melatonin" ], "url": "https://psychonautwiki.org/wiki/Melatonin", "isApproved": true, "tolerance": { "full": "after prolonged and repeated usage", "half": "7 days", "zero": "14 days", "halfToleranceInHours": 168, "zeroToleranceInHours": 336 }, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "extremely low toxicity" ], "categories": [ "oneirogen", "nootropic", "common" ], "summary": "A naturally occurring hormone produced in the body, which promotes sleep at certain times in the day based on the circadian rhythm. It is also commonly available as a drug to treat insomnia and promote a proper sleep cycle. It can be used to promote sleepfulness at the tail-end of drug experiences, though it is not particularly hypnotic.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.25, "commonMin": 1, "strongMin": 3, "heavyMin": 6 }, "duration": { "onset": { "min": 5, "max": 20, "units": "minutes" }, "total": { "min": 6, "max": 10, "units": "hours" } }, "bioavailability": { "min": 15, "max": 15 } } ] }, { "name": "Memantine", "commonNames": [ "Memantine", "Memaxa", "Ebixa", "Namenda", "Namenda XR", "Namzaric (with donepezil", "both extended-release)" ], "url": "https://psychonautwiki.org/wiki/Memantine", "isApproved": true, "crossTolerances": [ "dissociatives" ], "addictionPotential": "unknown", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative", "deliriant", "tentative" ], "summary": "An NMDA-antagonist that if used recreationally can cause to a very prolonged \"hole\" lasting up to 16+ hours.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 70, "strongMin": 110, "heavyMin": 170 }, "duration": { "onset": { "min": 2, "max": 3, "units": "hours" }, "comeup": { "min": 2, "max": 3, "units": "hours" }, "peak": { "min": 3, "max": 12, "units": "hours" }, "offset": { "min": 5, "max": 24, "units": "hours" }, "total": { "min": 18, "max": 36, "units": "hours" }, "afterglow": { "min": 8, "max": 24, "units": "hours" } } } ] }, { "name": "Mephedrone", "commonNames": [ "Mephedrone", "4-MMC", "Drone", "M-CAT", "Meow Meow" ], "url": "https://psychonautwiki.org/wiki/Mephedrone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "research-chemical", "habit-forming" ], "summary": "A shortlived euphoric stimulant, developed as an analogue of MDMA, which was extremely popular in the research chemical scene before being banned. Commonly seen on street markets but rarer online. Very strong urge to redose compulsively.", "effectsSummary": "The effect is similar to that of methcathinone, cocaine and MDMA. Mephedrone causes euphoria and stimulation, increased urge to talk, increased performance and altered sensory perceptions. The need for food and sleep is suppressed.", "generalRisks": "Various adverse effects may occur when consuming mephedrone: Dry mouth, mydriasis (dilated pupils), jaw grinding, increased heartbeat, increase in body temperature, anxiety or paranoia. There is a risk of dehydration due to decreased thirst and lack of fluid intake. High doses of mephedrone lead to psychotic reactions and can increase schizophrenia. There is a risk of dependence with symptoms such as restlessness, tremors, insomnia and hyperactivity.\nMephedrone is a research chemical. To date, nothing is known about the exact mechanisms of action, toxicity and possible long-term effects. The current state of knowledge is based almost exclusively on reports from users. Due to the strong craving (irresistible and uncontrollable desire to consume), especially when consumed nasally/smoked, there is a danger that one will take more too quickly and the side effects will predominate.", "saferUse": [ "There is very little knowledge about legal highs, research chemicals, etc. When you use them, you are exposing yourself to unknown risks. Have the substance analysed in a drug check. If this is not possible and you still want to use the substance, try small amounts to reach the desired dose.", "Do not buy a product with a fancy name without a declaration of the ingredient. Legal does not mean harmless.", "During consumption, inform your friends about what and how much you have consumed.", "Drink enough non-alcoholic beverages and get some fresh air in between.", "Accept it when the effect runs out, don't add to it right away.", "Refrain from mixed consumption, as interactions are dangerous and unexplored.", "Take regular breaks from consumption.", "People with high blood pressure, heart problems, hyperthyroidism, liver and kidney disease or circulatory problems should not take Research Chemicals." ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 45, "strongMin": 80, "heavyMin": 125 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 30, "max": 60, "units": "minutes" }, "offset": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 15, "commonMin": 100, "strongMin": 200, "heavyMin": 300 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "Mescaline", "commonNames": [ "Mescaline", "Peyote", "San Pedro", "Cactus", "Buttons" ], "url": "https://psychonautwiki.org/wiki/Mescaline", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "common" ], "summary": "A psychedelic of the phenethylamine family. Found in psychedelic cacti that have long been used by peoples native to the Southwestern US and Mexico, including Peyote and San Pedro cacti, among others. Can be found as cactus pulp, as an extract from cacti, or as a synthetic substance created in a lab.", "effectsSummary": "Before the effect sets in, nausea and/or vomiting can often occur. Hot and cold flushes as well as sweating and dizziness may also occur. These side effects usually subside after a while. The trip begins with hyperactivity and inner restlessness, followed by altered, sharpened perception and intensified colour vision. In a second phase, a more meditative concentration occurs. Users report visions and a euphoria of religious depth, the feeling of a visionary experience and the change of ego sensation as well as feelings of ego dissolution.", "dosageRemark": "The mescaline content can vary greatly from plant to plant.", "generalRisks": "The pharmacological effect of mescaline and the bitter taste usually lead to nausea and vomiting in the initial phase of the trip. Mescaline is toxic in high doses (from approx. 2 g) and can lead to liver damage and respiratory paralysis. Other side effects may include an increase in pulse and blood pressure, initially dry mouth, then increased salivation, pupil enlargement, increase in body temperature and a reduced feeling of hunger during the period of effect. During vomiting, users may choke on the vomit (danger of choking!).", "longtermRisks": "The use of mescaline can trigger latent (hidden) mental disorders even with single use.", "saferUse": [ "Mescaline is not suitable as a party drug and should only be used by experienced users.", "Use mescaline only if you are well prepared and in an environment where you feel comfortable. Use mescaline only in the presence of friends who are experienced users (good setting) and/or a sober person (tripsitter).", "Only use mescaline when you feel good mentally and physically (good set).", "You should have respect but not fear for the mescaline effect.", "Mescaline should be taken on an empty stomach. Fasting before the trip may help to reduce the likelihood of nausea and vomiting.", "For nausea, it helps if you take mescaline in small doses at a time.", "Don't add to it if it doesn't work right away.", "Let yourself go during the trip, don't try to fight the effects of mescaline. A trip sitter can help you with this.", "Dextrose can help against circulatory problems.", "Avoid roads and other \"dangerous\" places. Your orientation may be disturbed.", "Drink enough water during the trip.", "Mixed use of this potent substance should be avoided at all costs, as the effect can then no longer be assessed.", "Plan enough time for recovery after the trip (at least 1 day)!", "Mescaline trips should remain exceptional experiences and should in no case be experienced more than once a month.", "People with mental problems or illnesses, people taking neuroleptics and people with circulatory and heart problems should refrain from using mescaline." ], "interactions": { "dangerous": [ "ΑMT" ], "unsafe": [ "Tramadol" ], "uncertain": [ "5-MeO-xxT", "Cannabis", "Substituted amphetamines", "Cocaine", "MAOI" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 200, "strongMin": 400, "heavyMin": 800 }, "duration": { "onset": { "min": 45, "max": 90, "units": "minutes" }, "comeup": { "min": 60, "max": 120, "units": "minutes" }, "peak": { "min": 4, "max": 6, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 8, "max": 14, "units": "hours" }, "afterglow": { "min": 6, "max": 36, "units": "hours" } } } ] }, { "name": "MET", "commonNames": [ "MET", "Methylethyltryptamine" ], "url": "https://psychonautwiki.org/wiki/MET", "isApproved": true, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical", "tentative" ], "summary": "A rare psychedelic tryptamine, related to DMT and DET. Little information exists about the effects or pharmacology of this drug.", "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 25, "heavyMin": 35 }, "duration": { "onset": { "min": 2, "max": 5, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1, "max": 1.5, "units": "hours" }, "offset": { "min": 1, "max": 2.5, "units": "hours" }, "total": { "min": 2, "max": 4, "units": "hours" }, "afterglow": { "min": 4, "max": 12, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 40, "commonMin": 120, "strongMin": 150, "heavyMin": 200 }, "duration": { "onset": { "min": 1, "max": 2, "units": "hours" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 10, "commonMin": 40, "strongMin": 60, "heavyMin": 90 }, "duration": { "onset": { "min": 30, "max": 60, "units": "seconds" }, "peak": { "min": 10, "max": 20, "units": "minutes" }, "offset": { "min": 20, "max": 40, "units": "minutes" }, "total": { "min": 30, "max": 75, "units": "minutes" }, "afterglow": { "min": 20, "max": 60, "units": "minutes" } } } ] }, { "name": "Methadone", "commonNames": [ "Methadone", "Dolophine", "Methadose" ], "url": "https://psychonautwiki.org/wiki/Methadone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "extremely addictive with a high potential for abuse", "toxicities": [ "moderate toxicity", "potentially lethal when mixed with depressants like alcohol or benzodiazepines" ], "categories": [ "opioid", "habit-forming", "depressant", "common" ], "summary": "A synthetic opioid drug used as an analgesic and is often used in detoxification off of other opioids. As it has a much longer half-life.", "interactions": { "dangerous": [ "SNRIs", "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 15, "heavyMin": 30 }, "duration": { "onset": { "min": 20, "max": 90, "units": "minutes" }, "peak": { "min": 6, "max": 8, "units": "hours" }, "afterglow": { "min": 1, "max": 24, "units": "hours" } } } ] }, { "name": "Methallylescaline", "commonNames": [ "Methallylescaline", "MAL" ], "url": "https://psychonautwiki.org/wiki/Methallylescaline", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "Mescaline analogue first synthesised by Alexander Shulgin, derived from and less potent than allylescaline. A psychedelic phenethylamine which causes stimulation, euphoria and hallucinatory experiences.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 25, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 6, "max": 12, "units": "hours" }, "afterglow": { "min": 4, "max": 8, "units": "hours" } } } ] }, { "name": "Methamphetamine", "commonNames": [ "Methamphetamine", "Meth", "Speed", "Ice", "Glass", "Shard", "Tina", "Crank", "Desoxyn", "Crystal", "Ma", "T", "Tweak", "Shabu", "Yaba" ], "url": "https://psychonautwiki.org/wiki/Methamphetamine", "isApproved": true, "tolerance": { "full": "rapidly develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulants" ], "addictionPotential": "extremely addictive with a high potential for abuse", "toxicities": [], "categories": [ "stimulant", "habit-forming", "common" ], "summary": "A fairly common and very strong CNS stimulant. It is sometimes prescribed in the form of desoxyn for ADHD and severe obesity. In low doses, methamphetamine can elevate mood, increase alertness, concentration, energy and reduces appetite. At higher doses, it can induce mania, psychosis and muscle degeneration among other issues. Tolerant users may report much higher doses than new users.", "effectsSummary": "The body's own performance drug noradrenaline is released, the simultaneous release of dopamine increases self-esteem. Since methamphetamine reaches the brain more quickly than amphetamine and the stimulating effect is stronger, it causes a stronger high and has a higher addiction potential than amphetamine. The body temperature rises, pulse and breathing are accelerated, blood pressure is increased. Hunger and the need for sleep are suppressed. The willingness to take risks is increased, the sensation of pain is suppressed, and euphoria, extreme nervousness, and an increased urge to talk (\"babble flash\") can occur. Methamphetamine has a pleasure-increasing and disinhibiting effect, which is why it is also used as a sex drug.", "generalRisks": "Methamphetamine can sometimes hardly be distinguished from amphetamine, but has a much stronger effect. Short-term side effects are: tense jaw muscles, dry mouth, temperature increase, great loss of fluid, increased heart rate as well as increased blood pressure and trembling all over the body. Irritability and aggressive behaviour can also occur (especially in combination with alcohol).", "longtermRisks": "Methamphetamine is a highly depleting substance with a very high dependence potential with psychological and physical symptoms. Aggression, depression, mental coldness and the desire for more characterise the period of regular use. Constant restlessness, sleep and circulatory disorders, paranoia and even amphetamine psychosis can occur. Weight loss, skin inflammations (\"speed pimples\"), tooth loss, stomach problems and cramps are also possible. In menstruating persons, the menstrual cycle may be disturbed. Snorting damages the nasal mucous membranes and nasal septum, swallowing damages the stomach mucous membranes. Chronic consumption favours brain haemorrhages and strokes with sudden paralysis. It is suspected that the use of methamphetamine (especially mixed use with MDMA) can lead to irreversible changes or damage in the brain!", "saferUse": [ "Dose low, methamphetamine is a highly potent substance!", "Take vitamin C and D and minerals (iron, calcium and magnesium) with frequent use.", "Eat enough after consumption to prevent weight loss.", "Drink a lot (soft drinks).", "Follow the safer-sniffing and safer-sex rules.", "Refrain from mixed consumption. Make sure to take breaks from consumption.", "Mentally ill persons, persons with high blood pressure, liver and kidney diseases, diabetics and pregnant women should not use methamphetamine.", "It is better not to wear headgear (danger of overheating!).", "Have your substance analysed in a drug check." ], "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 30, "heavyMin": 60 }, "duration": { "onset": { "min": 3, "max": 5, "units": "minutes" }, "comeup": { "min": 3, "max": 5, "units": "minutes" }, "peak": { "min": 1.5, "max": 3, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 4, "max": 7, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } }, { "name": "intravenous", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 30, "heavyMin": 40 }, "duration": { "onset": { "min": 15, "max": 30, "units": "seconds" }, "comeup": { "min": 1, "max": 2, "units": "minutes" }, "peak": { "min": 1, "max": 3, "units": "hours" }, "offset": { "min": 3, "max": 4, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 12, "max": 24, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 25, "heavyMin": 50 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 1, "max": 3, "units": "hours" }, "peak": { "min": 3, "max": 5, "units": "hours" }, "offset": { "min": 3, "max": 4, "units": "hours" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 12, "max": 24, "units": "hours" } } }, { "name": "rectal", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 30, "heavyMin": 40 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "comeup": { "min": 3, "max": 5, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 3, "max": 5, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" }, "afterglow": { "min": 12, "max": 24, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 20, "heavyMin": 60 }, "duration": { "onset": { "min": 7, "max": 10, "units": "seconds" }, "comeup": { "min": 5, "max": 10, "units": "seconds" }, "peak": { "min": 1, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 2, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 24, "units": "hours" } } } ] }, { "name": "Methaqualone", "commonNames": [ "Methaqualone", "Quaaludes", "Ludes", "Mandrax", "Sopor", "Quack", "Vitamin Q", "Soaper" ], "url": "https://psychonautwiki.org/wiki/Methaqualone", "isApproved": true, "tolerance": { "full": "within a couple of days of repeated administration", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "GABA|gabaergic", "depressants" ], "addictionPotential": "extremely addictive", "toxicities": [ "doses of over 300mg can be dangerous for first time users", "safe at appropriate dosages" ], "categories": [ "depressant", "habit-forming" ], "summary": "A pharmaceutical depressant and sedative phased out due to the better safety profile of benzodiazepines, part of the Qualone group of substances. Now very rare, except in South Africa.", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 75, "commonMin": 300, "strongMin": 500, "heavyMin": 600 }, "duration": { "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 6, "max": 8, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 50, "commonMin": 100, "strongMin": 200, "heavyMin": 300 }, "duration": { "total": { "min": 1, "max": 2, "units": "hours" } } } ] }, { "name": "Methiopropamine", "commonNames": [ "MPA" ], "url": "https://psychonautwiki.org/wiki/Methiopropamine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 40, "heavyMin": 60 } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 30, "strongMin": 50, "heavyMin": 60 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 4, "units": "hours" }, "offset": { "min": 2, "max": 3, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" }, "afterglow": { "min": 1, "max": 2, "units": "hours" } } } ] }, { "name": "Methoxetamine", "commonNames": [ "Methoxetamine", "MXE", "Mexxy" ], "url": "https://psychonautwiki.org/wiki/Methoxetamine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative" ], "interactions": { "dangerous": [ "ΑMT", "Alcohol", "GHB", "GBL", "Opioids", "Tramadol" ], "unsafe": [ "MAOI" ], "uncertain": [ "DOx", "25x-NBOMe", "2C-T-x", "PCP", "Substituted amphetamines", "MDMA", "Cocaine", "Benzodiazepines", "SSRIs" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 35, "heavyMin": 60 }, "duration": { "onset": { "min": 5, "max": 20, "units": "minutes" }, "comeup": { "min": 30, "max": 75, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 3, "max": 5, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 25, "strongMin": 45, "heavyMin": 70 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 1.5, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 6, "max": 48, "units": "hours" } } } ] }, { "name": "Methoxphenidine", "commonNames": [ "Methoxphenidine", "Methoxyphenidine", "MXP", "2-MXP" ], "url": "https://psychonautwiki.org/wiki/Methoxphenidine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative", "research-chemical", "tentative", "habit-forming" ], "summary": "A dissociative from the diarylethylamine class, a more potent analogue of diphenidine. Known to be unpredictable, and can cause blackouts.", "interactions": { "dangerous": [ "Depressant", "Stimulants", "Dissociatives" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 30, "commonMin": 75, "strongMin": 120, "heavyMin": 150 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 6, "max": 8, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } } ] }, { "name": "Methylnaphthidate", "commonNames": [ "Methylnaphthidate", "HDMP-28" ], "url": "https://psychonautwiki.org/wiki/Methylnaphthidate", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "MDMA", "Cocaine" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 4, "commonMin": 8, "strongMin": 14, "heavyMin": 28 }, "duration": { "onset": { "min": 3, "max": 6, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 90, "max": 180, "units": "minutes" }, "afterglow": { "min": 1, "max": 2, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 4, "commonMin": 15, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 1, "max": 10, "units": "minutes" }, "peak": { "min": 1.5, "max": 2, "units": "hours" }, "offset": { "min": 1.5, "max": 2, "units": "hours" }, "total": { "min": 2, "max": 5, "units": "hours" }, "afterglow": { "min": 1, "max": 8, "units": "hours" } } } ] }, { "name": "Methylone", "commonNames": [ "Methylone", "bk-MDMA", "M1", "MDMC" ], "url": "https://psychonautwiki.org/wiki/Methylone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "1 - 3 weeks", "zero": "3 - 6 weeks", "halfToleranceInHours": 336, "zeroToleranceInHours": 756 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "entactogen", "stimulant", "psychedelic", "research-chemical", "habit-forming", "common" ], "summary": "βk-MDMA is a cathinone stimulant and empathogen, similar in structure to MDMA, though more stimulating and less empathogenic in comparison. Was very commonly mis-sold as MDMA on the street until it was banned in 2013. The Marquis reagent can differentiate βk-MDMA from MDMA. Less potent than MDMA with a slightly shorter duration.", "effectsSummary": "Compared to MDMA, methylone has a stronger stimulating and less empathogenic effect. The effect is more constant, the \"hangover\" less than with MDMA.", "generalRisks": "Short-term side effects are increased body temperature and heartbeat, dilated pupils and tightening of the jaw. The side effects and the (long-term) risks of methylone have hardly been researched yet.", "saferUse": [ "Refrain from re-throwing: This does not intensify or prolong the flash with methylone.", "Be sure to drink enough water during the effect.", "Do not combine methylone with alcohol and other drugs, especially MAO inhibitors.", "Do not use methylone if you have heart or circulatory problems, high blood pressure, diabetes, asthma, epilepsy or mental health problems." ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 75, "commonMin": 150, "strongMin": 225, "heavyMin": 325 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 15, "max": 45, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 60, "max": 90, "units": "minutes" }, "total": { "min": 2.5, "max": 4, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "Methylphenidate", "commonNames": [ "Methylphenidate", "Concerta", "Methylin", "Ritalin", "Equasym XL" ], "url": "https://psychonautwiki.org/wiki/Methylphenidate", "isApproved": true, "crossTolerances": [], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [], "categories": [ "stimulant", "habit-forming", "common" ], "summary": "A psychostimulant commonly used in the treatment of ADHD, narcolepsy and obesity, particularly in the EU instead of Adderall. Methylphenidate is also a 5HT1A receptor agonist. Sometimes prescribed off-label to help the withdrawals from cocaine and other stimulants.", "effectsSummary": "Taking methylphenidate increases the concentration of the nerve messengers dopamine, noradrenaline and serotonin in the brain. When prescribed for ADHD, the drug is supposed to act as a filter for incoming stimuli and alleviate symptoms such as distractibility, attention deficit disorder, disorganisation and impulsivity.\nHowever, due to its stimulating, energising and drive-enhancing properties, methylphenidate is also used as a party drug or to increase performance. Due to the increased release of dopamine, similar effects occur as with the use of cocaine.", "generalRisks": "If prescribed by a doctor or used as directed, sleep disturbances and irritability can often occur. Eating disorders, stomach complaints, nausea and vomiting are also known side effects.\nAbusive use and higher doses can lead to seizures, cardiac arrhythmias as well as headaches and confusion.\nTolerance develops relatively quickly, which is why higher and higher doses have to be consumed. In overdose, Ritalin can trigger hallucinations.", "longtermRisks": "It is assumed that no dependence develops with therapeutic use of Ritalin. When abusing higher doses over a longer period of time, psychological dependence may develop. With abrupt discontinuation, withdrawal symptoms such as lethargy, apathy, depression and paranoia may occur.", "saferUse": [ "If possible, do not consume methylphenidate intravenously. Due to the substances contained in the tablets, embolism (blockage of lung or brain vessels) can occur." ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 30, "heavyMin": 60 }, "duration": { "onset": { "min": 5, "max": 20, "units": "minutes" }, "comeup": { "min": 15, "max": 40, "units": "minutes" }, "peak": { "min": 30, "max": 45, "units": "minutes" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 2, "max": 4, "units": "hours" }, "afterglow": { "min": 1, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 1.5, "max": 2.5, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "Metizolam", "commonNames": [ "Metizolam", "Desmethyletizolam" ], "url": "https://psychonautwiki.org/wiki/Metizolam", "isApproved": true, "tolerance": { "full": "within a couple of days of repeated administration", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "thienzodiazepines", "benzodiazepines" ], "addictionPotential": "extremely addictive", "toxicities": [ "large therapeutic index and margin of safety" ], "categories": [ "depressant", "benzodiazepine", "research-chemical", "habit-forming", "tentative" ], "summary": "Also known as desmethyletizolam, a thienodiazepine similar in effects and structure to etizolam, but around half as potent and with around a 60% longer half-life. A sedative, and hypnotic, it may cause amnesia and lowered inhibitions in excess.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 2, "strongMin": 4, "heavyMin": 6 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 10, "max": 30, "units": "hours" } } } ] }, { "name": "Mexedrone", "commonNames": [ "Mexedrone", "4-MMC-MeO" ], "url": "https://psychonautwiki.org/wiki/Mexedrone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "entactogen", "research-chemical", "habit-forming", "tentative" ], "summary": "Mexedrone is a stimulant drug of the cathinone class. It alters the reuptake of serotonin, dopamine, and norepinephrine to cause euphoria, and is similar in effects to mephedrone. It is considered a designer drug and is in a legally grey area globally.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 150, "strongMin": 250, "heavyMin": 350 }, "duration": { "total": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "Midazolam", "commonNames": [ "Midazolam", "Versed" ], "url": "https://psychonautwiki.org/wiki/Midazolam", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "depressant", "benzodiazepine", "habit-forming" ], "summary": "A common hypnotic, sedative and anxiolytic benzodiazepine. High doses may cause amnesia and loss of inhibitions. Unusually, it is water soluble, and commonly used as a premedication for sedation as the solubility makes it better for IV use than other benzodiazepines.", "effectsSummary": "Midazolam has a calming, relaxing, antispasmodic, anti-anxiety and sleep-inducing effect.\nTaking benzodiazepines increases the effectiveness of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This triggers sedative (calming), hypnotic, anxiolytic (anxiety-relieving), anticonvulsant (anticonvulsant) and muscle-relaxing effects in the body. Benzodiazepines have a depressant effect on the central nervous system. The flow of information in the brain between the brain cells (neurons) is thereby reduced / disturbed and feelings and perceptions are dampened.\nThe breakdown of the individual active ingredients of benzodiazepines in the body is age-dependent and therefore varies from person to person.", "generalRisks": "There is little information available on risks, toxicity, side effects and long-term consequences. Therefore, the general information on benzodiazepines applies:\nWhen mixing with other downers (alcohol, GHB/GBL, heroin) there is a risk of respiratory paralysis!\nTaking benzodiazepines can cause numerous undesirable side effects. In addition, regular and long-term use carries a very high risk of physical and psychological dependence. Benzodiazepines should only be taken as prescribed by a doctor and only for a short period of time (max. 4-6 weeks). Longer-term use should be discussed with the treating specialist. The dosages and duration of action of the individual benzodiazepines differ considerably.\nSide effects of benzodiazepines may be as follows: Prolonged fatigue, gastrointestinal problems, impaired reactions, hypersensitivity reactions, headaches, dizziness, motor difficulties, visual disturbances, slowed breathing, muscle weakness, confusion, sexual dysfunction, aggression, outbursts of anger, restlessness, random movements, allergies, skin problems/rashes and speech and movement disorders. Some benzodiazepines can cause seizures in epileptics.", "longtermRisks": "Regular and long-term use can lead to psychological and physical dependence (very high dependence potential). Immediate discontinuation of the drug after prolonged use can lead to negative withdrawal symptoms (including dizziness, physical weakness, inner restlessness, tremors, sleep disturbances, headaches, sweating, nausea, hallucinations and depression).\nIn addition, seizures and memory disorders/loss and listlessness (hangover effects) can occur. In case of possible dependence, withdrawal should be discussed with a doctor beforehand and the withdrawal should be medically accompanied. It is extremely important that the dose is reduced gradually.", "saferUse": [ "If medicines are obtained on the black market or on the internet and not from a pharmacy/medical facility, the contents are unclear. Have the medicine tested for the exact ingredients in a drug check!", "Do not rely on dosage information from colleagues who regularly use benzodiazepines. Due to habituation or dependence, their doses can be much higher and fatal for new users.", "Blisters of counterfeits may look identical to the original packaging.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, opioids and/or other benzodiazepines is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!" ], "roas": [] }, { "name": "MiPLA", "commonNames": [ "MiPLA", "Lamide" ], "url": "https://psychonautwiki.org/wiki/MiPLA", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "low potential for abuse and dependence", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic" ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 50, "commonMin": 150, "strongMin": 200, "heavyMin": 300 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "comeup": { "min": 45, "max": 90, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "MiPT", "commonNames": [ "MiPT" ], "url": "https://psychonautwiki.org/wiki/MiPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "research-chemical", "tentative" ], "summary": "N-Methyl-N-isopropyltryptamine, a tryptamine analogue of DMT, a very uncommon drug with very few reports of human use. Described as 'more psychedelic than hallucinogenic' users report only mild visuals with some stimulation and cognitive effects. One of the more stable tryptamines.", "roas": [ { "name": "oral", "dose": { "units": "mg", "commonMin": 10, "strongMin": 25, "heavyMin": 75 }, "duration": { "total": { "min": 3, "max": 8, "units": "hours" } } } ] }, { "name": "Mirtazapine", "commonNames": [ "Avanza", "Axit", "Mirtaz", "Mirtazon", "Remeron", "Zispin" ], "url": "https://psychonautwiki.org/wiki/Mirtazapine", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [], "categories": [ "deliriant", "depressant", "antidepressant" ], "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "Antidepressants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3.5, "commonMin": 130, "strongMin": 190, "heavyMin": 250 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 90, "max": 180, "units": "minutes" }, "offset": { "min": 2, "max": 6, "units": "hours" }, "total": { "min": 14, "max": 24, "units": "hours" } } } ] }, { "name": "Modafinil", "commonNames": [ "Modafinil", "Alertec", "Modavigil", "Modiodal", "Provigil", "Modalert" ], "url": "https://psychonautwiki.org/wiki/Modafinil", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzhydryl", "nootropic|nootropics" ], "addictionPotential": "not addictive with a low potential for abuse", "toxicities": [ "The median lethal dose at which 50% of participants die (LD50) from modafinil for human beings has never been reached" ], "categories": [ "eugeroic", "stimulant", "habit-forming", "nootropic", "common" ], "summary": "A wakefulness promoting, long acting stimulant which is typically only used functionally, because there is no real euphoric component to its effects. Also prescribed for daytime sleeping disorders.", "effectsSummary": "The mechanism of action of modafinil is not yet fully understood. It is assumed that modafinil binds to the dopamine transporter and inhibits dopamine reuptake. Unlike other stimulants such as amphetamine or methylphenidate (Ritalin®, Concerta®), which in equivalent wakefulness-promoting doses increase neuronal activity throughout the brain, modafinil acts primarily on the brain regions responsible for controlling waking, sleep, wakefulness and vigilance (sustained attention).\nModafinil thus promotes alertness (physical and mental), increases attention and motor activity. Due to its stimulating, wakefulness-promoting properties, modafinil is consumed by healthy people as a so-called \"smart drug\" or \"cognitive enhancer\".According to user reports, modafinil has a much more subtle effect than other stimulants and does not trigger comparable states of intoxication. Modafinil causes less physical restlessness and the sleep-wake rhythm is less disturbed.\nA mood-lifting and euphoric effect is controversial. According to a publication of the American Food and Drug Administration (FDA), modafinil causes psychoactive and euphoric effects, whereas various studies point to the lack of a euphoric effect.", "dosageRemark": "The recommended daily dose when prescribed by a doctor is 200 mg at the beginning. If there is an insufficient response to this dose, a maximum daily dose of 400 mg may be administered/taken.\nThe long-term effect of modafinil when taken regularly and over a longer period of time has not yet been studied. If taken over a longer period of time, regular monitoring by a medical specialist is therefore recommended.", "generalRisks": "In 2011, the European Medicines Agency (EMA) recommended limiting the marketing authorisation for modafinil to the treatment of adults with excessive sleepiness associated with narcolepsy. Due to the possible risks and side effects, modafinil has since not been approved for other indications, for the treatment of children and adolescents, and during pregnancy and breastfeeding.\nThe following side effects may occur: Headache, nervousness, palpitations, abdominal pain and/or dry mouth. In addition, modafinil can impair the effectiveness of oral contraceptives! Therefore, the use of additional contraceptive methods is recommended during intake. Further risks are cardiovascular diseases such as cardiac arrhythmias, diseases of the heart muscles, cardiac insufficiency and/or high blood pressure. Furthermore, the consumption of modafinil can have an effect on the psyche and trigger hostility, aggression ,psychoses/psychotic disorders, depression, insomnia, up to delusions and/or anxiety.\nSymptoms of overdose with modafinil alone or in combination with other medicines: Insomnia; central nervous symptoms (restlessness, disorientation, confusion, agitation, hallucinations); nausea, diarrhoea; palpitations, high blood pressure, chest pain, slow heartbeat.", "longtermRisks": "Since modafinil affects the dopamine balance in the brain, among other things, there is an increased potential for physical dependence. If modafinil is consumed for the purpose of performance enhancement and promotion of alertness with the intention of being able to achieve high performance with little sleep, there is also a risk of psychological dependence.\nThe long-term effect of modafinil when taken regularly and over a longer period of time has been little studied so far. If taken over a longer period of time, regular monitoring by a medical specialist is therefore recommended.", "saferUse": [ "Caution: The effectiveness of hormonal contraceptives may be impaired by the simultaneous intake of modafinil.", "Side effects such as blurred vision and dizziness may impair the ability to drive or operate machinery.", "Taking modafinil is not a substitute for sleep! Be sure to maintain good sleep hygiene.", "If you are using modafinil for cognitive enhancement, try to think of alternative strategies to improve your memory and recall. Sleep deprivation after taking modafinil in particular can impair cognitive performance.", "Take longer breaks (at least several days) between consumption.", "The effect of modafinil can last up to 10 hours. Therefore, pay attention to the time of intake.", "Remember to drink enough water. This can be forgotten during the effect of modafinil." ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "Hormonal Birth Control", "CYP2C19-substrates" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 100, "strongMin": 200, "heavyMin": 300 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 3.5, "max": 5, "units": "hours" }, "offset": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 5, "max": 10, "units": "hours" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "Morning glory", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Morning_glory", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [], "roas": [] }, { "name": "Morphine", "commonNames": [ "Morphine", "MS-Contin", "Oramorph", "Zomorph", "Sevredol", "Duramorph" ], "url": "https://psychonautwiki.org/wiki/Morphine", "isApproved": true, "crossTolerances": [ "opioids" ], "toxicities": [], "categories": [ "opioid", "habit-forming", "common", "depressant" ], "summary": "The prototypical opioid drug, a powerful analgesic with euphoric qualities, found in the seeds and wax of the plant papaver somniferum (opium poppy). First isolated by Friedrich Sertürner in 1805, named for its sleep-inducing qualities. Do not combine with other depressants, may cause dangerous respiratory depression in overdose.", "effectsSummary": "Due to its strong analgesic, antitussive and psychotropic properties, morphine is used to treat severe pain in emergency and palliative care.\nDue to its depressant and sedative effect, the active substance is also misused as a euphoric intoxicant. In the context of opioid agonist therapy, morphine is used as a substitute for opiate/heroin addiction.", "dosageRemark": "When consuming for the first time, low doses should be used, as the risk of respiratory arrest is increased.", "generalRisks": "Gastrointestinal complaints such as constipation are common side effects after taking opiates. Nausea, vomiting, dry mouth, lack of appetite, abdominal pain, sweating, skin rashes, itching, dizziness, headaches and fatigue are other common complaints. On the psychological level, confusion, nightmares and hallucinations may occur. Rather rarely, there is a drop in blood pressure, breathing difficulties and allergic reactions.\nOverdoses with morphine are life-threatening, as the substance has a strong respiratory depressant effect (worsening breathing) even in low doses, which can lead to respiratory arrest and coma. Oral consumption of 0.3 - 1.5 g and intravenous consumption of 100 mg can lead to a fatal overdose. In opioid addicts, the lethal dose can be significantly higher. An overdose is treated by taking naloxone, an opioid antagonist.", "longtermRisks": "The consumption of morphine can lead to physical and psychological dependence after only a short time. Tolerance builds up quickly, which is why higher and higher doses have to be consumed. Strong withdrawal symptoms such as restlessness, irritability, depression, insomnia, sweating, cold shivers, vomiting, diarrhoea and painful cramps may occur. Like all opiates, morphine can lead to chronic constipation.", "saferUse": [ "Opioids are highly effective drugs that should only be used for a limited time and at best under medical supervision.", "Start with a low dose and wait for the effect and tolerance before adding more. Do not exceed the maximum daily dose.", "If you inject opioids, dose even more carefully, as the range between desired effect (rush) and dangerous overdose is even more difficult to assess. Avoid injecting fentanyl; the risk of overdose is particularly high. Always use new (clean and sterile) injection material! Never exchange syringes, filters, water, disinfection swabs to avoid transmission of hepatitis and HIV.", "Do not rely on dosage information from colleagues who regularly use opioids. Due to habituation or dependence, their doses are much higher and can be fatal for new users.", "Take longer breaks (at least several days) between consumption.", "After a period of abstinence, take a much lower dose! The usual dose before the abstinence phase can otherwise quickly have life-threatening consequences.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, benzodiazepines and/or other opioids is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!", "Refrain from citrus fruits (especially grapefruit) before or during consumption. The combination can lead to an increase in the effect of the opiate and/or to respiratory depression." ], "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 15, "strongMin": 20, "heavyMin": 30 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "MPT", "commonNames": [ "MPT", "Methylpropyltryptamine" ], "url": "https://psychonautwiki.org/wiki/MPT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic" ], "roas": [ { "name": "oral", "dose": { "units": "mg" } } ] }, { "name": "MXiPr", "commonNames": [ "MXiPR", "MXiP" ], "url": "https://psychonautwiki.org/wiki/MXiPr", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "toxic dosage is unknown" ], "categories": [ "dissociative" ], "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 2, "max": 5, "units": "minutes" }, "total": { "min": 1.5, "max": 4, "units": "hours" }, "afterglow": { "min": 2, "max": 12, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "total": { "min": 2, "max": 5, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } } ] }, { "name": "Myristicin", "commonNames": [ "Nutmeg" ], "url": "https://psychonautwiki.org/wiki/Myristicin", "isApproved": true, "crossTolerances": [], "addictionPotential": "is not known to be addictive", "toxicities": [ "is neurotoxic", "can be fatal in extremely high doses" ], "categories": [ "deliriant" ], "interactions": { "dangerous": [ "Opioids", "Dextromethorphan", "Diphenhydramine" ], "unsafe": [ "Stimulants", "Alcohol", "Serotonin releasers" ], "uncertain": [ "Benzodiazepines", "Depressant" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 200, "strongMin": 500, "heavyMin": 800 }, "duration": { "onset": { "min": 3, "max": 8, "units": "hours" }, "comeup": { "min": 1, "max": 4, "units": "hours" }, "peak": { "min": 9, "max": 12, "units": "hours" }, "offset": { "min": 12, "max": 48, "units": "hours" }, "total": { "min": 12, "max": 72, "units": "hours" }, "afterglow": { "min": 24, "max": 72, "units": "hours" } } } ] }, { "name": "N-Acetylcysteine", "commonNames": [ "N-Acetylcysteine" ], "url": "https://psychonautwiki.org/wiki/N-Acetylcysteine", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "nootropic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 100, "commonMin": 600, "strongMin": 1000, "heavyMin": 1500 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "total": { "min": 3, "max": 6, "units": "hours" } } } ] }, { "name": "N-Ethylhexedrone", "commonNames": [ "Hexen", "Hex-en", "NEH", "Ethyl-Hexedrone" ], "url": "https://psychonautwiki.org/wiki/N-Ethylhexedrone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "norepinephrine|noradrenergic", "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 5, "commonMin": 30, "strongMin": 40, "heavyMin": 50 }, "duration": { "onset": { "min": 2, "max": 8, "units": "minutes" }, "peak": { "min": 30, "max": 90, "units": "minutes" }, "offset": { "min": 1, "max": 4, "units": "hours" }, "total": { "min": 2, "max": 5, "units": "hours" }, "afterglow": { "min": 1, "max": 8, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 20 }, "duration": { "onset": { "min": 2, "max": 10, "units": "minutes" }, "peak": { "min": 10, "max": 30, "units": "minutes" }, "offset": { "min": 15, "max": 30, "units": "minutes" }, "total": { "min": 1, "max": 4, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "N-Methylbisfluoromodafinil", "commonNames": [ "N-Methylbisfluoromodafinil", "Dehydroxyfluorafinil", "Modafiendz" ], "url": "https://psychonautwiki.org/wiki/N-Methylbisfluoromodafinil", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "modafanil", "analog" ], "addictionPotential": "mildly addictive with a low potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "nootropic" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 100, "strongMin": 150, "heavyMin": 200 }, "duration": { "total": { "min": 5, "max": 8, "units": "hours" } } } ] }, { "name": "Naloxone", "commonNames": [ "Naloxone", "Narcan", "Evzio" ], "url": "https://psychonautwiki.org/wiki/Naloxone", "isApproved": true, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [], "categories": [ "opioid" ], "roas": [ { "name": "insufflated", "dose": { "units": "mg", "commonMin": 1, "strongMin": 4 }, "duration": { "onset": { "min": 0, "max": 10, "units": "minutes" }, "total": { "min": 30, "max": 60, "units": "minutes" } } }, { "name": "intramuscular", "dose": { "units": "mg", "commonMin": 0.4, "strongMin": 2 }, "duration": { "onset": { "min": 0.25, "max": 2, "units": "minutes" }, "total": { "min": 30, "max": 60, "units": "minutes" } } }, { "name": "intravenous", "dose": { "units": "mg", "commonMin": 0.4, "strongMin": 2 }, "duration": { "onset": { "min": 0.25, "max": 2, "units": "minutes" }, "total": { "min": 30, "max": 60, "units": "minutes" } } } ] }, { "name": "NEP", "commonNames": [ "N-Ethylpentedrone", "NEP", "Ethyl-Pentedrone" ], "url": "https://psychonautwiki.org/wiki/NEP", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI", "SNRIs", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 10, "commonMin": 20, "strongMin": 40, "heavyMin": 60 }, "duration": { "total": { "min": 2, "max": 4, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 25, "strongMin": 40, "heavyMin": 60 }, "duration": { "total": { "min": 4, "max": 6, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 30, "heavyMin": 50 }, "duration": { "total": { "min": 1.5, "max": 3, "units": "hours" } } } ] }, { "name": "Nicotine", "commonNames": [ "Nicotine" ], "url": "https://psychonautwiki.org/wiki/Nicotine", "isApproved": true, "tolerance": { "full": "rapidly develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [], "addictionPotential": "extremely addictive with a high potential for abuse", "toxicities": [ "estimated oral LD50 of 6.5 - 13 mg/kg in humans" ], "categories": [ "stimulant", "habit-forming", "nootropic", "common" ], "summary": "A chemical found in tobacco, aubergines and tomatoes which is considered one of the most addictive drugs in existence. It is a mild stimulant, with stress relieving effects. It is widely used in the form of cigarettes, the use of which carries a high risk of causing cancer or heart issues over time. Increasingly, it is 'vaped' as a purportedly safer alternative to smoking.", "effectsSummary": "Nicotine promotes the release of the hormone adrenaline as well as the neurotransmitters dopamine and serotonin. In low quantities, nicotine thus has a stimulating effect. Nicotine briefly and reversibly accelerates the heartbeat and causes constriction of the blood vessels. The central short-term effects include above all an increase in psychomotor performance as well as attention and memory. In higher doses, nicotine has a calming and muscle-relaxing effect; it reduces feelings of hunger, anxiety and aggression. Nicotine is responsible for addiction to tobacco products.", "dosageRemark": "Individual and dependent on the form of consumption. The lethal dose of nicotine for adults is about 60 mg; for children and adolescents it is significantly lower.", "generalRisks": "Reduction of the amount of oxygen in the blood and impairment of the sense of smell and taste. With regular consumption: increase in blood pressure and heart rate, increased release of adrenaline and increased activity of the gastrointestinal tract. Mostly with first or repeated consumption: drop in blood pressure, lowered body temperature, nausea and/or nausea, headache and dizziness.", "longtermRisks": "The accompanying substances of tobacco smoke (not nicotine) are responsible for the known health consequences of smoking such as increased risk of heart and lung diseases (asthma, chronic bronchitis, heart attack, stroke, thrombosis, lung cancer) and damage to the stomach lining (risk of stomach ulcers). Nicotine is suspected of having a cancer-promoting effect. Nicotine is one of the drugs with the highest dependence potential with psychological and physical symptoms. Withdrawal symptoms can include depression, anxiety, restlessness, insomnia and (in the long term with abstinence) weight gain. Taking medication (e.g. birth control pills) in combination with high tobacco consumption impairs blood circulation (risk of thrombosis!). People with cardiovascular problems, lung and respiratory problems (asthma, chronic bronchitis) should not use tobacco.\nThe accompanying substances of tobacco smoke (not nicotine) are responsible for the known health consequences of smoking such as increased risk of heart and lung diseases (asthma, chronic bronchitis, heart attack, stroke, thrombosis, lung cancer) and damage to the stomach lining (risk of stomach ulcers). Nicotine is suspected of having a cancer-promoting effect. Nicotine is one of the drugs with the highest dependence potential with psychological and physical symptoms. Withdrawal symptoms can include depression, anxiety, restlessness, insomnia and (in the long term with abstinence) weight gain. Taking medication (e.g. birth control pills) in combination with high tobacco consumption impairs blood circulation (risk of thrombosis!). People with cardiovascular problems, lung and respiratory problems (asthma, chronic bronchitis) should not use tobacco.", "saferUse": [ "Tobacco is a legal, freely available and socially accepted drug. However, this does not mean that this psychoactive substance is low-risk and harmless to health!", "With e-cigarettes or vaporizers (vaporisers), there are ways to consume tobacco with less risk.", "Nicotine is easily absorbed through all mucous membranes of the body. There are therefore lower-risk products such as snuff, chewing tobacco or nicotine gum.", "If you shoot yourself, make sure you use good filtering methods.", "For people with cardiovascular problems, risk of heart attack, lung and respiratory problems (asthma, bronchitis), it is recommended not to consume tobacco or to consume only small amounts.", "Women who use hormonal contraception run an increased risk of circulatory disorders, thromboses, varicose veins and thus heart attacks, strokes or pulmonary embolisms (blockage of blood vessels in the lungs) when they use tobacco. Women over 30 are particularly at risk.", "Smoking during pregnancy is generally not advisable, as the toxins in tobacco smoke enter the bloodstream of the foetus via the placenta.", "Always press out your cigarettes well. There is a risk of fire!", "Do not eat tobacco. If tobacco or tobacco dissolved in water is accidentally swallowed (especially by children), an emergency call should be made immediately. There is a danger to life!" ], "roas": [ { "name": "buccal", "dose": { "units": "mg", "lightMin": 0.2, "commonMin": 2, "strongMin": 4, "heavyMin": 6 }, "duration": { "onset": { "min": 3, "max": 15, "units": "minutes" }, "comeup": { "min": 3, "max": 15, "units": "minutes" }, "peak": { "min": 5, "max": 20, "units": "minutes" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 45, "max": 90, "units": "minutes" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 0.2, "commonMin": 0.8, "strongMin": 1.5, "heavyMin": 3.5 }, "duration": { "onset": { "min": 5, "max": 20, "units": "seconds" }, "comeup": { "min": 5, "max": 10, "units": "seconds" }, "peak": { "min": 2, "max": 5, "units": "minutes" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 1, "max": 3, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } } ] }, { "name": "Nifoxipam", "commonNames": [ "Nifoxipam" ], "url": "https://psychonautwiki.org/wiki/Nifoxipam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "research-chemical", "habit-forming", "tentative" ], "summary": "An uncommon and relatively new RC benzodiazepine, and metabolite of the hypnotic benzodiazepine flunitrazepam. Little information about the pharmacological properties of this drug exists. Likely to be a strong sedative and hypnotic.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.1, "commonMin": 0.5, "strongMin": 1, "heavyMin": 2 }, "duration": { "onset": { "min": 45, "max": 120, "units": "minutes" }, "total": { "min": 10, "max": 75, "units": "hours" } } } ] }, { "name": "Nitromethaqualone", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Nitromethaqualone", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [ "psychedelic" ], "roas": [ { "name": "oral", "dose": { "units": "mg" } }, { "name": "sublingual", "dose": { "units": "mg" } } ] }, { "name": "Nitrous", "commonNames": [ "Nitrous Oxide", "Laughing Gas", "Nitrous", "Hippy Crack", "NOS", "Nitro", "N2O", "Nangs" ], "url": "https://psychonautwiki.org/wiki/Nitrous", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [], "addictionPotential": "mildly addictive with a moderate potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative" ], "effectsSummary": "Relaxation, euphoria, optical and acoustic changes in perception, loss of the sense of time.", "dosageRemark": "Mild nausea, headache; in case of excessive and improper consumption, unconsciousness, drop in blood pressure, cardiac arrhythmia, in the worst case death by respiratory paralysis. Danger of suffocation if oxygen supply is insufficient, increased risk of injury from falling when \"stepping away\".", "longtermRisks": "Continuous use of nitrous oxide stresses the nervous system and leads to vitamin B12 deficiency (risk of disturbed cell function and temporary infertility). Dependence with psychological symptoms is possible.", "saferUse": [ "Never inhale nitrous oxide directly from the capsule or gas cylinder (risk of frostbite in the larynx and bronchi!).", "Consume nitrous oxide while sitting or lying down (less risk of injury).", "Take breaks to avoid too high a concentration of nitrous oxide.", "Refrain from mixed consumption, especially with alcohol.", "Persons with cardiovascular or respiratory diseases should not consume nitrous oxide, nor should persons suffering from epilepsy or otitis media. People with broken ribs or who have suffered a diving accident should also refrain from using nitrous oxide.", "Nitrous oxide causes an acute increase in plasma homocysteine that is more pronounced in patients with the methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C gene variant." ], "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Tramadol" ] }, "roas": [ { "name": "inhaled", "dose": { "units": "g", "lightMin": 4, "commonMin": 8, "strongMin": 16, "heavyMin": 40 }, "duration": { "onset": { "min": 5, "max": 10, "units": "seconds" }, "comeup": { "min": 5, "max": 10, "units": "seconds" }, "peak": { "min": 15, "max": 30, "units": "seconds" }, "offset": { "min": 1, "max": 5, "units": "minutes" }, "total": { "min": 1, "max": 5, "units": "minutes" }, "afterglow": { "min": 15, "max": 30, "units": "minutes" } } } ] }, { "name": "NM-2-AI", "commonNames": [], "url": "https://psychonautwiki.org/wiki/NM-2-AI", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "entactogen" ], "summary": "Stimulant that is in the aminoindane class. Is it quite close to it's bigger brother 2-AI. Yet this has a lower potency, has a longer duration though.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 100, "strongMin": 150, "heavyMin": 200 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "O-Desmethyltramadol", "commonNames": [ "O-Desmethyltramadol" ], "url": "https://psychonautwiki.org/wiki/O-Desmethyltramadol", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "moderate potential toxicity relative to its dose due to its potency", "potentially lethal when mixed with depressants like alcohol or benzodiazepines" ], "categories": [ "opioid", "research-chemical", "habit-forming", "tentative", "depressant" ], "summary": "A opioid analgesic which is the main active metabolite of Tramadol. Alone, it is a few times more potent than Tramadol and has additional affinity for δ and κ-opioid receptors. Has proven popular when sold, but these occasions have been rare due to patent rights.", "interactions": { "dangerous": [ "SNRIs", "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 25, "strongMin": 50, "heavyMin": 100 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } }, { "name": "sublingual", "dose": { "units": "mg", "lightMin": 5, "commonMin": 25, "strongMin": 50, "heavyMin": 80 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 2, "max": 5, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 5, "max": 10, "units": "hours" }, "afterglow": { "min": 1, "max": 3, "units": "hours" } } } ] }, { "name": "O-PCE", "commonNames": [ "O-PCE", "Eticyclidone" ], "url": "https://psychonautwiki.org/wiki/O-PCE", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "dissociative", "research-chemical", "habit-forming", "tentative" ], "summary": "Dissociative of the Arylcyclohexylamine class. Structurally related to Deschloroketamine.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 2, "commonMin": 6, "strongMin": 12, "heavyMin": 20 }, "duration": { "onset": { "min": 2, "max": 5, "units": "minutes" }, "total": { "min": 3, "max": 5, "units": "hours" }, "afterglow": { "min": 2, "max": 12, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 15, "heavyMin": 25 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } } ] }, { "name": "Omberacetam", "commonNames": [ "Noopept", "Ноопепт", "GVS-111", "Omberacetam" ], "url": "https://psychonautwiki.org/wiki/Omberacetam", "isApproved": true, "tolerance": { "full": "develops over several weeks of prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "racetam", "nootropic" ], "addictionPotential": "non-addictive with a low potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "nootropic" ], "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 20 }, "duration": { "onset": { "min": 0, "max": 5, "units": "minutes" }, "peak": { "max": 2, "units": "hours" }, "offset": { "max": 3, "units": "hours" }, "total": { "min": 2, "max": 5, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 10, "strongMin": 20, "heavyMin": 40 }, "duration": { "total": { "min": 3, "max": 5, "units": "hours" } } } ] }, { "name": "Oroxylin A", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Oroxylin_A", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [], "roas": [] }, { "name": "Orphenadrine", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Orphenadrine", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [], "roas": [] }, { "name": "Oxazepam", "commonNames": [ "Oxazepam", "Serax", "Ceresta" ], "url": "https://psychonautwiki.org/wiki/Oxazepam", "isApproved": false, "crossTolerances": [], "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "benzodiazepine", "depressant", "habit-forming" ], "summary": "A prescription benzodiazepine with intermediate duration and half life. A sedative and hypnotic which may cause lowered inhibitions and amnesia in higher doses.", "effectsSummary": "Oxazepam has a calming, relaxing, antispasmodic, anti-anxiety and sleep-inducing effect.\nTaking benzodiazepines increases the effectiveness of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor. This triggers sedative (calming), hypnotic, anxiolytic (anxiety-relieving), anticonvulsant (anticonvulsant) and muscle-relaxing effects in the body. Benzodiazepines have a depressant effect on the central nervous system. The flow of information in the brain between the brain cells (neurons) is thereby reduced / disturbed and feelings and perceptions are dampened.\nThe breakdown of the individual active ingredients of benzodiazepines in the body is age-dependent and therefore varies from person to person.", "generalRisks": "There is little information available on risks, toxicity, side effects and long-term consequences. Therefore, the general information on benzodiazepines applies:\nWhen mixing with other downers (alcohol, GHB/GBL, heroin) there is a risk of respiratory paralysis!\nTaking benzodiazepines can cause numerous undesirable side effects. In addition, regular and long-term use carries a very high risk of physical and psychological dependence. Benzodiazepines should only be taken as prescribed by a doctor and only for a short period of time (max. 4-6 weeks). Longer-term use should be discussed with the treating specialist. The dosages and duration of action of the individual benzodiazepines differ considerably.\nSide effects of benzodiazepines may be as follows: Prolonged fatigue, gastrointestinal problems, impaired reactions, hypersensitivity reactions, headaches, dizziness, motor difficulties, visual disturbances, slowed breathing, muscle weakness, confusion, sexual dysfunction, aggression, outbursts of anger, restlessness, random movements, allergies, skin problems/rashes and speech and movement disorders. Some benzodiazepines can cause seizures in epileptics.", "longtermRisks": "Regular and long-term use can lead to psychological and physical dependence (very high dependence potential). Immediate discontinuation of the drug after prolonged use can lead to negative withdrawal symptoms (including dizziness, physical weakness, inner restlessness, tremors, sleep disturbances, headaches, sweating, nausea, hallucinations and depression).\nIn addition, seizures and memory disorders/loss and listlessness (hangover effects) can occur. In case of possible dependence, withdrawal should be discussed with a doctor beforehand and the withdrawal should be medically accompanied. It is extremely important that the dose is reduced gradually.", "saferUse": [ "If medicines are obtained on the black market or on the internet and not from a pharmacy/medical facility, the contents are unclear. Have the medicine tested for the exact ingredients in a drug check!", "Do not rely on dosage information from colleagues who regularly use benzodiazepines. Due to habituation or dependence, their doses can be much higher and fatal for new users.", "Blisters of counterfeits may look identical to the original packaging.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, opioids and/or other benzodiazepines is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!" ], "interactions": { "dangerous": [ "Depressant", "Dissociatives", "Stimulants" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 15, "strongMin": 30, "heavyMin": 45 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "comeup": { "min": 2, "max": 3, "units": "hours" }, "peak": { "min": 6, "max": 8, "units": "hours" }, "total": { "min": 8, "max": 12, "units": "hours" } } } ] }, { "name": "Oxiracetam", "commonNames": [ "Oxiracetam" ], "url": "https://psychonautwiki.org/wiki/Oxiracetam", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "racetam", "nootropic" ], "addictionPotential": "non-addictive with a low potential for abuse", "toxicities": [ "safe even when high doses are consumed for a long period of time", "exact toxic dosage is unknown" ], "categories": [ "stimulant", "nootropic" ], "summary": "Oxiracetam is a racetam nootropic, having a hydroxyl group being the only difference between this and Piracetam. It used as a nootropic, namely for increased cognitive function. It is usually used two to three times a day. This substance is normally taken with Choline, can cause headaches without the addition of Choline.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 250, "commonMin": 1200, "strongMin": 1800, "heavyMin": 2400 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 8, "max": 10, "units": "hours" } } } ] }, { "name": "Oxycodone", "commonNames": [ "OxyContin", "Oxy", "Roxicodone", "Oxecta", "OxyIR", "Endone", "Oxynor", "Codilek", "Oxydor", "Redocam", "Oxygesic" ], "url": "https://psychonautwiki.org/wiki/Oxycodone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or benzodiazepines" ], "categories": [ "opioid", "habit-forming", "depressant", "common" ], "summary": "A semisynthetic opioid analgesic developed in 1917, prescribed primarily for pain management. It has become extremely popular as a recreational drug in some areas, and carries a high potential for addiction. Reported as being a little more 'stimulating' than other opioids.", "effectsSummary": "Oxycodone has analgesic, depressant, antianxiety, cough suppressant and psychotropic properties. More intense dreams may also occur. Due to its relaxing and euphoric properties, it is used as a recreational drug, and is said to be more stimulating and mood-lifting than other opioids.", "generalRisks": "Very common side effects, as with all opioids, are constipation and constriction of the pupils. Drowsiness, dizziness, headache, itching, muscle twitching, sleep disturbances and mood swings are also to be expected. In women, menstruation may also be absent.\nOther opioid-typical side effects such as hallucinations, confusion, vomiting and nausea are less common with oxycodone.\nOverdoses with oxycodone are life-threatening, as the substance has a strong respiratory depressant effect even in low doses when abused, which can lead to respiratory arrest and coma. For opioid addicts, the lethal dose can be much higher. An overdose is treated by taking naloxone, an opioid antagonist.", "longtermRisks": "The consumption of oxycodone leads to physical and psychological dependence after a short time, even more quickly than with morphine. Tolerance builds up, which is why higher and higher doses have to be consumed. Strong withdrawal symptoms such as restlessness, irritability, depression, insomnia, sweating, cold shivers, vomiting, diarrhoea and painful cramps may occur.", "saferUse": [ "Opioids are highly effective drugs that should only be used for a limited time and at best under medical supervision.", "Start with a low dose and wait for the effect and tolerance before adding more. Do not exceed the maximum daily dose.", "If you inject opioids, dose even more carefully, as the range between desired effect (rush) and dangerous overdose is even more difficult to assess. Avoid injecting fentanyl; the risk of overdose is particularly high. Always use new (clean and sterile) injection material! Never exchange syringes, filters, water, disinfection swabs to avoid transmission of hepatitis and HIV.", "Do not rely on dosage information from colleagues who regularly use opioids. Due to habituation or dependence, their doses are much higher and can be fatal for new users.", "Take longer breaks (at least several days) between consumption.", "After a period of abstinence, take a much lower dose! The usual dose before the abstinence phase can otherwise quickly have life-threatening consequences.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, benzodiazepines and/or other opioids is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!", "Refrain from citrus fruits (especially grapefruit) before or during consumption. The combination can lead to an increase in the effect of the opiate and/or to respiratory depression." ], "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 7.5, "strongMin": 15, "heavyMin": 25 }, "duration": { "onset": { "min": 2, "max": 5, "units": "minutes" }, "total": { "min": 3, "max": 5, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 10, "strongMin": 25, "heavyMin": 40 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "total": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "Oxymorphone", "commonNames": [ "Opana" ], "url": "https://psychonautwiki.org/wiki/Oxymorphone", "isApproved": true, "crossTolerances": [ "opioids" ], "toxicities": [], "categories": [ "opioid", "habit-forming", "depressant" ], "summary": "A powerful semisynthetic opioid analgesic also known as opana. A derivative of morphine it is approximately ten times as potent. Has a low oral bioavailability, and as such it is usually insufflated or taken rectally.", "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2.5, "commonMin": 10, "strongMin": 20, "heavyMin": 30 }, "duration": { "onset": { "min": 20, "max": 45, "units": "minutes" }, "total": { "min": 4, "max": 6, "units": "hours" } } } ] }, { "name": "PARGY-LAD", "commonNames": [ "PARGY-LAD" ], "url": "https://psychonautwiki.org/wiki/PARGY-LAD", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic" ], "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 50, "commonMin": 275, "strongMin": 500, "heavyMin": 700 }, "duration": { "onset": { "min": 30, "max": 45, "units": "minutes" }, "total": { "min": 6, "max": 8, "units": "hours" } } } ] }, { "name": "PCE", "commonNames": [ "PCE", "Eticyclidine" ], "url": "https://psychonautwiki.org/wiki/PCE", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative" ], "addictionPotential": "highly addictive with a high potential for adverse side effects such as psychosis", "toxicities": [], "categories": [ "dissociative", "tentative", "habit-forming" ], "summary": "Eticyclidine (PCE) is a Dissociative anesthetic that has hallucinogenic effects. Slightly more potent than Phencyclidine.", "interactions": { "dangerous": [ "Stimulants", "Depressant" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 4, "strongMin": 8, "heavyMin": 15 }, "duration": { "onset": { "min": 3, "max": 30, "units": "minutes" }, "comeup": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 15 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "comeup": { "min": 40, "max": 120, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 4, "strongMin": 8, "heavyMin": 12 }, "duration": { "onset": { "min": 2, "max": 20, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } } ] }, { "name": "PCP", "commonNames": [ "PCP", "Angel Dust", "Sherman", "Sernyl", "Wet", "Dust", "Supergrass", "Boat", "Tic Tac", "Zoom" ], "url": "https://psychonautwiki.org/wiki/PCP", "isApproved": true, "tolerance": { "full": "with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative|dissociatives" ], "addictionPotential": "highly addictive with a high potential for adverse side effects such as psychosis", "toxicities": [], "categories": [ "dissociative", "habit-forming" ], "summary": "A strong dissociative drug. PCP works primarily as an NMDA receptor antagonist. Also referred to as \"wet\" or \"angel dust\". Best known for stories of the strange and sometimes violent behaviour of those under its influence, though it is likely these are only in overdose cases.", "interactions": { "dangerous": [ "2C-T-x", "ΑMT", "5-MeO-xxT", "Dextromethorphan", "GHB", "GBL", "Tramadol", "MAOI" ], "unsafe": [ "DOx", "Substituted amphetamines", "MDMA", "Cocaine", "Alcohol", "Benzodiazepines", "SSRIs" ], "uncertain": [ "Methoxetamine", "Caffeine", "Opioids" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 4, "strongMin": 8, "heavyMin": 15 }, "duration": { "onset": { "min": 3, "max": 30, "units": "minutes" }, "comeup": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 15 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "comeup": { "min": 40, "max": 120, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 4, "strongMin": 8, "heavyMin": 12 }, "duration": { "onset": { "min": 2, "max": 20, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } } ] }, { "name": "Pentedrone", "commonNames": [ "Pentedrone", "Drone" ], "url": "https://psychonautwiki.org/wiki/Pentedrone", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "stimulant", "research-chemical", "habit-forming" ], "summary": "A potent NDRI cathinone-type stimulant with more-ish effects but not thought to be especially enjoyable.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 10, "heavyMin": 20 }, "duration": { "onset": { "min": 5, "max": 10, "units": "minutes" }, "peak": { "min": 30, "max": 90, "units": "minutes" }, "offset": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 1, "max": 4, "units": "hours" }, "afterglow": { "min": 1, "max": 8, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 10, "strongMin": 15, "heavyMin": 25 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 2, "max": 6, "units": "hours" }, "afterglow": { "min": 1, "max": 10, "units": "hours" } } } ] }, { "name": "Pentobarbital", "commonNames": [ "Pentobarbital", "pentobarbitone", "Nembutal" ], "url": "https://psychonautwiki.org/wiki/Pentobarbital", "isApproved": true, "crossTolerances": [], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "moderate toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "habit-forming", "barbiturate" ], "summary": "A CNS depressant drug that is of the barbituate class. Typically not used often as it is easier to OD on than benzodiazepines, the new alternative to barbituates. Used often for insomnia, to cause sedation.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 100, "strongMin": 200, "heavyMin": 300 }, "duration": { "onset": { "min": 15, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 1, "max": 36, "units": "hours" } } } ] }, { "name": "Pethidine", "commonNames": [ "Pethidine", "Meperidine", "Demerol", "Dolantin", "Dolcontral" ], "url": "https://psychonautwiki.org/wiki/Pethidine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "extremely addictive with a high potential for abuse", "toxicities": [ "high toxicity", "potentially lethal when mixed with depressants like alcohol or benzodiazepines" ], "categories": [ "opioid", "habit-forming", "depressant" ], "summary": "A phenylpiperidine opioid first synthesised by Otto Eisleb in 1939, better known by the names meperidine and pethidine. An analgesic, once widely prescribed it has since declined in usage due to the discovery of a toxic metabolite - norpethidine. Also reacts dangerously with many drugs.", "interactions": { "dangerous": [ "SNRIs", "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 100, "strongMin": 200, "heavyMin": 400 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 10, "units": "hours" } } } ] }, { "name": "Phenazepam", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Phenazepam", "isApproved": false, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7-14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "research-chemical", "habit-forming" ], "summary": "A very long acting, potent and subtle benzodiazepine. Infamous for the calamitous experiences it tends to produce in people dosing unknown amounts. Prescribed in certain countries for epilepsy and alcohol withdrawal.", "interactions": { "dangerous": [ "Depressant", "Dissociatives" ], "unsafe": [], "uncertain": [ "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 2, "strongMin": 4, "heavyMin": 5 }, "duration": { "onset": { "min": 1, "max": 4, "units": "hours" }, "total": { "min": 15, "max": 24, "units": "hours" }, "afterglow": { "min": 15, "max": 36, "units": "hours" } } } ] }, { "name": "Phenibut", "commonNames": [ "Phenibut", "Fenibut", "Phenybut", "PhGABA" ], "url": "https://psychonautwiki.org/wiki/Phenibut", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "GABA" ], "addictionPotential": "moderately physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol, benzodiazepines or opioids" ], "categories": [ "depressant", "research-chemical", "habit-forming", "nootropic" ], "summary": "A derivative of GABA with the addition of a phenyl ring which allows it to cross the Blood Brain Barrier. Is mostly used as an anti-anxiety and anti-insomnia medication. Tolerance and physical dependency builds very quickly.", "roas": [ { "name": "oral", "dose": { "units": "g", "lightMin": 0.25, "commonMin": 1, "strongMin": 2, "heavyMin": 3.5 }, "duration": { "onset": { "min": 1.5, "max": 3, "units": "hours" }, "comeup": { "min": 1.5, "max": 3, "units": "hours" }, "peak": { "min": 3, "max": 4, "units": "hours" }, "offset": { "min": 4, "max": 6, "units": "hours" }, "total": { "min": 10, "max": 16, "units": "hours" }, "afterglow": { "min": 6, "max": 24, "units": "hours" } } } ] }, { "name": "Phenobarbital", "commonNames": [ "Phenobarbital", "Phenobarbitone", "Luminal", "Phenobarb" ], "url": "https://psychonautwiki.org/wiki/Phenobarbital", "isApproved": true, "crossTolerances": [], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "moderate toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "habit-forming", "barbiturate" ], "summary": "CNS depressant that is used mostly for insomnia (In older patients) and epliepsy (in younger patients) And it a very strong narcotic, that can be taken most ways. It's used less as \"safer\" alternatives have been made (Benzodiazepines).", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 100, "strongMin": 150, "heavyMin": 300 }, "duration": { "onset": { "min": 15, "max": 60, "units": "minutes" }, "peak": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 1, "max": 48, "units": "hours" } } } ] }, { "name": "Phenylpiracetam", "commonNames": [ "Phenylpiracetam", "Phenotropil", "Carphedon" ], "url": "https://psychonautwiki.org/wiki/Phenylpiracetam", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "racetam", "nootropic" ], "addictionPotential": "non-addictive with a low potential for abuse", "toxicities": [ "safe even when high doses are consumed for a long period of time", "exact toxic dosage is unknown" ], "categories": [ "stimulant", "nootropic", "research-chemical" ], "summary": "A nootropic and piracetam analogue also known as fonturacetam, this drug has been shown to have potential memory enhancing, anxiolytic, anti-amnesia and anti-depressive effects, however has little recreational value. Around 45x more potent than Piracetam.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 100, "strongMin": 200, "heavyMin": 400 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 2, "max": 3, "units": "hours" } } } ] }, { "name": "Piracetam", "commonNames": [ "Piracetam" ], "url": "https://psychonautwiki.org/wiki/Piracetam", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "racetam", "nootropic" ], "addictionPotential": "not addictive with a low potential for abuse", "toxicities": [], "categories": [ "nootropic" ], "summary": "A racetam nootropic claimed by many to have cognitive benefits however this has never been strongly supported in healthy individuals. Prescribed in the UK as a treatment for myoclonus. Potentially an ampakine. One of the first popular 'nootropics.'", "roas": [ { "name": "oral", "dose": { "units": "g", "lightMin": 0.25, "commonMin": 2, "strongMin": 3, "heavyMin": 5 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 4, "max": 8, "units": "hours" } } } ] }, { "name": "PMA", "commonNames": [ "PMA" ], "url": "https://psychonautwiki.org/wiki/PMA", "isApproved": true, "crossTolerances": [], "toxicities": [ "can be considered extremely toxic when compared to other substances such as Methamphetamine or MDMA", "Ingestion of PMA has been associated with severe tachycardia (abnormally high heart rate), seizures, hyperthermia, and death" ], "categories": [ "entactogen", "hallucinogen", "stimulant", "tentative" ], "summary": "An empathogen with a slow onset and very strong serotonin release. This, combined with its lack of dopamine release, often leads users to dose more for the pleasurable effects which never come, leading to hospitalisations and deaths. Sometimes mis-sold as MDMA.", "interactions": { "dangerous": [ "Tramadol", "ΑMT", "MAOI" ], "unsafe": [ "Dextromethorphan", "PCP", "25x-NBOMe", "2C-T-x", "5-MeO-xxT", "DOx" ], "uncertain": [ "Alcohol", "GHB", "GBL", "Opioids", "Cocaine", "Cannabis", "Caffeine", "Ketamine", "Methoxetamine", "Psychedelics" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 40, "strongMin": 60 } } ] }, { "name": "PMMA", "commonNames": [ "PMMA" ], "url": "https://psychonautwiki.org/wiki/PMMA", "isApproved": true, "crossTolerances": [], "toxicities": [ "can be considered extremely toxic when compared to other substances such as Methamphetamine or MDMA", "Ingestion of PMMA has been associated with severe tachycardia (abnormally high heart rate), seizures, hyperthermia, and death" ], "categories": [ "entactogen" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "commonMin": 100, "strongMin": 120 } } ] }, { "name": "Poppers", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Poppers", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [], "effectsSummary": "Muscle relaxation, drop in blood pressure, increase in heart rate, feeling of warmth or heat, short-term insensitivity to pain, euphoria and intensification of orgasm.", "generalRisks": "Headache, dizziness, palpitations, loss of consciousness, fainting and circulatory collapse due to severe drop in blood pressure.", "longtermRisks": "With regular use, permanent impairment of attention and memory as well as reduction of reaction time, cardiac arrhythmia as well as liver and kidney dysfunction, nerve and brain damage.", "saferUse": [ "Do not consume poppers alone.", "Do not add more right away (danger of circulatory collapse!).", "Refrain from mixed consumption of any kind, especially with alcohol.", "Follow the safer sex rules. Do not combine poppers with Viagra (risk of heart failure. Danger to life!).", "People with respiratory and cardiovascular diseases, epileptics and pregnant women should not consume poppers.", "Do not swallow! Drinking poppers can lead to a severe overdose, which can result in a fatal oxygen deficiency (methaemoglobinaemia) - contact poison control!", "Poppers are irritating on contact with eyes and mucous membranes. Rinse immediately with plenty of water and seek medical attention!", "Caution: Eye damage! Avoid poppers with the active ingredient (iso)propyl nitrite, it is suspected of causing partly irreversible visual disturbances. The active ingredient amyl nitrite does not seem to cause such damage. Some online shops now list the composition." ], "roas": [] }, { "name": "Pramiracetam", "commonNames": [ "Pramiracetam" ], "url": "https://psychonautwiki.org/wiki/Pramiracetam", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "racetam", "nootropic" ], "addictionPotential": "not addictive with a low potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "nootropic" ], "summary": "A CNS stimulant that is a nootropic, that belongs to the racetam family of compounds. Much more potent than Piracetam while appearing to work on similar mechanisms.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 100, "commonMin": 500, "strongMin": 800, "heavyMin": 1200 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "total": { "min": 4, "max": 7, "units": "hours" } } } ] }, { "name": "Pregabalin", "commonNames": [ "Pregabalin", "Lyrica", "Nervalin" ], "url": "https://psychonautwiki.org/wiki/Pregabalin", "isApproved": true, "tolerance": { "full": "within several months of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [], "toxicities": [ "low toxicity" ], "categories": [ "depressant", "habit-forming", "common" ], "summary": "Pregabalin (Lyrica) is a GABA derivative that is used to treat neuropathic pain and seizures, as well as anxiety.", "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "Oxycodone", "SSRIs", "MDMA" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 225, "strongMin": 600, "heavyMin": 900 }, "duration": { "onset": { "min": 30, "max": 45, "units": "minutes" }, "comeup": { "min": 1, "max": 2, "units": "hours" }, "peak": { "min": 4, "max": 6, "units": "hours" }, "offset": { "min": 4, "max": 8, "units": "hours" }, "total": { "min": 9, "max": 17, "units": "hours" }, "afterglow": { "min": 4, "max": 10, "units": "hours" } }, "bioavailability": { "max": 90 } }, { "name": "rectal", "dose": { "units": "mg", "lightMin": 40, "commonMin": 200, "strongMin": 450, "heavyMin": 600 }, "duration": { "onset": { "min": 15, "max": 30, "units": "minutes" }, "comeup": { "min": 30, "max": 120, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 3, "max": 5, "units": "hours" }, "total": { "min": 5, "max": 8, "units": "hours" }, "afterglow": { "min": 6, "max": 12, "units": "hours" } } } ] }, { "name": "PRO-LAD", "commonNames": [ "PRO-LAD" ], "url": "https://psychonautwiki.org/wiki/PRO-LAD", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "5-7 days", "zero": "14 days", "halfToleranceInHours": 144, "zeroToleranceInHours": 336 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "tentative" ], "summary": "A very rare lysergamide that is slightly less potent than LSD, yet with a shorter duration of action.", "interactions": { "dangerous": [ "Lithium" ], "unsafe": [ "Tramadol" ], "uncertain": [ "Cannabis", "Stimulants" ] }, "roas": [ { "name": "oral", "dose": { "units": "µg", "lightMin": 20, "commonMin": 100, "strongMin": 200, "heavyMin": 350 }, "duration": { "onset": { "min": 30, "max": 45, "units": "minutes" }, "total": { "min": 6, "max": 8, "units": "hours" } } } ] }, { "name": "Prochlorperazine", "commonNames": [ "Compazine", "Stemzine", "Buccastem", "Stemetil", "Phenotil" ], "url": "https://psychonautwiki.org/wiki/Prochlorperazine", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "antipsychotic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 5, "strongMin": 20, "heavyMin": 40 }, "duration": { "onset": { "min": 30, "max": 45, "units": "minutes" }, "total": { "min": 4, "max": 8, "units": "hours" } } } ] }, { "name": "Prolintane", "commonNames": [ "Prolintane" ], "url": "https://psychonautwiki.org/wiki/Prolintane", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "stimulant", "research-chemical", "tentative", "habit-forming" ], "summary": "A stimulant drug which is a dopamine reuptake inhibitor, related to MDPV and Pyrovalerone. It was first developed in the 1950s, and has seen some light usage in rave culture, though it remains relatively uncommon. Believed to have a relatively forgiving safety profile.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 25, "strongMin": 45, "heavyMin": 60 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 2, "max": 6, "units": "hours" } } } ] }, { "name": "Promethazine", "commonNames": [ "Phenergan", "Lergigan" ], "url": "https://psychonautwiki.org/wiki/Promethazine", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "deliriant", "depressant", "common" ], "summary": "A first generation antihistamine, which also possesses anticholinergic, strong sedative and antipsychotic properties. Once commonly used as a treatment for psychosis, it is now more commonly seen as a component of codeine cough syrups as an anti-nausea agent.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 25, "strongMin": 50, "heavyMin": 100 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "comeup": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 3, "max": 5, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "max": 12, "units": "hours" } } } ] }, { "name": "Propylhexedrine", "commonNames": [ "Propylhexedrine", "Benzedrex" ], "url": "https://psychonautwiki.org/wiki/Propylhexedrine", "isApproved": true, "tolerance": { "full": "rapidly develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dopamine", "stimulant" ], "toxicities": [], "categories": [ "stimulant", "habit-forming", "common" ], "summary": "A relatively common CNS stimulant sold over the counter in benzedrex inhalers.", "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 62.5, "strongMin": 125, "heavyMin": 187.5 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "comeup": { "min": 15, "max": 90, "units": "minutes" }, "peak": { "min": 2, "max": 5, "units": "hours" }, "offset": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 4, "max": 10, "units": "hours" }, "afterglow": { "min": 2, "max": 12, "units": "hours" } } } ] }, { "name": "Proscaline", "commonNames": [ "Proscaline" ], "url": "https://psychonautwiki.org/wiki/Proscaline", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "no negative health effects attributed to trying this drug" ], "categories": [ "psychedelic", "research-chemical" ], "summary": "A very uncommon psychedelic stimulant and phenethylamine and analogue on mescaline with similar effects. Roughly 5-7 times more potent than mescaline by weight.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 30, "strongMin": 40, "heavyMin": 60 }, "duration": { "total": { "min": 8, "max": 12, "units": "hours" } } } ] }, { "name": "Psilocin", "commonNames": [ "Psilocin", "Psilocine", "Psilocyn", "Psilotsin", "4-HO-DMT", "4-OH-DMT" ], "url": "https://psychonautwiki.org/wiki/Psilocin", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "extremely low toxicity" ], "categories": [ "psychedelic", "tentative", "entactogen", "research-chemical" ], "summary": "Psilocin is a substutued tryptamine alkaloid, that is present in most psychedelic mushrooms. It is relatively unstable in solution due to the -OH group.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 15, "strongMin": 25, "heavyMin": 40 }, "duration": { "onset": { "min": 20, "max": 45, "units": "minutes" }, "comeup": { "min": 1.5, "max": 3, "units": "hours" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1.5, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 24, "units": "hours" } } } ] }, { "name": "Psilocybe cubensis", "commonNames": [ "Shrooms", "Magic mushroom" ], "url": "https://psychonautwiki.org/wiki/Psilocybe_cubensis", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [], "roas": [] }, { "name": "Psilocybin mushrooms", "commonNames": [ "Psilocybin", "Psilocybin mushrooms", "Magic Mushrooms", "Shrooms", "4-PO-DMT" ], "url": "https://psychonautwiki.org/wiki/Psilocybin_mushrooms", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "toxicities": [ "extremely low toxicity relative to dose" ], "categories": [ "psychedelic" ], "effectsSummary": "Low doses have a stimulating and strengthening effect. Medium doses have a mild hallucinogenic effect and stimulate the imagination. High doses have a strong hallucinogenic effect, very psychedelic; the environment is often perceived as dreamlike; visionary immersion in strange worlds, deep insights into oneself and a feeling of strong connection with nature.", "dosageRemark": "Average dosages of dried* mushrooms:\nPointed cone bald: light 0.5-0.8 g, medium to strong 1.0-max. 2 g\nHawaiian: light 0.3-0.5 g, medium to strong 0.5-max. 1 g\nMexican: light 0.5-1.5 g, medium to strong 1.5-max. 5 g\n*for fresh mushrooms approx. ten times this amount.\nx mg psilocybin is stored in each fully developed fruit body. So the number of species is more relevant than the quantity.", "generalRisks": "The pupils dilate, pulse and blood pressure change, increase in body temperature (sweating), breathing difficulties and palpitations may occur. Occasionally, nausea may occur. Balance disorders, an altered sense of space-time, confusion and anxiety are also possible; panic attacks may occur in the case of stimulus overload.\nThe use of psilocybin can trigger latent (hidden) mental disorders.\nWhen picking mushrooms in nature, there is a risk of confusion due to deadly doppelgangers!", "saferUse": [ "Consume mushrooms only in good mental and physical condition (set).", "Do not consume mushrooms alone, but with someone you trust.", "Pay attention to the setting. A stress-free environment is important, preferably in nature. Mushrooms are not party drugs!", "Consume mushrooms only after a light meal; it is best to eat very little for 6 to 8 hours to avoid nausea and other unpleasant side effects. Chew mushrooms well!", "Use dried mushrooms if possible; wash raw mushrooms well before eating.", "In delicate moments during the trip: let yourself go, try not to fight the effect of the mushrooms.", "Avoid mixed consumption, never consume mushrooms together with alcohol or medication!", "Avoid roads and other \"dangerous\" places, your orientation may be disturbed.", "In case of panic attacks or horror trips: see General Information under Emergency.", "After the trip, allow yourself plenty of rest and recovery, at least the day after, to be able to process the experience." ], "interactions": { "dangerous": [], "unsafe": [ "Tramadol", "Lithium" ], "uncertain": [ "Cannabis", "Substituted amphetamines", "Cocaine" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2.5, "commonMin": 10, "strongMin": 25, "heavyMin": 50 }, "duration": { "onset": { "min": 20, "max": 45, "units": "minutes" }, "comeup": { "min": 1, "max": 1.5, "units": "hours" }, "peak": { "min": 2, "max": 2.5, "units": "hours" }, "offset": { "min": 2.5, "max": 3.5, "units": "hours" }, "total": { "min": 6, "max": 8, "units": "hours" }, "afterglow": { "min": 4, "max": 24, "units": "hours" } } } ] }, { "name": "Pyrazolam", "commonNames": [ "Pyrazolam" ], "url": "https://psychonautwiki.org/wiki/Pyrazolam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "research-chemical", "habit-forming" ], "summary": "RC benzodiazepine discovered by Hoffman-LaRoche in the 1970s. Came to the RC market in the early 2010s. At lower doses it is mainly an anxiolytic compound, yet at higher doses can be quite sedating, hypnotic, amnesic, and can cause loss of inhibitions. Structurally similar to Alprazolam, Bromazepam, and Triazolam. Is 12x as potent as Diazepam.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 2, "strongMin": 3, "heavyMin": 4 }, "duration": { "onset": { "min": 10, "max": 15, "units": "minutes" }, "total": { "min": 5, "max": 8, "units": "hours" } } } ] }, { "name": "Quetiapine", "commonNames": [ "Quetiapine", "Seroquel" ], "url": "https://psychonautwiki.org/wiki/Quetiapine", "isApproved": true, "tolerance": { "full": "within a week of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [], "addictionPotential": "moderately physically and psychologically addictive", "toxicities": [ "low toxicity" ], "categories": [ "antipsychotic", "depressant" ], "summary": "An atypical antipsychotic medication under the brand name Seroquel. Also used to treat insomnia and mood swings. This drug is very sedating and can stop/slow down psychedelic drug trips. Infrequently abused.", "interactions": { "dangerous": [ "Depressant" ], "unsafe": [], "uncertain": [ "Stimulants", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 10, "commonMin": 50, "strongMin": 150, "heavyMin": 300 }, "duration": { "onset": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1.5, "max": 6, "units": "hours" }, "offset": { "min": 6, "max": 7, "units": "hours" }, "total": { "min": 4, "max": 8, "units": "hours" }, "afterglow": { "min": 24, "max": 48, "units": "hours" } }, "bioavailability": { "min": 100, "max": 100 } } ] }, { "name": "Risperidone", "commonNames": [ "Risperdal" ], "url": "https://psychonautwiki.org/wiki/Risperidone", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "antipsychotic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.25, "commonMin": 1, "strongMin": 3, "heavyMin": 6 }, "duration": { "onset": { "min": 20, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 8, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 12, "max": 20, "units": "hours" } } } ] }, { "name": "Rolicyclidine", "commonNames": [ "PCPy" ], "url": "https://psychonautwiki.org/wiki/Rolicyclidine", "isApproved": false, "tolerance": { "full": "with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "dissociative|dissociatives" ], "addictionPotential": "highly addictive with a high potential for adverse side effects such as psychosis", "toxicities": [], "categories": [ "dissociative", "research-chemical", "habit-forming", "tentative" ], "summary": "Rolicyclidine, also known as PCPy, is a dissociative with effects similar to PCP. While this dissociative anesthetic has hallucinogenic and sedative effects, it is said to be much less stimulating than PCP. In this sense it is more similar to opioids, or other central nervous system depressants.", "interactions": { "dangerous": [ "2C-T-x", "ΑMT", "5-MeO-xxT", "GHB", "GBL", "Tramadol", "MAOI", "Opioids" ], "unsafe": [ "DOx", "Substituted amphetamines", "MDMA", "Cocaine", "Alcohol", "Benzodiazepines", "SSRIs", "Dextromethorphan" ], "uncertain": [ "Methoxetamine", "Caffeine" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 4, "strongMin": 8, "heavyMin": 15 }, "duration": { "onset": { "min": 3, "max": 30, "units": "minutes" }, "comeup": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 1, "commonMin": 5, "strongMin": 9, "heavyMin": 13 }, "duration": { "onset": { "min": 20, "max": 90, "units": "minutes" }, "comeup": { "min": 30, "max": 120, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 3, "max": 4, "units": "hours" }, "total": { "min": 6, "max": 12, "units": "hours" }, "afterglow": { "min": 12, "max": 48, "units": "hours" } } }, { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 4, "strongMin": 8, "heavyMin": 12 }, "duration": { "onset": { "min": 2, "max": 20, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 2, "max": 3, "units": "hours" }, "offset": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 4, "max": 48, "units": "hours" } } } ] }, { "name": "Salvinorin A", "commonNames": [ "Salvia", "Salvia divinorum", "Diviner's Sage", "Ska María Pastora", "Seer's Sage", "Sally" ], "url": "https://psychonautwiki.org/wiki/Salvinorin_A", "isApproved": true, "crossTolerances": [ "hallucinogen" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "hallucinogen", "dissociative", "deliriant", "depressant", "common" ], "summary": "A plant which, when smoked, causes short but very intense psychedelic experiences. It is considered physically safe, though users of high dosages often experience bizarre other-worldly scenarios which may be confusing or terrifying.", "roas": [ { "name": "smoked", "duration": { "onset": { "min": 15, "max": 60, "units": "seconds" }, "total": { "min": 15, "max": 90, "units": "minutes" }, "afterglow": { "min": 15, "max": 60, "units": "minutes" } } }, { "name": "sublingual", "duration": { "onset": { "min": 10, "max": 20, "units": "minutes" }, "total": { "min": 30, "max": 90, "units": "minutes" }, "afterglow": { "min": 30, "max": 120, "units": "minutes" } } } ] }, { "name": "Salvinorin B methoxymethyl ether", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Salvinorin_B_methoxymethyl_ether", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "hallucinogen" ], "roas": [] }, { "name": "SAM-e", "commonNames": [ "S-Adenosyl Methionine", "SAM-e", "Methylguanidoacetic Acid" ], "url": "https://psychonautwiki.org/wiki/SAM-e", "isApproved": true, "crossTolerances": [], "addictionPotential": "not habit-forming with a low potential for abuse", "toxicities": [], "categories": [ "nootropic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 200, "commonMin": 800, "strongMin": 1200, "heavyMin": 1600 }, "duration": { "onset": { "min": 100, "max": 180, "units": "minutes" } } } ] }, { "name": "Secobarbital", "commonNames": [ "Secobarbital", "Secobarbitone", "Seconal" ], "url": "https://psychonautwiki.org/wiki/Secobarbital", "isApproved": true, "crossTolerances": [], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "moderate toxicity" ], "categories": [ "depressant", "habit-forming", "barbiturate" ], "summary": "A Barbiturate derivative that possesses all the classic effects of todays Benzodiazepines, and the old Barbiturates. It's used in the treatment of Epilepsy, short term treatment for insomnia, and a preoperative medication for anaesthesia and anxiolysis for short surgical/diagnostic/therapeutic procedures.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 20, "commonMin": 50, "strongMin": 150, "heavyMin": 300 }, "duration": { "onset": { "min": 15, "max": 60, "units": "minutes" }, "peak": { "min": 4, "max": 8, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" }, "afterglow": { "min": 1, "max": 24, "units": "hours" } } } ] }, { "name": "STS-135", "commonNames": [ "STS-135" ], "url": "https://psychonautwiki.org/wiki/STS-135", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "cannabinoids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "cannabinoid" ], "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "2C-T-x", "2C-x", "5-MeO-xxT", "Substituted amphetamines", "ΑMT", "Cocaine", "DMT", "DOx", "LSD", "Mescaline", "Psilocybin mushrooms", "25x-NBOMe" ] }, "roas": [ { "name": "smoked", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 1.5, "strongMin": 2, "heavyMin": 4 }, "duration": { "onset": { "min": 10, "max": 45, "units": "seconds" }, "comeup": { "min": 10, "max": 45, "units": "minutes" }, "peak": { "min": 10, "max": 30, "units": "minutes" }, "offset": { "min": 5, "max": 10, "units": "minutes" }, "total": { "min": 30, "max": 60, "units": "minutes" }, "afterglow": { "min": 15, "max": 45, "units": "minutes" } } } ] }, { "name": "Sufentanil", "commonNames": [ "Sufentanil", "Sufentanyl", "Sufenta", "Chronogesic" ], "url": "https://psychonautwiki.org/wiki/Sufentanil", "isApproved": true, "crossTolerances": [], "toxicities": [], "categories": [ "opioid", "depressant", "habit-forming" ], "summary": "An synthetic analgesic drug that is roughly between 5-10x the potency of it's parent drug, (Fentanyl); It's use is very contained to surgery and post-operative pain.", "interactions": { "dangerous": [ "SNRIs", "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "intravenous", "dose": { "units": "µg", "lightMin": 0.1, "commonMin": 5, "strongMin": 10, "heavyMin": 25 }, "duration": { "onset": { "min": 1, "max": 2, "units": "minutes" }, "peak": { "min": 5, "max": 10, "units": "minutes" } } } ] }, { "name": "Tapentadol", "commonNames": [ "Tapentadol", "Nucynta", "Palexia", "Yantil", "Yantil SR" ], "url": "https://psychonautwiki.org/wiki/Tapentadol", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or benzodiazepines" ], "categories": [ "opioid", "habit-forming", "depressant" ], "summary": "An opioid analgesic drug with potency somewhere between tramadol and morphine, and with a similar action to Tramadol. Also an adrenergic reuptake inhibitor. High addiction potential. Potential for respiratory depression in overdose. Should not be combined with depressants or stimulants.", "interactions": { "dangerous": [ "SNRIs", "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 12.5, "commonMin": 50, "strongMin": 75, "heavyMin": 150 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "peak": { "min": 4, "max": 6, "units": "hours" }, "afterglow": { "min": 1, "max": 6, "units": "hours" } } } ] }, { "name": "Temazepam", "commonNames": [ "Temazepam", "Restoril", "Normison" ], "url": "https://psychonautwiki.org/wiki/Temazepam", "isApproved": true, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7-14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "habit-forming" ], "summary": "Temazepam's brand name is Restoril. It is a hypnotic benzodiazepine with effects similar to clonazepam, frequently prescribed as a sleep aid. Some users report mild euphoria alongside the hypnotic effects.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 10, "strongMin": 30, "heavyMin": 40 }, "duration": { "onset": { "min": 15, "max": 60, "units": "minutes" }, "total": { "min": 0.5, "max": 3, "units": "hours" }, "afterglow": { "min": 3.5, "max": 18.4, "units": "hours" } } } ] }, { "name": "Theacrine", "commonNames": [ "Theacrine", "Temurin", "Temorine" ], "url": "https://psychonautwiki.org/wiki/Theacrine", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [], "addictionPotential": "produces dependence with chronic use and has a low abuse potential", "toxicities": [], "categories": [ "stimulant", "nootropic" ], "summary": "Small alkaloid which can be seen as a structurally modified version of caffeine, with similar stimulating effects. It also shares anti-inflammatory and analgesic effects with caffeine.", "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 25, "commonMin": 25, "strongMin": 100 }, "duration": { "onset": { "min": 5, "max": 30, "units": "minutes" }, "total": { "min": 1, "max": 3, "units": "hours" } } }, { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 100, "strongMin": 150, "heavyMin": 300 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 6, "max": 10, "units": "hours" } } } ] }, { "name": "Theanine", "commonNames": [ "Theanine", "L-Theanine", "L-γ-glutamylethylamide and N5-ethyl-L-glutamine" ], "url": "https://psychonautwiki.org/wiki/Theanine", "isApproved": true, "tolerance": { "full": "after prolonged and repeated usage", "half": "5 days", "zero": "10 days", "halfToleranceInHours": 120, "zeroToleranceInHours": 240 }, "crossTolerances": [], "addictionPotential": "not habit-forming", "toxicities": [ "extremely low toxicity" ], "categories": [ "nootropic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 175, "strongMin": 300, "heavyMin": 500 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" } } } ] }, { "name": "Thebaine", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Thebaine", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [], "roas": [] }, { "name": "THJ-018", "commonNames": [ "THJ-018" ], "url": "https://psychonautwiki.org/wiki/THJ-018", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "cannabinoids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "cannabinoid" ], "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "2C-T-x", "2C-x", "5-MeO-xxT", "Substituted amphetamines", "ΑMT", "Cocaine", "DMT", "DOx", "LSD", "Mescaline", "Psilocybin mushrooms", "25x-NBOMe" ] }, "roas": [ { "name": "smoked", "dose": { "units": "mg", "lightMin": 1, "commonMin": 2, "strongMin": 3, "heavyMin": 5 }, "duration": { "onset": { "min": 5, "max": 10, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 5, "max": 10, "units": "minutes" }, "total": { "min": 2, "max": 3, "units": "hours" }, "afterglow": { "min": 60, "max": 90, "units": "minutes" } } } ] }, { "name": "THJ-2201", "commonNames": [ "THJ-2201" ], "url": "https://psychonautwiki.org/wiki/THJ-2201", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "cannabinoids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "exact toxic dosage is unknown" ], "categories": [ "cannabinoid" ], "interactions": { "dangerous": [], "unsafe": [], "uncertain": [ "2C-T-x", "2C-x", "5-MeO-xxT", "Substituted amphetamines", "ΑMT", "Cocaine", "DMT", "DOx", "LSD", "Mescaline", "Psilocybin mushrooms", "25x-NBOMe" ] }, "roas": [ { "name": "smoked", "dose": { "units": "mg", "lightMin": 0.5, "commonMin": 1, "strongMin": 2, "heavyMin": 5 }, "duration": { "onset": { "min": 5, "max": 10, "units": "minutes" }, "peak": { "min": 30, "max": 45, "units": "minutes" }, "offset": { "min": 0, "max": 0, "units": "minutes" }, "total": { "min": 1, "max": 2, "units": "hours" }, "afterglow": { "min": 60, "max": 90, "units": "minutes" } } } ] }, { "name": "Tianeptine", "commonNames": [ "Tianeptine", "Stablon", "Coaxil", "Tatinol" ], "url": "https://psychonautwiki.org/wiki/Tianeptine", "isApproved": true, "tolerance": { "full": "with prolonged use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "trycyclic antidepressants", "opioids" ], "addictionPotential": "mildly addictive", "toxicities": [ "large therapeutic index and margin of safety" ], "categories": [ "nootropic", "opioid", "antidepressant", "habit-forming", "depressant" ], "summary": "A Tricyclic antidepressant, that has quite unique pharmacological properties than others in its class. Such as the possible indirect action on NMDA/AMPA and a full agonist at the μ-opioid receptor. While abuse of this substance is uncommon, it has been shown in a few countries.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 3, "commonMin": 12, "strongMin": 35, "heavyMin": 100 }, "duration": { "onset": { "min": 30, "max": 60, "units": "minutes" }, "comeup": { "min": 15, "max": 30, "units": "minutes" }, "peak": { "min": 60, "max": 90, "units": "minutes" }, "offset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 2, "max": 3, "units": "hours" } } } ] }, { "name": "Tilidin", "commonNames": [ "Tilidine", "Tilidin", "Darby", "Valoron", "Generika" ], "url": "https://psychonautwiki.org/wiki/Tilidin", "isApproved": false, "crossTolerances": [], "toxicities": [], "categories": [], "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 50, "strongMin": 100, "heavyMin": 200 }, "duration": { "onset": { "min": 5, "max": 15, "units": "minutes" }, "comeup": { "min": 20, "max": 40, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 30, "max": 60, "units": "minutes" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 1, "max": 12, "units": "hours" } } } ] }, { "name": "TMA", "commonNames": [], "url": "https://psychonautwiki.org/wiki/TMA", "isApproved": false, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "stimulant" ], "roas": [ { "name": "oral", "dose": { "units": "70", "lightMin": 40, "commonMin": 140, "strongMin": 170, "heavyMin": 200 }, "duration": { "total": { "min": 6, "max": 12, "units": "hours" } } } ] }, { "name": "TMA-2", "commonNames": [ "TMA-2" ], "url": "https://psychonautwiki.org/wiki/TMA-2", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "stimulant", "research-chemical", "tentative" ], "summary": "Trimethoxyamphetamine-2, a psychedelic amphetamine and stimulant first synthesised by Alexander Shulgin. An uncommon compound of similar activity to other psychedelic amphetamines. Short history of human use.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 20, "max": 120, "units": "minutes" }, "comeup": { "min": 1.5, "max": 3, "units": "hours" }, "peak": { "min": 4, "max": 6, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 8, "max": 12, "units": "hours" }, "afterglow": { "min": 4, "max": 24, "units": "hours" } } } ] }, { "name": "TMA-6", "commonNames": [ "TMA-6" ], "url": "https://psychonautwiki.org/wiki/TMA-6", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "stimulant", "research-chemical", "tentative" ], "summary": "A rarely seen Psychedelic Amphetamine and Mescaline analogue. First synthesised by Alexander Shulgin, who descrived it as \"one of the most rewarding and pleasurable of the methoxylated amphetamines.\"", "interactions": { "dangerous": [ "SNRIs", "MAOI", "Serotonin releasers", "SSRIs", "5-Hydroxytryptophan" ], "unsafe": [], "uncertain": [] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 35, "heavyMin": 50 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "comeup": { "min": 1.5, "max": 3, "units": "hours" }, "peak": { "min": 5, "max": 8, "units": "hours" }, "offset": { "min": 3, "max": 5, "units": "hours" }, "total": { "min": 10, "max": 16, "units": "hours" }, "afterglow": { "min": 6, "max": 18, "units": "hours" } } } ] }, { "name": "Tramadol", "commonNames": [ "Tramadol", "Tramal", "Tadol", "Tramacur", "Tramundin" ], "url": "https://psychonautwiki.org/wiki/Tramadol", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or benzodiazepines" ], "categories": [ "opioid", "habit-forming", "depressant", "common" ], "summary": "A synthetic opioid analgesic, tramadol is used to treat moderate pain and can be considered a medium-strength opioid. Tramadol also has the unusual effect of being a serotonin releasing agent and a serotonin reuptake inhibitor, and as a consequence should not be taken in excess due to the risk of serotonin syndrome. Risk of seizures above 300mg doses.", "effectsSummary": "Analgesic, anxiety-relieving, euphoric, mood-lifting, causes a general feeling of contentment.\nThe human body has its own pain-relieving system. The endogenous substance endorphin ensures that pain messages are sent to the human brain in a reduced form by docking to certain receptors in the human body. The active ingredient tramadol has a similar mode of action in that the active ingredient attaches to neurotransmitter docking sites (opioid receptors) and transmits a signal to the brain, which subsequently triggers pain relief. In addition, tramadol inhibits the reuptake of certain nerve messengers (noradrenaline and serotonin), which in turn increases the amount of free messengers in the tissue and supports the analgesic effect.", "dosageRemark": "When consuming for the first time, low doses should be used, as the risk of respiratory arrest is increased.", "generalRisks": "Adverse side effects may include: headache, malaise/nausea, vomiting, dry mouth, dizziness, drowsiness, constipation, drowsiness, circulatory problems (palpitations, fainting spells, etc.).\nIn higher doses, seizures, speech disorders, paraesthesias (unpleasant bodily sensations, e.g. parts of the body falling asleep), tremor (muscle tremor), coordination disorders and circulatory collapse may occur. Hallucinations, confusion, delirium, anxiety, sleep disorders and nightmares can also be triggered.", "longtermRisks": "Tramadol has a low dependence potential with moderate use. However, regular and long-term use can lead to psychological and physical dependence. Immediate discontinuation of the drug after prolonged use can lead to negative withdrawal symptoms, which may manifest as dizziness, physical weakness, inner restlessness, tremors, sleep disturbances, headaches, sweating, nausea, hallucinations and depression.\nProlonged use can lead to general mood changes, changes in decision-making behaviour or perceptual and reaction disorders.", "saferUse": [ "Opioids are highly effective drugs that should only be used for a limited time and at best under medical supervision.", "Start with a low dose and wait for the effect and tolerance before adding more. Do not exceed the maximum daily dose.", "If you inject opioids, dose even more carefully, as the range between desired effect (rush) and dangerous overdose is even more difficult to assess. Avoid injecting fentanyl; the risk of overdose is particularly high. Always use new (clean and sterile) injection material! Never exchange syringes, filters, water, disinfection swabs to avoid transmission of hepatitis and HIV.", "Do not rely on dosage information from colleagues who regularly use opioids. Due to habituation or dependence, their doses are much higher and can be fatal for new users.", "Take longer breaks (at least several days) between consumption.", "After a period of abstinence, take a much lower dose! The usual dose before the abstinence phase can otherwise quickly have life-threatening consequences.", "The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, benzodiazepines and/or other opioids is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!", "Refrain from citrus fruits (especially grapefruit) before or during consumption. The combination can lead to an increase in the effect of the opiate and/or to respiratory depression." ], "interactions": { "dangerous": [ "Substituted amphetamines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "MAOI", "Grapefruit", "MDMA", "ΑMT" ], "unsafe": [ "2C-T-x" ], "uncertain": [ "Benzodiazepines", "Methoxetamine", "Alcohol", "Nitrous" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 25, "commonMin": 100, "strongMin": 250, "heavyMin": 300 }, "duration": { "onset": { "min": 15, "max": 60, "units": "minutes" }, "comeup": { "min": 30, "max": 60, "units": "minutes" }, "peak": { "min": 2, "max": 6, "units": "hours" }, "offset": { "min": 2, "max": 4, "units": "hours" }, "total": { "min": 6, "max": 10, "units": "hours" } }, "bioavailability": { "min": 70, "max": 90 } } ] }, { "name": "Triazolam", "commonNames": [], "url": "https://psychonautwiki.org/wiki/Triazolam", "isApproved": false, "tolerance": { "full": "within a couple of days of continuous use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "depressant", "benzodiazepine", "habit-forming" ], "summary": "An uncommon and very short acting benzodiazepine. Sedating and hypnotic, and may induce amnesia and lowered inhibitions at high doses.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 0.125, "commonMin": 0.25, "strongMin": 0.5, "heavyMin": 0.75 }, "duration": { "onset": { "min": 20, "max": 30, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "offset": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 3, "max": 6, "units": "hours" }, "afterglow": { "min": 1, "max": 12, "units": "hours" } } } ] }, { "name": "Tyrosine", "commonNames": [ "Tyrosine", "L-Tyrosine", "4-Hydroxyphenylalanine" ], "url": "https://psychonautwiki.org/wiki/Tyrosine", "isApproved": true, "tolerance": { "full": "after repeated and frequent usage", "half": "7 days", "zero": "14 days", "halfToleranceInHours": 168, "zeroToleranceInHours": 336 }, "crossTolerances": [ "dopamine" ], "addictionPotential": "mildly habit forming", "toxicities": [ "extremely low toxicity" ], "categories": [ "stimulant" ], "interactions": { "dangerous": [ "25x-NBOMe", "25x-NBOH", "Tramadol", "MAOI" ], "unsafe": [ "Dextromethorphan", "MDMA", "Stimulants" ], "uncertain": [ "Alcohol", "Methoxetamine", "Dissociatives" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 300, "commonMin": 1000, "strongMin": 2000, "heavyMin": 3000 }, "duration": { "onset": { "min": 30, "max": 90, "units": "minutes" }, "peak": { "min": 1, "max": 3, "units": "hours" }, "total": { "min": 2, "max": 4, "units": "hours" }, "afterglow": { "min": 6, "max": 12, "units": "hours" } } } ] }, { "name": "U-47700", "commonNames": [ "U-47700" ], "url": "https://psychonautwiki.org/wiki/U-47700", "isApproved": true, "tolerance": { "full": "develops with prolonged and repeated use", "half": "3 - 7 days", "zero": "1 - 2 weeks", "halfToleranceInHours": 120, "zeroToleranceInHours": 252 }, "crossTolerances": [ "opioids" ], "addictionPotential": "moderately addictive with a high potential for abuse", "toxicities": [ "high toxicity relative to its dose due to its extreme potency", "potentially lethal when mixed with depressants like alcohol or benzodiazepines" ], "categories": [ "opioid", "research-chemical", "habit-forming", "depressant" ], "summary": "A µ-opioid receptor agonist that is related to AH-7921. Having a very short duration.", "interactions": { "dangerous": [ "Alcohol", "Benzodiazepines", "Cocaine", "Dextromethorphan", "GHB", "GBL", "Ketamine", "Methoxetamine", "Tramadol", "Grapefruit" ], "unsafe": [], "uncertain": [ "Substituted amphetamines", "MAOI", "Nitrous", "PCP" ] }, "roas": [ { "name": "insufflated", "dose": { "units": "mg", "lightMin": 1, "commonMin": 6, "strongMin": 8, "heavyMin": 10 }, "duration": { "onset": { "min": 5, "max": 10, "units": "minutes" }, "comeup": { "min": 15, "max": 20, "units": "minutes" }, "peak": { "min": 1, "max": 2, "units": "hours" }, "total": { "min": 2, "max": 3, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "Zolpidem", "commonNames": [ "Ambien", "Intermezzo", "Edluar", "Zolpimist" ], "url": "https://psychonautwiki.org/wiki/Zolpidem", "isApproved": true, "crossTolerances": [], "addictionPotential": "moderately addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like alcohol or opioids" ], "categories": [ "hallucinogen", "depressant", "habit-forming", "common" ], "summary": "Commonly prescribed for insomnia, Ambien (zolpidem) can cause realistic hallucinations similar to those of deliriants, and is very likely to cause amnesia at higher doses. Take care when using this drug, as it tends to lower inhibitions to a level which causes the user to do things they might not normally do when sober.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 20, "strongMin": 30, "heavyMin": 50 }, "duration": { "onset": { "min": 15, "max": 45, "units": "minutes" }, "comeup": { "min": 30, "max": 45, "units": "minutes" }, "peak": { "min": 3, "max": 6, "units": "hours" }, "offset": { "min": 4, "max": 5, "units": "hours" }, "total": { "min": 5, "max": 10, "units": "hours" }, "afterglow": { "min": 2, "max": 4, "units": "hours" } } } ] }, { "name": "Zopiclone", "commonNames": [ "Zimovane", "Imovane" ], "url": "https://psychonautwiki.org/wiki/Zopiclone", "isApproved": true, "tolerance": { "full": "within a couple of weeks of daily use", "zero": "7 - 14 days", "zeroToleranceInHours": 252 }, "crossTolerances": [ "benzodiazepines" ], "addictionPotential": "extremely physically and psychologically addictive", "toxicities": [ "low toxicity", "potentially lethal when mixed with depressants like benzodiazepines, alcohol or opioids" ], "categories": [ "hallucinogen", "depressant", "habit-forming", "common" ], "summary": "A nonbenzodiazepine sedative sleep aid (Z-drug), which can have hallucinogenic effects if taken while awake. Often causes users to have a metallic taste in the mouth for ~12h. Has been reported in some cases to cause certain users to black out, redose excessively and undertake dangerous activities such as driving.", "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 2, "commonMin": 5, "strongMin": 7.5, "heavyMin": 15 }, "duration": { "onset": { "min": 10, "max": 30, "units": "minutes" }, "peak": { "min": 3, "max": 4, "units": "hours" }, "total": { "min": 3.5, "max": 9, "units": "hours" } } } ] }, { "name": "ΑMT", "commonNames": [ "AMT", "αMT", "Indopan" ], "url": "https://psychonautwiki.org/wiki/%CE%91MT", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "14 days", "zero": "1 month", "halfToleranceInHours": 336, "zeroToleranceInHours": 720 }, "crossTolerances": [ "psychedelics" ], "addictionPotential": "moderately habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic", "entactogen" ], "interactions": { "dangerous": [ "2C-T-x", "2C-x", "5-MeO-xxT", "Substituted amphetamines", "Cocaine", "DOx", "Dextromethorphan", "MAOI", "MDMA", "Mescaline", "Methoxetamine", "25x-NBOMe", "PCP", "SSRIs", "Tramadol" ], "unsafe": [], "uncertain": [ "Alcohol", "Caffeine", "Cannabis" ] }, "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 5, "commonMin": 25, "strongMin": 40, "heavyMin": 60 }, "duration": { "onset": { "min": 60, "max": 180, "units": "minutes" }, "peak": { "min": 4, "max": 6, "units": "hours" }, "total": { "min": 13, "max": 15, "units": "hours" }, "afterglow": { "min": 1, "max": 5, "units": "hours" } } } ] }, { "name": "Βk-2C-B", "commonNames": [ "βk-2C-B", "beta-keto 2C-B", "bk-2C-B" ], "url": "https://psychonautwiki.org/wiki/%CE%92k-2C-B", "isApproved": true, "tolerance": { "full": "almost immediately after ingestion", "half": "3 days", "zero": "7 days", "halfToleranceInHours": 72, "zeroToleranceInHours": 168 }, "crossTolerances": [ "psychedelic" ], "addictionPotential": "not habit-forming", "toxicities": [ "toxic dose is unknown" ], "categories": [ "psychedelic" ], "roas": [ { "name": "oral", "dose": { "units": "mg", "lightMin": 50, "commonMin": 80, "strongMin": 100, "heavyMin": 150 }, "duration": { "onset": { "min": 20, "max": 70, "units": "minutes" }, "total": { "min": 8, "max": 12, "units": "hours" } } } ] } ] }